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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Oxygen? No thanks, I'm on a diet.

In yeast and worms, mutations that extend longevity appear to simulate starvation conditions. The daf-2 pathway in worms plays a major role in life-span extension and in entry into the starvation-resistant and low-metabolism dauer phase. In a recent study published in Science Express on 13 June 2002, researchers screened for Caenorhabditis elegans mutants that survive in a low-oxygen environment and identified a number of daf-2 mutants that are resistant to hypoxia. The implications of these results are discussed in this Perspective.[1]


  1. Oxygen? No thanks, I'm on a diet. Longo, V.D. Science of aging knowledge environment [electronic resource] : SAGE KE (2002) [Pubmed]
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