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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

S-nitrosylation of NSF controls membrane trafficking.

Nitric oxide is a diffusible molecule with profound effects on regulated exocytosis in several biological systems-however, the molecular targets remain elusive. In this issue of Cell, Matsushita et al. report that in aortic endothelial cells, S-nitrosylation of NSF, an ATPase essential for the activation of the membranefusion machinery, inhibits the exocytosis of Weibel-Palade bodies, secretory granules containing a cocktail of mediators essential to the regulation of vascular vessel tone.[1]


  1. S-nitrosylation of NSF controls membrane trafficking. Söllner, T.H., Sequeira, S. Cell (2003) [Pubmed]
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