Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclins.
A human D-type cyclin gene ( CCND1/ cyclin D1/ PRAD1) was previously isolated by virtue of its ability to complement a triple G1 cyclin ( Cln) deficiency of Saccharomyces cerevisiae and was also identified as a candidate BCL1 oncogene. We now report the molecular cloning of two additional human D-type cyclin genes, CCND2 ( cyclin D2) and CCND3 ( cyclin D3). All three human D-type cyclin genes encode small (33-34 kDa) proteins that share an average of 57% identity over the entire coding region and 78% in the cyclin box. The D-type cyclins are most closely related to cyclin A (39% identity) and cyclin E (36%), followed by cyclin B (29%) and cyclin C (21%). Isolation and characterization of genomic clones revealed two pseudogenes corresponding to CCND2 and CCND3, respectively. All three cyclin D genes are interrupted by an intron at the same position. CCND2 has been mapped to chromosome 12p13, and CCND3 has been mapped to chromosome 6p21.[1]References
- Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclins. Xiong, Y., Menninger, J., Beach, D., Ward, D.C. Genomics (1992) [Pubmed]
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