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Gene Review

DRS1  -  Drs1p

Saccharomyces cerevisiae S288c

Synonyms: ATP-dependent RNA helicase DRS1, Deficiency of ribosomal subunits protein 1, L1345, YLL008W
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High impact information on DRS1


Biological context of DRS1

  • To identify new gene products that participate in ribosome biogenesis, we carried out a screen for mutations that result in lethality in combination with mutations in DRS1, a Saccharomyces cerevisiae nucleolar DEAD-box protein required for synthesis of 60S ribosomal subunits [4].

Other interactions of DRS1

  • Thus Nop7p, like Drs1p, is required for essential steps leading to synthesis of 60S ribosomal subunits [4].


  1. A putative ATP-dependent RNA helicase involved in Saccharomyces cerevisiae ribosome assembly. Ripmaster, T.L., Vaughn, G.P., Woolford, J.L. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  2. DRS1 to DRS7, novel genes required for ribosome assembly and function in Saccharomyces cerevisiae. Ripmaster, T.L., Vaughn, G.P., Woolford, J.L. Mol. Cell. Biol. (1993) [Pubmed]
  3. Molecular cloning and primary structure of cDNA encoding the catalytic domain of rat liver aspartyl-tRNA synthetase. Mirande, M., Waller, J.P. J. Biol. Chem. (1989) [Pubmed]
  4. Saccharomyces cerevisiae nucleolar protein Nop7p is necessary for biogenesis of 60S ribosomal subunits. Adams, C.C., Jakovljevic, J., Roman, J., Harnpicharnchai, P., Woolford, J.L. RNA (2002) [Pubmed]
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