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Chemical Compound Review

DHPG-3,5     2-amino-2-(3,5- dihydroxyphenyl)ethanoic acid

Synonyms: AG-E-43481, SureCN1512962, CHEBI:157903, AC1Q5RRL, AR-1H7011, ...
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Disease relevance of 3,5-Dhpg


High impact information on 3,5-Dhpg


Chemical compound and disease context of 3,5-Dhpg

  • (R,S)-alpha-Methyl-4-carboxyphenylglycine (200 mM/5 microliters), a metabotropic glutamate receptor antagonist, when applied prior to high-frequency tetanus and ADA or 3,5-dihydroxyphenylglycine, completely inhibited this effect [8].

Biological context of 3,5-Dhpg


Anatomical context of 3,5-Dhpg


Associations of 3,5-Dhpg with other chemical compounds


Gene context of 3,5-Dhpg

  • Bath application of the non-selective mGluR agonist (1 S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (1 S,3R-ACPD) or the group-I mGluR agonist 3,5-dihydroxyphenylglycine (DHPG) depolarized all cholinergic neurones tested by activation of an inward current at -60 mV [19].
  • Application of a selective group I agonist, 3,5-dihydroxyphenylglycine (DHPG), produced much greater induction of either mRNA (285 and 289% over control for PPD and PPE after 100 microM DHPG incubation, respectively) [20].
  • (S)-alpha-methyl-3-carboxyphenylalanine, which is a potent and selective antagonist for LAP4 in the cortex, is anticonvulsant in DBA/2 mice and decreases the convulsant effect of N-methyl-D-aspartate, 3,5-dihydroxyphenylglycine, LAP4 and MPPG in Swiss-Webster mice [21].

Analytical, diagnostic and therapeutic context of 3,5-Dhpg


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  19. Functional and molecular characterization of metabotropic glutamate receptors expressed in rat striatal cholinergic interneurones. Bell, M.I., Richardson, P.J., Lee, K. J. Neurochem. (2002) [Pubmed]
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