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MeSH Review

Corpus Callosum

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Disease relevance of Corpus Callosum


Psychiatry related information on Corpus Callosum


High impact information on Corpus Callosum

  • Developing axons of the corpus callosum of mice are guided across the cerebral midline by a slinglike glial structure that forms transiently between the hemispheres [10].
  • Patients in PVS revealed a significantly higher frequency of corpus callosum, corona radiata, and dorsolateral brainstem injuries than did patients who recovered [11].
  • Surprisingly, many of the axon guidance defects present in the L1 knockout mice, such as abnormal corticospinal tract and corpus callosum, were not observed [12].
  • We show that the GFAP network is disrupted in astrocytes that normally coexpress vimentin and GFAP, e.g., those of the corpus callosum or the Bergmann glia of cerebellum [13].
  • While mice deficient in Nuk exhibit defects in pathfinding of anterior commissure axons, sek4 mutants have defects in corpus callosum formation [14].

Chemical compound and disease context of Corpus Callosum


Biological context of Corpus Callosum


Anatomical context of Corpus Callosum


Associations of Corpus Callosum with chemical compounds

  • The corpus callosum atrophy was accompanied by a decreased mean cortical glucose metabolic rate, predominantly in the frontal region of the cortex, and poor performance on the picture arrangement subtest of the Wechsler Adult Intelligence Scale and the verbal fluency task [30].
  • Expression of the dopamine D3 receptor (D3r) was found in primary mixed glial cultures from newborn brain and in the corpus callosum in vivo during the peak of myelination [28].
  • To trace the implanted cells, they were stained with the carbocyanine vital dye 1,1'-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate before injecting them into the white matter above the corpus callosum [31].
  • When measurements were compared among 44 patients, whose cerebral speech dominance had been determined by the intracarotid injection of sodium amytal, the area of the corpus callosum was significantly greater in patients with right-hemisphere cerebral speech dominance [32].
  • We observed variations in fractional anisotropy and mean diffusivity over the considered developmental period in most bundles (corpus callosum, cerebellar peduncles, cortico-spinal tract, spino-thalamic tract, capsules, radiations, longitudinal and uncinate fascicles, cingulum) [33].

Gene context of Corpus Callosum

  • Newborn Nfia(-/-) animals lack a corpus callosum and show ventricular dilation indicating early hydrocephalus [5].
  • These results are consistent with deficient auditory interhemispheric transfer in patients with a PAX6 mutation, which may be attributable to structural and/or functional abnormalities of the anterior commisure and corpus callosum, although the exact contribution of these two formations to our findings remains unclear [34].
  • The axon guidance defect of the corpus callosum in the jsap1-/- brain was correlated with the misplacement of glial sling cells, which reverted to their normal position after the transgenic expression of JNK interacting protein 1(JIP1) [35].
  • The transgenic JIP1 partially rescued the axon guidance defect of the corpus callosum and the anterior commissure of the jsap1-/- brain [35].
  • Using a multiple tissue expression (MTE) array containing 20 different human brain regions, the highest levels of both SFT/UbcH5A and DMT1 mRNA are detected in the corpus callosum and cerebellum [36].

Analytical, diagnostic and therapeutic context of Corpus Callosum


  1. The K-Cl cotransporter KCC3 is mutant in a severe peripheral neuropathy associated with agenesis of the corpus callosum. Howard, H.C., Mount, D.B., Rochefort, D., Byun, N., Dupré, N., Lu, J., Fan, X., Song, L., Rivière, J.B., Prévost, C., Horst, J., Simonati, A., Lemcke, B., Welch, R., England, R., Zhan, F.Q., Mercado, A., Siesser, W.B., George, A.L., McDonald, M.P., Bouchard, J.P., Mathieu, J., Delpire, E., Rouleau, G.A. Nat. Genet. (2002) [Pubmed]
  2. Alcohol inhibits cell-cell adhesion mediated by human L1. Ramanathan, R., Wilkemeyer, M.F., Mittal, B., Perides, G., Charness, M.E. J. Cell Biol. (1996) [Pubmed]
  3. Large-scale deletions and SMADIP1 truncating mutations in syndromic Hirschsprung disease with involvement of midline structures. Amiel, J., Espinosa-Parrilla, Y., Steffann, J., Gosset, P., Pelet, A., Prieur, M., Boute, O., Choiset, A., Lacombe, D., Philip, N., Le Merrer, M., Tanaka, H., Till, M., Touraine, R., Toutain, A., Vekemans, M., Munnich, A., Lyonnet, S. Am. J. Hum. Genet. (2001) [Pubmed]
  4. Damage-induced neuronal endopeptidase (DINE) is a unique metallopeptidase expressed in response to neuronal damage and activates superoxide scavengers. Kiryu-Seo, S., Sasaki, M., Yokohama, H., Nakagomi, S., Hirayama, T., Aoki, S., Wada, K., Kiyama, H. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  5. Disruption of the murine nuclear factor I-A gene (Nfia) results in perinatal lethality, hydrocephalus, and agenesis of the corpus callosum. das Neves, L., Duchala, C.S., Tolentino-Silva, F., Haxhiu, M.A., Colmenares, C., Macklin, W.B., Campbell, C.E., Butz, K.G., Gronostajski, R.M., Godinho, F. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  6. Posterior corpus callosum and interhemispheric transfer of somatosensory information: an fMRI and neuropsychological study of a partially callosotomized patient. Fabri, M., Polonara, G., Del Pesce, M., Quattrini, A., Salvolini, U., Manzoni, T. Journal of cognitive neuroscience. (2001) [Pubmed]
  7. Corpus callosum morphology in children with Tourette syndrome and attention deficit hyperactivity disorder. Baumgardner, T.L., Singer, H.S., Denckla, M.B., Rubin, M.A., Abrams, M.T., Colli, M.J., Reiss, A.L. Neurology (1996) [Pubmed]
  8. The relation of planum temporale asymmetry and morphology of the corpus callosum to handedness, gender, and dyslexia: a review of the evidence. Beaton, A.A. Brain and language. (1997) [Pubmed]
  9. Speech perception and auditory P300 potentials after section of the posterior half of the truncus of the corpus callosum. Kaga, K., Shindo, M., Gotoh, O., Tamura, A. Brain topography. (1990) [Pubmed]
  10. Postnatally induced formation of the corpus callosum in acallosal mice on glia-coated cellulose bridges. Silver, J., Ogawa, M.Y. Science (1983) [Pubmed]
  11. Prediction of recovery from post-traumatic vegetative state with cerebral magnetic-resonance imaging. Kampfl, A., Schmutzhard, E., Franz, G., Pfausler, B., Haring, H.P., Ulmer, H., Felber, S., Golaszewski, S., Aichner, F. Lancet (1998) [Pubmed]
  12. Brain development in mice lacking L1-L1 homophilic adhesion. Itoh, K., Cheng, L., Kamei, Y., Fushiki, S., Kamiguchi, H., Gutwein, P., Stoeck, A., Arnold, B., Altevogt, P., Lemmon, V. J. Cell Biol. (2004) [Pubmed]
  13. Disrupted glial fibrillary acidic protein network in astrocytes from vimentin knockout mice. Galou, M., Colucci-Guyon, E., Ensergueix, D., Ridet, J.L., Gimenez y Ribotta, M., Privat, A., Babinet, C., Dupouey, P. J. Cell Biol. (1996) [Pubmed]
  14. Sek4 and Nuk receptors cooperate in guidance of commissural axons and in palate formation. Orioli, D., Henkemeyer, M., Lemke, G., Klein, R., Pawson, T. EMBO J. (1996) [Pubmed]
  15. Insulin-like growth factor-1 inhibits mature oligodendrocyte apoptosis during primary demyelination. Mason, J.L., Ye, P., Suzuki, K., D'Ercole, A.J., Matsushima, G.K. J. Neurosci. (2000) [Pubmed]
  16. Regional axonal loss in the corpus callosum correlates with cerebral white matter lesion volume and distribution in multiple sclerosis. Evangelou, N., Konz, D., Esiri, M.M., Smith, S., Palace, J., Matthews, P.M. Brain (2000) [Pubmed]
  17. Inborn errors of metabolism: a cause of abnormal brain development. Nissenkorn, A., Michelson, M., Ben-Zeev, B., Lerman-Sagie, T. Neurology (2001) [Pubmed]
  18. Inappropriate secretion of antiduretic hormone, hypertension, and hypoplastic corpus callosum. Fyhrquist, F., Holmberg, C., Perheentupa, J., Wallenius, M. J. Clin. Endocrinol. Metab. (1977) [Pubmed]
  19. Atrophy of the corpus callosum associated with a decrease in cortical benzodiazepine receptor in large cerebral arterial occlusive diseases. Yamauchi, H., Fukuyama, H., Dong, Y., Nabatame, H., Nagahama, Y., Nishizawa, S., Konishi, J., Shio, H. J. Neurol. Neurosurg. Psychiatr. (2000) [Pubmed]
  20. Growth, adipose, brain, and skin alterations resulting from targeted disruption of the mouse peroxisome proliferator-activated receptor beta(delta). Peters, J.M., Lee, S.S., Li, W., Ward, J.M., Gavrilova, O., Everett, C., Reitman, M.L., Hudson, L.D., Gonzalez, F.J. Mol. Cell. Biol. (2000) [Pubmed]
  21. The site of a missense mutation in the extracellular Ig or FN domains of L1CAM influences infant mortality and the severity of X linked hydrocephalus. Michaelis, R.C., Du, Y.Z., Schwartz, C.E. J. Med. Genet. (1998) [Pubmed]
  22. Mutation of the Emx-1 homeobox gene disrupts the corpus callosum. Qiu, M., Anderson, S., Chen, S., Meneses, J.J., Hevner, R., Kuwana, E., Pedersen, R.A., Rubenstein, J.L. Dev. Biol. (1996) [Pubmed]
  23. Phosphorylation of cyclic adenosine monophosphate response element binding protein in oligodendrocytes in the corpus callosum after focal cerebral ischemia in the rat. Tanaka, K., Nogawa, S., Ito, D., Suzuki, S., Dembo, T., Kosakai, A., Fukuuchi, Y. J. Cereb. Blood Flow Metab. (2001) [Pubmed]
  24. Differential susceptibility of senile and lesion-induced astrogliosis to phosphatidylserine. Jegliński, W., Pepeu, G., Oderfeld-Nowak, B. Neurobiol. Aging (1997) [Pubmed]
  25. Recognition of Bergmann glial and ependymal cells in the mouse nervous system by monoclonal antibody. Sommer, I., Lagenaur, C., Schachner, M. J. Cell Biol. (1981) [Pubmed]
  26. MARCKS deficiency in mice leads to abnormal brain development and perinatal death. Stumpo, D.J., Bock, C.B., Tuttle, J.S., Blackshear, P.J. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  27. Neurotransmitter receptors and voltage-dependent Ca2+ channels encoded by mRNA from the adult corpus callosum. Matute, C., Miledi, R. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  28. Identification of the dopamine D3 receptor in oligodendrocyte precursors: potential role in regulating differentiation and myelin formation. Bongarzone, E.R., Howard, S.G., Schonmann, V., Campagnoni, A.T. J. Neurosci. (1998) [Pubmed]
  29. X-linked lissencephaly with absent corpus callosum and ambiguous genitalia (XLAG): clinical, magnetic resonance imaging, and neuropathological findings. Bonneau, D., Toutain, A., Laquerrière, A., Marret, S., Saugier-Veber, P., Barthez, M.A., Radi, S., Biran-Mucignat, V., Rodriguez, D., Gélot, A. Ann. Neurol. (2002) [Pubmed]
  30. Atrophy of the corpus callosum, cognitive impairment, and cortical hypometabolism in progressive supranuclear palsy. Yamauchi, H., Fukuyama, H., Nagahama, Y., Katsumi, Y., Dong, Y., Konishi, J., Kimura, J. Ann. Neurol. (1997) [Pubmed]
  31. Migratory pattern of fetal rat brain cells and human glioma cells in the adult rat brain. Pedersen, P.H., Marienhagen, K., Mørk, S., Bjerkvig, R. Cancer Res. (1993) [Pubmed]
  32. The corpus callosum is larger with right-hemisphere cerebral speech dominance. O'Kusky, J., Strauss, E., Kosaka, B., Wada, J., Li, D., Druhan, M., Petrie, J. Ann. Neurol. (1988) [Pubmed]
  33. Assessment of the early organization and maturation of infants' cerebral white matter fiber bundles: A feasibility study using quantitative diffusion tensor imaging and tractography. Dubois, J., Hertz-Pannier, L., Dehaene-Lambertz, G., Cointepas, Y., Le Bihan, D. Neuroimage (2006) [Pubmed]
  34. Deficient auditory interhemispheric transfer in patients with PAX6 mutations. Bamiou, D.E., Musiek, F.E., Sisodiya, S.M., Free, S.L., Davies, R.A., Moore, A., van Heyningen, V., Luxon, L.M. Ann. Neurol. (2004) [Pubmed]
  35. The axon guidance defect of the telencephalic commissures of the JSAP1-deficient brain was partially rescued by the transgenic expression of JIP1. Ha, H.Y., Cho, I.H., Lee, K.W., Lee, K.W., Song, J.Y., Kim, K.S., Yu, Y.M., Lee, J.K., Song, J.S., Yang, S.D., Shin, H.S., Han, P.L. Dev. Biol. (2005) [Pubmed]
  36. Developmental, regional, and cellular expression of SFT/UbcH5A and DMT1 mRNA in brain. Knutson, M., Menzies, S., Connor, J., Wessling-Resnick, M. J. Neurosci. Res. (2004) [Pubmed]
  37. Effects of anterior corpus callosum section on cortical glucose utilization in baboons. A sequential positron emission tomography study. Yamaguchi, T., Kunimoto, M., Pappata, S., Chavoix, C., Riche, D., Chevalier, L., Mazoyer, B., Mazière, M., Naquet, R., Baron, J.C. Brain (1990) [Pubmed]
  38. Corpus callosum atrophy is a possible indicator of region- and cell type-specific neuronal degeneration in Alzheimer disease: a magnetic resonance imaging analysis. Hampel, H., Teipel, S.J., Alexander, G.E., Horwitz, B., Teichberg, D., Schapiro, M.B., Rapoport, S.I. Arch. Neurol. (1998) [Pubmed]
  39. Moderate prenatal ethanol exposure interacts with strain in affecting brain development in BALB/c and C57BL/6 mice. Wainwright, P., Gagnon, M. Exp. Neurol. (1985) [Pubmed]
  40. Randomized study of brachytherapy in the initial management of patients with malignant astrocytoma. Laperriere, N.J., Leung, P.M., McKenzie, S., Milosevic, M., Wong, S., Glen, J., Pintilie, M., Bernstein, M. Int. J. Radiat. Oncol. Biol. Phys. (1998) [Pubmed]
  41. Corpus callosotomy with radiosurgery. Pendl, G., Eder, H.G., Schroettner, O., Leber, K.A. Neurosurgery (1999) [Pubmed]
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