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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Hph  -  HIF prolyl hydroxylase

Drosophila melanogaster

Synonyms: 0303/04, 31543, CG1114, CG14665, CG2676, ...
 
 
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Disease relevance of Hph

  • In this issue of Developmental Cell, Frei and Edgar reveal that Cyclin D/Cdk4-stimulated growth requires Hph, a prolyl hydroxylase that is a key component of a cell's ability to respond to hypoxia [1].
 

High impact information on Hph

  • Strikingly, loss-of-function mutations of sima rescued the developmental defects observed in fatiga mutants and enabled survival to adulthood [2].
  • Epistasis analysis places Hph downstream of CycD/Cdk4 [3].
  • A breath of fresh air for cyclin D/Cdk4: triggering growth via Hph [1].
 

Biological context of Hph

  • These results indicate that the main functions of Fatiga in development, including control of cell size, involve the regulation of dHIF/Sima [2].

References

  1. A breath of fresh air for cyclin D/Cdk4: triggering growth via Hph. Duronio, R.J. Dev. Cell (2004) [Pubmed]
  2. Reversion of lethality and growth defects in Fatiga oxygen-sensor mutant flies by loss of Hypoxia-Inducible Factor-alpha/Sima. Centanin, L., Ratcliffe, P.J., Wappner, P. EMBO Rep. (2005) [Pubmed]
  3. Drosophila cyclin D/Cdk4 requires Hif-1 prolyl hydroxylase to drive cell growth. Frei, C., Edgar, B.A. Dev. Cell (2004) [Pubmed]
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