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Gene Review

CCNY  -  cyclin Y

Homo sapiens

Synonyms: C10orf9, CBCP1, CCNX, CFP1, Cyc-Y, ...
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Disease relevance of CCNY


High impact information on CCNY

  • On cyclin A, it binds in a groove formed by conserved cyclin box residues [2].
  • The cyclin box fold: protein recognition in cell-cycle and transcription control [3].
  • The N-terminal cyclin box fold of cyclin E1 is similar to that of cyclin A and promotes identical changes in pCDK2 that lead to kinase activation [4].
  • The specificity of the cyclin H molecule is provided mainly by two long helices which extend the cyclin fold at its N- and C-termini and pack together against the first repeat on the side opposite to the kinase [5].
  • Although the cytoplasmic retention signal region is outside the cyclin box, its sequence is well conserved in human cyclin B2, and is both necessary and sufficient to keep cyclin B2 in the cytoplasm [6].

Biological context of CCNY

  • A novel cyclin gene was discovered by searching an expressed sequence tag database with a cyclin box profile [7].
  • The N-terminal 272 residues of hCyclinT1, including the entire cyclin domains and the Tat.TAR recognition motif (TRM), that fully support Tat transactivation was used for panning, and of the five unique anti-hCyclinT1 sFvs that were obtained, three bound to the cyclin box domains and two bound to TRM [8].
  • Our analysis demonstrates the existence of a number of islands of homology outside the cyclin box, and indicates candidate residues for phosphorylation [9].
  • The cyclin box and C-terminus of cyclins A and E specify CDK activation and substrate specificity [10].
  • Analysis of deletion mutants of glutathione-S-transferase (GST)-cyclin B2 mapped its binding domain for TGFbeta RII to the C-terminal and revealed a negative regulatory region immediately upstream of the cyclin box [11].

Anatomical context of CCNY


Other interactions of CCNY

  • Our findings also indicate that the cyclin box in cyclin E mediates the interaction with cdk2 [14].
  • A prominent feature of cyclin K is an additional helix (H4a) in the first cyclin box that obstructs the binding pocket for the cell-cycle inhibitor p27(Kip1) [15].
  • All three human D-type cyclin genes encode small (33-34 kDa) proteins that share an average of 57% identity over the entire coding region and 78% in the cyclin box [16].
  • Protein binding and REF assays showed that the region of the cyclin box required for the interaction with CDK4 as well as C-terminal sequences determining protein stability were crucial for transformation [17].
  • Moreover, the cyclin box of cyclin T1 and its immediate flanking region are largely responsible for the specific P-TEFb-Tat interaction [18].

Analytical, diagnostic and therapeutic context of CCNY


  1. Structural similarity between the pocket region of retinoblastoma tumour suppressor and the cyclin-box. Kim, H.Y., Cho, Y. Nat. Struct. Biol. (1997) [Pubmed]
  2. Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex. Russo, A.A., Jeffrey, P.D., Patten, A.K., Massagué, J., Pavletich, N.P. Nature (1996) [Pubmed]
  3. The cyclin box fold: protein recognition in cell-cycle and transcription control. Noble, M.E., Endicott, J.A., Brown, N.R., Johnson, L.N. Trends Biochem. Sci. (1997) [Pubmed]
  4. The structure of cyclin E1/CDK2: implications for CDK2 activation and CDK2-independent roles. Honda, R., Lowe, E.D., Dubinina, E., Skamnaki, V., Cook, A., Brown, N.R., Johnson, L.N. EMBO J. (2005) [Pubmed]
  5. The structure of cyclin H: common mode of kinase activation and specific features. Andersen, G., Busso, D., Poterszman, A., Hwang, J.R., Wurtz, J.M., Ripp, R., Thierry, J.C., Egly, J.M., Moras, D. EMBO J. (1997) [Pubmed]
  6. The differential localization of human cyclins A and B is due to a cytoplasmic retention signal in cyclin B. Pines, J., Hunter, T. EMBO J. (1994) [Pubmed]
  7. Cyclin E2, a novel G1 cyclin that binds Cdk2 and is aberrantly expressed in human cancers. Gudas, J.M., Payton, M., Thukral, S., Chen, E., Bass, M., Robinson, M.O., Coats, S. Mol. Cell. Biol. (1999) [Pubmed]
  8. Inhibition of Tat-mediated transactivation and HIV-1 replication by human anti-hCyclinT1 intrabodies. Bai, J., Sui, J., Zhu, R.Y., Tallarico, A.S., Gennari, F., Zhang, D., Marasco, W.A. J. Biol. Chem. (2003) [Pubmed]
  9. Conserved structural motifs in cyclins identified by sequence analysis. Nugent, J.H., Alfa, C.E., Young, T., Hyams, J.S. J. Cell. Sci. (1991) [Pubmed]
  10. The cyclin box and C-terminus of cyclins A and E specify CDK activation and substrate specificity. Horton, L.E., Templeton, D.J. Oncogene (1997) [Pubmed]
  11. Functional association of TGF-beta receptor II with cyclin B. Liu, J.H., Wei, S., Burnette, P.K., Gamero, A.M., Hutton, M., Djeu, J.Y. Oncogene (1999) [Pubmed]
  12. Molecular cloning and characterization of murine cyclin E. Damjanov, I., Shan, J., Wang, R.F., Damjanov, A., DeLoia, J.A. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
  13. Proteomic analysis of differentially expressed proteins between metastatic and non-metastatic human colorectal carcinoma cell lines. Ying-Tao, Z., Yi-Ping, G., Lu-Sheng, S., Yi-Li, W. European journal of gastroenterology & hepatology. (2005) [Pubmed]
  14. Alternative splicing of human cyclin E. Sewing, A., Rönicke, V., Bürger, C., Funk, M., Müller, R. J. Cell. Sci. (1994) [Pubmed]
  15. Crystal Structure of Human Cyclin K, a Positive Regulator of Cyclin-dependent Kinase 9. Baek, K., Brown, R.S., Birrane, G., Ladias, J.A. J. Mol. Biol. (2007) [Pubmed]
  16. Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclins. Xiong, Y., Menninger, J., Beach, D., Ward, D.C. Genomics (1992) [Pubmed]
  17. Functional domains in cyclin D1: pRb-kinase activity is not essential for transformation. Zwicker, J., Brüsselbach, S., Jooss, K.U., Sewing, A., Behn, M., Lucibello, F.C., Müller, R. Oncogene (1999) [Pubmed]
  18. Specific interaction of Tat with the human but not rodent P-TEFb complex mediates the species-specific Tat activation of HIV-1 transcription. Chen, D., Fong, Y., Zhou, Q. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  19. The expression of Brostm, a KNOTTED1-like gene, marks the cell type and timing of in vitro shoot induction in Brassica oleracea. Teo, W.L., Kumar, P., Goh, C.J., Swarup, S. Plant Mol. Biol. (2001) [Pubmed]
  20. A model of the complex between cyclin-dependent kinase 5 and the activation domain of neuronal Cdk5 activator. Chou, K.C., Watenpaugh, K.D., Heinrikson, R.L. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  21. Molecular cloning and antiserum development of cyclin box in the brown tide alga Aureococcus anophagefferens. Lin, S., Magaletti, E., Carpenter, E.J. Mar. Biotechnol. (2000) [Pubmed]
  22. Cyclins in a dinoflagellate cell cycle. Leveson, A., Wong, F., Wong, J.T. Mol. Marine Biol. Biotechnol. (1997) [Pubmed]
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