The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Time course and substance P effects on the vascular and morphological changes in adjuvant-induced monoarthritic rats.

The aim of this study is to characterize the time course of the vascular and morphological changes in arthritic rat knee joints induced by Freund's complete adjuvant (FCA), and to investigate the effects of substance P on these changes. Single unilateral intra-articular injections of 0.1 ml FCA produced swelling of the ipsilateral knees for 4 weeks, blood vessel permeability was increased for 1 week, but blood flow was unaffected except for minor bilateral increases on day 28. The ipsilateral knees also showed marked accumulation of immune cells from day 3 to day 28, minor synovial tissue proliferation on week 2, and some cartilage erosions on weeks 1 and 2. Another group of rats was given additional injection of 1 nmol substance P in their adjuvant-treated knees at 4 h prior to assessments of inflammatory parameters on each specified day. This produced further swelling in their ipsilateral knees on day 3 and day 14, blood vessel permeability was augmented in the first 2 weeks, and blood flow was increased throughout the 4 weeks except on day 7. Parallel but smaller increases in vascular permeability and blood flow were also observed in their contralateral knees. Substance P did not affect FCA-induced changes in immune cell infiltration, synovial tissue proliferation, and cartilage erosion. These findings confirm that intra-articular injection of a low dose of FCA could elicit discrete monoarthritis in rat knees, and substance P could exacerbate and spread the early signs of this disease to the contralateral knees.[1]

References

 
WikiGenes - Universities