The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Quercetin arrests human leukemic T-cells in late G1 phase of the cell cycle.

The effect of quercetin, a flavonoid found in many plants, on the proliferation of human leukemic T-cells was analyzed. Quercetin reversibly blocked the cell cycle at a point 3-6 h before the start of DNA synthesis. Expression of the growth-related genes histone H4, cyclin A and B, and p34cdc2 was suppressed in cells blocked with quercetin. Comparison of the quercetin arrest points with those of the cell cycle inhibitors aphidicolin and mimosine revealed a temporal order of arrest points in G1 of quercetin, mimosine, and aphidicolin. Mimosine and aphidicolin did not inhibit the expression of cyclin A or p34cdc2, whereas all three reagents inhibited expression of cyclin B. Low concentrations of the protein inhibitor cycloheximide inhibited release of the quercetin but not the mimosine or aphidicolin block. A [35S]methionine-labeled M(r) 60,000 protein disappeared in quercetin-treated cells and was rapidly synthesized after removal of quercetin, suggesting the possibility that the M(r) 60,000 protein induces DNA synthesis after the cell is released from a quercetin block. These results suggest the usefulness of quercetin in studies of the regulation of late G1 phase.[1]


  1. Quercetin arrests human leukemic T-cells in late G1 phase of the cell cycle. Yoshida, M., Yamamoto, M., Nikaido, T. Cancer Res. (1992) [Pubmed]
WikiGenes - Universities