- Maspardin is mutated in mast syndrome, a complicated form of hereditary spastic paraplegia associated with dementia. Simpson, M.A., Cross, H., Proukakis, C., Pryde, A., Hershberger, R., Chatonnet, A., Patton, M.A., Crosby, A.H. Am. J. Hum. Genet. (2003)