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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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3,5-Dihydroxyphenyl-glycine: a potent agonist of metabotropic glutamate receptors.

An amino acid, 3,5-dihydroxyphenylglycine (DHPG) induced current responses in Xenopus oocytes expressing a metabotropic glutamate receptor clone mGluR1. Apparent EC50 of DHPG for mGluR1 was slightly lower than that of (+-)-1-aminocyclopentane-trans-1,3-dicarboxylic acid (ACPD). DHPG responses were partially inhibited by 2-amino-3-phosphonopropionic acid (AP-3). DHPG had no effect on ionotropic glutamate receptors whose expression was induced in the oocytes following injection of poly(A)+ mRNA of rat brains. In hippocampal slices, DHPG produced slow excitation of pyramidal cells, resulting from a depression of Ca(2+)-dependent K+ current and a voltage-dependent K+ current. These results indicate that DHPG is a specific and potent agonist of mGluRs.[1]

References

  1. 3,5-Dihydroxyphenyl-glycine: a potent agonist of metabotropic glutamate receptors. Ito, I., Kohda, A., Tanabe, S., Hirose, E., Hayashi, M., Mitsunaga, S., Sugiyama, H. Neuroreport (1992) [Pubmed]
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