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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Coculture Techniques

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Disease relevance of Coculture Techniques


Psychiatry related information on Coculture Techniques


High impact information on Coculture Techniques


Chemical compound and disease context of Coculture Techniques


Biological context of Coculture Techniques


Anatomical context of Coculture Techniques


Associations of Coculture Techniques with chemical compounds

  • In conditions which demonstrate interferon-induced transfer of viral resistance, exposure of co-cultures of mouse myocardial cells and WISH cells to either human interferon or noradrenaline caused an increased beat frequency in the myocardial cells and development of antiviral activity in WISH cells, respectively [28].
  • Since both beta receptors and cholera toxin-stimulated adenylate cyclase activities are present in C6/B104 cocultures, we conclude that the beta receptor/adenylate cyclase transduction mechanism in cocultured C6 cells is uncoupled [29].
  • The stable products of the L-arginine pathway, NO2- and NO3-, were incapable of causing cytostasis under coculture conditions [30].
  • The inhibitory effect of previous palmitate was similar when co-culture was performed with 5.5, 11, or 27 mM glucose [31].
  • The cocultivation of spleen cells from BCGcw-immunized rats with indomethacin resulted in a 30-40% restoration of the blastogenesis response [32].

Gene context of Coculture Techniques

  • Additionally, in cocultures in which spleen cells were derived from receptor-deficient mice and osteoblasts were from wild-type mice and vice versa, we identified that the target cells for IFN-gamma inhibition of OCL formation were the hemopoietic cells [33].
  • The inhibitory effect of IL-18 was limited to the early phase of the cocultures, which coincides with proliferation of hemopoietic precursors [33].
  • In contrast, both CD80 and CD86 were expressed in allogeneic CD4(+) T cell-EC cocultures [34].
  • In a subset of these normolipidemic patients (n = 5), the PON activity was low (48+/-6.6 versus 98+/-17 U/ml for controls; P < 0.009), despite similar normal HDL levels, and the HDL from these patients failed to protect against LDL oxidation in co-cultures of human artery wall cells [35].
  • High levels of RANTES were present in platelet-HIMEC cocultures and platelets were identified as the source of this chemokine, which mediated T-cell adhesion to HIMEC [36].

Analytical, diagnostic and therapeutic context of Coculture Techniques


  1. Evidence that transforming growth factor-beta is a hormonally regulated negative growth factor in human breast cancer cells. Knabbe, C., Lippman, M.E., Wakefield, L.M., Flanders, K.C., Kasid, A., Derynck, R., Dickson, R.B. Cell (1987) [Pubmed]
  2. Infection of Macaca nemestrina by human immunodeficiency virus type-1. Agy, M.B., Frumkin, L.R., Corey, L., Coombs, R.W., Wolinsky, S.M., Koehler, J., Morton, W.R., Katze, M.G. Science (1992) [Pubmed]
  3. Induction of somatic mutation in a human B cell line in vitro. Denépoux, S., Razanajaona, D., Blanchard, D., Meffre, G., Capra, J.D., Banchereau, J., Lebecque, S. Immunity (1997) [Pubmed]
  4. Neutrophils from human immunodeficiency virus (HIV)-seronegative donors induce HIV replication from HIV-infected patients' mononuclear cells and cell lines: an in vitro model of HIV transmission facilitated by Chlamydia trachomatis. Ho, J.L., He, S., Hu, A., Geng, J., Basile, F.G., Almeida, M.G., Saito, A.Y., Laurence, J., Johnson, W.D. J. Exp. Med. (1995) [Pubmed]
  5. Infection of human synovial cells by human T cell lymphotropic virus type I. Proliferation and granulocyte/macrophage colony-stimulating factor production by synovial cells. Sakai, M., Eguchi, K., Terada, K., Nakashima, M., Yamashita, I., Ida, H., Kawabe, Y., Aoyagi, T., Takino, H., Nakamura, T. J. Clin. Invest. (1993) [Pubmed]
  6. mRNAs encoding a von Ebner's-like protein and the Huntington disease protein are induced in rat male germ cells by Sertoli cells. Syed, V., Gomez, E., Hecht, N.B. J. Biol. Chem. (1999) [Pubmed]
  7. Influence of organic nutrients and cocultures on the competitive behavior of 1,2-dichloroethane-degrading bacteria. van den Wijngaard, A.J., van der Kleij, R.G., Doornweerd, R.E., Janssen, D.B. Appl. Environ. Microbiol. (1993) [Pubmed]
  8. Regulation of monocyte MMP-9 production by TNF-alpha and a tumour-derived soluble factor (MMPSF). Leber, T.M., Balkwill, F.R. Br. J. Cancer (1998) [Pubmed]
  9. Direct action of serotonin on prolactin, growth hormone, corticotropin and luteinizing hormone release in cocultures of anterior and posterior pituitary lobes: autocrine and/or paracrine action of vasoactive intestinal peptide. Balsa, J.A., Sánchez-Franco, F., Pazos, F., Lara, J.I., Lorenzo, M.J., Maldonado, G., Cacicedo, L. Neuroendocrinology (1998) [Pubmed]
  10. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Lacey, D.L., Timms, E., Tan, H.L., Kelley, M.J., Dunstan, C.R., Burgess, T., Elliott, R., Colombero, A., Elliott, G., Scully, S., Hsu, H., Sullivan, J., Hawkins, N., Davy, E., Capparelli, C., Eli, A., Qian, Y.X., Kaufman, S., Sarosi, I., Shalhoub, V., Senaldi, G., Guo, J., Delaney, J., Boyle, W.J. Cell (1998) [Pubmed]
  11. Characterization of rat T cell precursors sorted by chemotactic migration toward thymotaxin. Deugnier, M.A., Imhof, B.A., Bauvois, B., Dunon, D., Denoyelle, M., Thiery, J.P. Cell (1989) [Pubmed]
  12. Complementation of mutations in the LDL pathway of receptor-mediated endocytosis by cocultivation of LDL receptor-defective hamster cell mutants. Krieger, M. Cell (1983) [Pubmed]
  13. Glutamate-mediated astrocyte-neuron signalling. Parpura, V., Basarsky, T.A., Liu, F., Jeftinija, K., Jeftinija, S., Haydon, P.G. Nature (1994) [Pubmed]
  14. NF-kappaB and p53 are the dominant apoptosis-inducing transcription factors elicited by the HIV-1 envelope. Perfettini, J.L., Roumier, T., Castedo, M., Larochette, N., Boya, P., Raynal, B., Lazar, V., Ciccosanti, F., Nardacci, R., Penninger, J., Piacentini, M., Kroemer, G. J. Exp. Med. (2004) [Pubmed]
  15. Human cytomegalovirus-stimulated peripheral blood mononuclear cells induce HIV-1 replication via a tumor necrosis factor-alpha-mediated mechanism. Peterson, P.K., Gekker, G., Chao, C.C., Hu, S.X., Edelman, C., Balfour, H.H., Verhoef, J. J. Clin. Invest. (1992) [Pubmed]
  16. Selective neuronal toxicity of cocaine in embryonic mouse brain cocultures. Nassogne, M.C., Evrard, P., Courtoy, P.J. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  17. Quantitative distinction of cisplatin-sensitive and -resistant mouse fibrosarcoma cells grown in multicell tumor spheroids. Frenzel, K.R., Saller, R.M., Kummermehr, J., Schultz-Hector, S. Cancer Res. (1995) [Pubmed]
  18. Astrocytes regulate N-methyl-D-aspartate receptor subunit composition increasing neuronal sensitivity to excitotoxicity. Daniels, M., Brown, D.R. J. Biol. Chem. (2001) [Pubmed]
  19. Activation-induced apoptosis in human macrophages: developmental regulation of a novel cell death pathway by macrophage colony-stimulating factor and interferon gamma. Munn, D.H., Beall, A.C., Song, D., Wrenn, R.W., Throckmorton, D.C. J. Exp. Med. (1995) [Pubmed]
  20. Differential effects of Notch ligands Delta-1 and Jagged-1 in human lymphoid differentiation. Jaleco, A.C., Neves, H., Hooijberg, E., Gameiro, P., Clode, N., Haury, M., Henrique, D., Parreira, L. J. Exp. Med. (2001) [Pubmed]
  21. Effect of microtubule inhibitors on malignant invasion in vitro. Mareel, M.M., De Brabander, M.J. J. Natl. Cancer Inst. (1978) [Pubmed]
  22. New mechanism for foam cell generation in atherosclerotic lesions. Curtiss, L.K., Black, A.S., Takagi, Y., Plow, E.F. J. Clin. Invest. (1987) [Pubmed]
  23. Retinoid protection against x-ray-induced chromatid damage in human peripheral blood lymphocytes. Sanford, K.K., Parshad, R., Price, F.M., Tarone, R.E., Kraemer, K.H. J. Clin. Invest. (1992) [Pubmed]
  24. CCL19 and CCL21 induce a potent proinflammatory differentiation program in licensed dendritic cells. Marsland, B.J., Bättig, P., Bauer, M., Ruedl, C., Lässing, U., Beerli, R.R., Dietmeier, K., Ivanova, L., Pfister, T., Vogt, L., Nakano, H., Nembrini, C., Saudan, P., Kopf, M., Bachmann, M.F. Immunity (2005) [Pubmed]
  25. Cytokines and arachidonic metabolites produced during human immunodeficiency virus (HIV)-infected macrophage-astroglia interactions: implications for the neuropathogenesis of HIV disease. Genis, P., Jett, M., Bernton, E.W., Boyle, T., Gelbard, H.A., Dzenko, K., Keane, R.W., Resnick, L., Mizrachi, Y., Volsky, D.J. J. Exp. Med. (1992) [Pubmed]
  26. Interleukin (IL)-6 induction of osteoclast differentiation depends on IL-6 receptors expressed on osteoblastic cells but not on osteoclast progenitors. Udagawa, N., Takahashi, N., Katagiri, T., Tamura, T., Wada, S., Findlay, D.M., Martin, T.J., Hirota, H., Taga, T., Kishimoto, T., Suda, T. J. Exp. Med. (1995) [Pubmed]
  27. MyD88 but not TRIF is essential for osteoclastogenesis induced by lipopolysaccharide, diacyl lipopeptide, and IL-1alpha. Sato, N., Takahashi, N., Suda, K., Nakamura, M., Yamaki, M., Ninomiya, T., Kobayashi, Y., Takada, H., Shibata, K., Yamamoto, M., Takeda, K., Akira, S., Noguchi, T., Udagawa, N. J. Exp. Med. (2004) [Pubmed]
  28. Common pathways of interferon and hormonal action. Blalock, J.E., Stanton, J.D. Nature (1980) [Pubmed]
  29. Cellular interactions uncouple beta-adrenergic receptors from adenylate cyclase. Ciment, G., de Vellis, J. Science (1978) [Pubmed]
  30. Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells. Stuehr, D.J., Nathan, C.F. J. Exp. Med. (1989) [Pubmed]
  31. Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle. Zhou, Y.P., Grill, V.E. J. Clin. Invest. (1994) [Pubmed]
  32. Modification of in vitro and in vivo BCG cell wall-induced immunosuppression by treatment with chemotherapeutic agents or indomethacin. DeSilva, M.A., Wepsic, H.T., Mizushima, Y., Nikcevich, D.A., Larson, C.H. J. Natl. Cancer Inst. (1985) [Pubmed]
  33. Interleukin-18 (interferon-gamma-inducing factor) is produced by osteoblasts and acts via granulocyte/macrophage colony-stimulating factor and not via interferon-gamma to inhibit osteoclast formation. Udagawa, N., Horwood, N.J., Elliott, J., Mackay, A., Owens, J., Okamura, H., Kurimoto, M., Chambers, T.J., Martin, T.J., Gillespie, M.T. J. Exp. Med. (1997) [Pubmed]
  34. Endothelial cells modify the costimulatory capacity of transmigrating leukocytes and promote CD28-mediated CD4(+) T cell alloactivation. Denton, M.D., Geehan, C.S., Alexander, S.I., Sayegh, M.H., Briscoe, D.M. J. Exp. Med. (1999) [Pubmed]
  35. Mildly oxidized LDL induces an increased apolipoprotein J/paraoxonase ratio. Navab, M., Hama-Levy, S., Van Lenten, B.J., Fonarow, G.C., Cardinez, C.J., Castellani, L.W., Brennan, M.L., Lusis, A.J., Fogelman, A.M., La Du, B.N. J. Clin. Invest. (1997) [Pubmed]
  36. Platelets trigger a CD40-dependent inflammatory response in the microvasculature of inflammatory bowel disease patients. Danese, S., de la Motte, C., Sturm, A., Vogel, J.D., West, G.A., Strong, S.A., Katz, J.A., Fiocchi, C. Gastroenterology (2003) [Pubmed]
  37. Anti-inflammatory HDL becomes pro-inflammatory during the acute phase response. Loss of protective effect of HDL against LDL oxidation in aortic wall cell cocultures. Van Lenten, B.J., Hama, S.Y., de Beer, F.C., Stafforini, D.M., McIntyre, T.M., Prescott, S.M., La Du, B.N., Fogelman, A.M., Navab, M. J. Clin. Invest. (1995) [Pubmed]
  38. Local pH elevation mediated by the intrabacterial urease of Helicobacter pylori cocultured with gastric cells. Athmann, C., Zeng, N., Kang, T., Marcus, E.A., Scott, D.R., Rektorschek, M., Buhmann, A., Melchers, K., Sachs, G. J. Clin. Invest. (2000) [Pubmed]
  39. Choline acetyltransferase activity of spinal cord cell cultures increased by co-culture with muscle and by muscle-conditioned medium. Giller, E.L., Neale, J.H., Bullock, P.N., Schrier, B.K., Nelson, P.G. J. Cell Biol. (1977) [Pubmed]
  40. Interactions between human tumor cells and fibroblasts stimulate hyaluronate synthesis. Knudson, W., Biswas, C., Toole, B.P. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  41. Complement and virus-specific antibody-dependent infection of normal B lymphocytes by human immunodeficiency virus type 1. Gras, G., Richard, Y., Roques, P., Olivier, R., Dormont, D. Blood (1993) [Pubmed]
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