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Serra-Mestres, J. et al.

Serra-Mestres, Ring, Costa, Gacinovic, Walker, Lees, Robertson, Trimble,

Dopamine transporter binding in Gilles de la Tourette syndrome: a [123I]FP-CIT/SPECT study.

OBJECTIVE: To investigate dopamine transporter binding in Gilles de la Tourette syndrome ( GTS) with SPECT and [123I]FP-CIT. METHOD: Ten neuroleptic naÃ¯ve/free patients with GTS, and 10 age- and gender-matched normal volunteers were studied. Subjects were clinically evaluated. GTS severity and affective symptoms were measured and the presence of GTS-related behaviours were recorded. RESULTS: The GTS group showed significantly higher binding in both caudate and putamen nuclei than the controls. No associations were found between striatal binding ratios and measures of affect or GTS-related behaviours. CONCLUSION: Patients with GTS show higher striatal binding of FP- CIT to the striatum in comparison with age- and gender-matched control subjects, indicating that dopamine transporter abnormalities are involved in the pathophysiology of GTS. These abnormalities appear to be distributed across both caudate and putamen.[1]

References

Dopamine transporter binding in Gilles de la Tourette syndrome: a [123I]FP-CIT/SPECT study. Serra-Mestres, J., Ring, H.A., Costa, D.C., Gacinovic, S., Walker, Z., Lees, A.J., Robertson, M.M., Trimble, M.R. Acta psychiatrica Scandinavica. (2004) [Pubmed]

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