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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Randomized, double-blind study of cefotetan and cefoxitin in post-cesarean section endometritis.

OBJECTIVE: The hypothesis of the study is that cefotetan and cefoxitin will be equally efficacious and safe in the treatment of post-cesarean section endometritis. STUDY DESIGN: In a double-blind, randomized manner 140 patients with post-cesarean section endometritis were treated with cefotetan, 2 gm intravenously every 12 hours, or cefoxitin, 2 gm intravenously every 6 hours. They were followed prospectively for clinical response and side effects. Cure rates between the two groups were compared with the chi 2 test. RESULTS: The cure rates were 83% for cefotetan and 79% for cefoxitin (p = 0.56). No patient required a change in therapy due to adverse effects, and no abnormal bleeding occurred. CONCLUSION: In this study cefotetan and cefoxitin appeared equally effective in treating endometritis with no difference in side effects or complications.[1]


  1. Randomized, double-blind study of cefotetan and cefoxitin in post-cesarean section endometritis. MacGregor, R.R., Graziani, A.L., Samuels, P. Am. J. Obstet. Gynecol. (1992) [Pubmed]
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