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Gene Review

CycD  -  Cyclin D

Drosophila melanogaster

Synonyms: CDI3, CG9096, CYCD, Cdi3, Cyc D, ...
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Disease relevance of CycD


High impact information on CycD


Biological context of CycD


Other interactions of CycD

  • Our data suggest that Hph, in addition to its function in hypoxic response, is a regulator of cellular growth and that it is a key mediator for CycD/Cdk4 [8].
  • A breath of fresh air for cyclin D/Cdk4: triggering growth via Hph [2].
  • Drosophila cyclin D/Cdk4 requires Hif-1 prolyl hydroxylase to drive cell growth [8].
  • Here we describe phenotypic consequences of null mutations in Cyclin D, the single D-type cyclin gene in Drosophila [9].
  • Studies of tumor cells show that the p16(ink4a)/cdk4/cyclin D/pRB pathway is mutated in most forms of cancer, suggesting that the deregulation of E2F, and hence the cell cycle, is a common event in tumorigenesis [10].


  1. The Drosophila cyclin D-Cdk4 complex promotes cellular growth. Datar, S.A., Jacobs, H.W., de la Cruz, A.F., Lehner, C.F., Edgar, B.A. EMBO J. (2000) [Pubmed]
  2. A breath of fresh air for cyclin D/Cdk4: triggering growth via Hph. Duronio, R.J. Dev. Cell (2004) [Pubmed]
  3. Hedgehog regulates cell growth and proliferation by inducing Cyclin D and Cyclin E. Duman-Scheel, M., Weng, L., Xin, S., Du, W. Nature (2002) [Pubmed]
  4. The Drosophila mitochondrial ribosomal protein mRpL12 is required for Cyclin D/Cdk4-driven growth. Frei, C., Galloni, M., Hafen, E., Edgar, B.A. EMBO J. (2005) [Pubmed]
  5. Cyclin D/Cdk4: new insights from Drosophila. Frei, C. Cell Cycle (2004) [Pubmed]
  6. Isolation of Drosophila cyclin D, a protein expressed in the morphogenetic furrow before entry into S phase. Finley, R.L., Thomas, B.J., Zipursky, S.L., Brent, R. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  7. The role of RBF in developmentally regulated cell proliferation in the eye disc and in Cyclin D/Cdk4 induced cellular growth. Xin, S., Weng, L., Xu, J., Du, W. Development (2002) [Pubmed]
  8. Drosophila cyclin D/Cdk4 requires Hif-1 prolyl hydroxylase to drive cell growth. Frei, C., Edgar, B.A. Dev. Cell (2004) [Pubmed]
  9. Cyclin D does not provide essential Cdk4-independent functions in Drosophila. Emmerich, J., Meyer, C.A., de la Cruz, A.F., Edgar, B.A., Lehner, C.F. Genetics (2004) [Pubmed]
  10. A genetic screen for modifiers of E2F in Drosophila melanogaster. Staehling-Hampton, K., Ciampa, P.J., Brook, A., Dyson, N. Genetics (1999) [Pubmed]
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