- A new class of potent vascular endothelial growth factor receptor tyrosine kinase inhibitors: structure-activity relationships for a series of 9-alkoxymethyl-12-(3-hydroxypropyl)indeno[2,1-a]pyrrolo[3,4-c]carbazole-5-ones and the identification of CEP-5214 and its dimethylglycine ester prodrug clinical candidate CEP-7055. Gingrich, D.E., Reddy, D.R., Iqbal, M.A., Singh, J., Aimone, L.D., Angeles, T.S., Albom, M., Yang, S., Ator, M.A., Meyer, S.L., Robinson, C., Ruggeri, B.A., Dionne, C.A., Vaught, J.L., Mallamo, J.P., Hudkins, R.L. J. Med. Chem. (2003)