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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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A breath of fresh air for cyclin D/Cdk4: triggering growth via Hph.

Activation of Cyclin D/Cdk4 stimulates progression through the G1-S phase of the cell cycle in many organisms. In Drosophila, Cyclin D/Cdk4 also induces cell growth independently of cell cycle progression. In this issue of Developmental Cell, Frei and Edgar reveal that Cyclin D/Cdk4- stimulated growth requires Hph, a prolyl hydroxylase that is a key component of a cell's ability to respond to hypoxia.[1]

References

  1. A breath of fresh air for cyclin D/Cdk4: triggering growth via Hph. Duronio, R.J. Dev. Cell (2004) [Pubmed]
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