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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Control of dendritic cell cross-presentation by the major histocompatibility complex class I cytoplasmic domain.

Dendritic cells (DCs) can present extracellularly derived antigens in the context of major histocompatibility complex (MHC) class I molecules, a process called cross-presentation. Although recognized to be important for priming of T cell responses to many viral, bacterial and tumor antigens, the mechanistic details of this alternative antigen-presentation pathway are poorly understood. We demonstrate here the existence of an endolysosomal compartment in DCs where exogenously derived peptides can be acquired for presentation to T cells, and show that the MHC class I cytoplasmic domain contains a tyrosine-based targeting signal required for routing MHC class I molecules through these compartments. We also report that transgenic mice expressing H-2K(b) with a tyrosine mutation mount inferior H-2K(b)-restricted cytotoxic T lymphocyte responses against two immunodominant viral epitopes, providing evidence of a crucial function for cross-priming in antiviral immunity.[1]

References

  1. Control of dendritic cell cross-presentation by the major histocompatibility complex class I cytoplasmic domain. Lizée, G., Basha, G., Tiong, J., Julien, J.P., Tian, M., Biron, K.E., Jefferies, W.A. Nat. Immunol. (2003) [Pubmed]
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