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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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A putative ATP-dependent RNA helicase involved in Saccharomyces cerevisiae ribosome assembly.

We have isolated a cold-sensitive mutant of Saccharomyces cerevisiae in which there is a deficit of 60S ribosomal subunits. Cold sensitivity and the assembly defect are recessive and cosegregate, defining a single essential gene that we designated DRS1 (deficiency of ribosomal subunits). The wild-type DRS1 gene was cloned by complementation of the cold-sensitive phenotype of drs1. Sequence analysis reveals a high degree of similarity to a family of proteins that are thought to function as ATP-dependent RNA helicases. Pulse-chase analysis of ribosomal RNA synthesis and processing indicates that the drs1 mutant accumulates the 27S precursor of the mature 25S rRNA. These results suggest that, as in pre-mRNA splicing, RNA helicase activities are involved in ribosomal RNA processing.[1]

References

  1. A putative ATP-dependent RNA helicase involved in Saccharomyces cerevisiae ribosome assembly. Ripmaster, T.L., Vaughn, G.P., Woolford, J.L. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
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