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Chemical Compound Review

AC1L1VJ4     1-[(17R)-3,17-dihydroxy- 10,13-dimethyl-1,2...

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Disease relevance of Substance P


Psychiatry related information on Substance P

  • We conclude that substance P has an important and specific role in mediating the motivational aspects of opiates and may represent a new pharmacological route for the control of drug abuse [6].
  • The distribution of 3H-substance P receptors suggests that substance P is probably involved in the control of sensory processes such as pain, vision, audition and olfaction [7].
  • A metabolically protected analog of substance P, [pGlu5-MePhe8-MeGly9]SP(5-11) (DiMe-C7), was approximately equipotent with substance P in causing increased locomotor activity after microinfusion into the ventral tegmental area of rat brain, but the effects of DiMe-C7 on behavior were considerably prolonged [8].
  • The influence of substance P on nociception depended on the individual mouse's sensitivity to pain (control response latency) [9].
  • As reviewed in this chapter, the existing preclinical and clinical literature is suggestive of, but not conclusive, concerning a role of substance P and NK(1) receptors in the pathophysiology of depression and/or anxiety disorders [10].

High impact information on Substance P


Chemical compound and disease context of Substance P


Biological context of Substance P


Anatomical context of Substance P


Associations of Substance P with other chemical compounds


Gene context of Substance P


Analytical, diagnostic and therapeutic context of Substance P


  1. Cycloheximide-sensitive synthesis of substance P by isolated dorsal root ganglia. Harmar, A., Schofield, J.G., Keen, P. Nature (1980) [Pubmed]
  2. Amino-aromatic interaction between histidine 197 of the neurokinin-1 receptor and CP 96345. Fong, T.M., Cascieri, M.A., Yu, H., Bansal, A., Swain, C., Strader, C.D. Nature (1993) [Pubmed]
  3. Altered nociception, analgesia and aggression in mice lacking the receptor for substance P. De Felipe, C., Herrero, J.F., O'Brien, J.A., Palmer, J.A., Doyle, C.A., Smith, A.J., Laird, J.M., Belmonte, C., Cervero, F., Hunt, S.P. Nature (1998) [Pubmed]
  4. The control of microvascular permeability and blood pressure by neutral endopeptidase. Lu, B., Figini, M., Emanueli, C., Geppetti, P., Grady, E.F., Gerard, N.P., Ansell, J., Payan, D.G., Gerard, C., Bunnett, N. Nat. Med. (1997) [Pubmed]
  5. A VIP-containing system concentrated in the lumbosacral region of human spinal cord. Anand, P., Gibson, S.J., McGregor, G.P., Blank, M.A., Ghatei, M.A., Bacarese-Hamilton, A.J., Polak, J.M., Bloom, S.R. Nature (1983) [Pubmed]
  6. Rewarding effects of opiates are absent in mice lacking the receptor for substance P. Murtra, P., Sheasby, A.M., Hunt, S.P., De Felipe, C. Nature (2000) [Pubmed]
  7. Autoradiographic distribution of substance P receptors in rat central nervous system. Quirion, R., Shults, C.W., Moody, T.W., Pert, C.B., Chase, T.N., O'Donohue, T.L. Nature (1983) [Pubmed]
  8. Substance P analog, DiMe-C7: evidence for stability in rat brain and prolonged central actions. Eison, A.S., Iversen, S.D., Sandberg, B.E., Watson, S.P., Hanley, M.R., Iversen, L.L. Science (1982) [Pubmed]
  9. Substance P: does it produce analgesia or hyperalgesia? Oehme, P., Hilse, H., Morgenstern, E., Göres, E. Science (1980) [Pubmed]
  10. Neurokinin(1) receptor antagonists as potential antidepressants. Stout, S.C., Owens, M.J., Nemeroff, C.B. Annu. Rev. Pharmacol. Toxicol. (2001) [Pubmed]
  11. Maturation of the mammalian respiratory system. Hilaire, G., Duron, B. Physiol. Rev. (1999) [Pubmed]
  12. Substance P precursor and kininogen: their structures, gene organizations, and regulation. Nakanishi, S. Physiol. Rev. (1987) [Pubmed]
  13. TRPV1+ sensory neurons control beta cell stress and islet inflammation in autoimmune diabetes. Razavi, R., Chan, Y., Afifiyan, F.N., Liu, X.J., Wan, X., Yantha, J., Tsui, H., Tang, L., Tsai, S., Santamaria, P., Driver, J.P., Serreze, D., Salter, M.W., Dosch, H.M. Cell (2006) [Pubmed]
  14. A neuropeptide courier for delta-opioid receptors? Julius, D., Basbaum, A.I. Cell (2005) [Pubmed]
  15. Reduction of cisplatin-induced emesis by a selective neurokinin-1-receptor antagonist. L-754,030 Antiemetic Trials Group. Navari, R.M., Reinhardt, R.R., Gralla, R.J., Kris, M.G., Hesketh, P.J., Khojasteh, A., Kindler, H., Grote, T.H., Pendergrass, K., Grunberg, S.M., Carides, A.D., Gertz, B.J. N. Engl. J. Med. (1999) [Pubmed]
  16. Primary afferent tachykinins are required to experience moderate to intense pain. Cao, Y.Q., Mantyh, P.W., Carlson, E.J., Gillespie, A.M., Epstein, C.J., Basbaum, A.I. Nature (1998) [Pubmed]
  17. Substance P and cholecystokinin-like peptides in Helix neurons and cholecystokinin and serotonin in a giant neuron. Osborne, N.N., Cuello, A.C., Dockray, G.J. Science (1982) [Pubmed]
  18. Dual actions of substance P on nociception: possible role of endogenous opioids. Frederickson, R.C., Burgis, V., Harrell, C.E., Edwards, J.D. Science (1978) [Pubmed]
  19. Capsaicin and the cause of causalgia. Shuster, S. Lancet (1995) [Pubmed]
  20. Fast and slow synaptic potentials produced in a mammalian sympathetic ganglion by colon distension. Peters, S., Kreulen, D.L. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  21. Specific binding of 3H-substance P to rat brain membranes. Hanley, M.R., Sandberg, B.E., Lee, C.M., Iversen, L.L., Brundish, D.E., Wade, R. Nature (1980) [Pubmed]
  22. The role of endogenous nerve growth factor in human diabetic neuropathy. Anand, P., Terenghi, G., Warner, G., Kopelman, P., Williams-Chestnut, R.E., Sinicropi, D.V. Nat. Med. (1996) [Pubmed]
  23. Correlation between inositol phospholipid hydrolysis and substance P receptors in rat CNS. Mantyh, P.W., Pinnock, R.D., Downes, C.P., Goedert, M., Hunt, S.P. Nature (1984) [Pubmed]
  24. Lack of neurotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents. Ernfors, P., Lee, K.F., Kucera, J., Jaenisch, R. Cell (1994) [Pubmed]
  25. Intrathecal morphine inhibits substance P release from mammalian spinal cord in vivo. Yaksh, T.L., Jessell, T.M., Gamse, R., Mudge, A.W., Leeman, S.E. Nature (1980) [Pubmed]
  26. Substance P regulates the vasodilator activity of calcitonin gene-related peptide. Brain, S.D., Williams, T.J. Nature (1988) [Pubmed]
  27. Endothelium-dependent relaxation of coronary arteries by noradrenaline and serotonin. Cocks, T.M., Angus, J.A. Nature (1983) [Pubmed]
  28. Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid. Beal, M.F., Kowall, N.W., Ellison, D.W., Mazurek, M.F., Swartz, K.J., Martin, J.B. Nature (1986) [Pubmed]
  29. Stimulation of connective tissue cell growth by substance P and substance K. Nilsson, J., von Euler, A.M., Dalsgaard, C.J. Nature (1985) [Pubmed]
  30. Different binding epitopes on the NK1 receptor for substance P and non-peptide antagonist. Gether, U., Johansen, T.E., Snider, R.M., Lowe, J.A., Nakanishi, S., Schwartz, T.W. Nature (1993) [Pubmed]
  31. Reduced antinociception and plasma extravasation in mice lacking a neuropeptide Y receptor. Naveilhan, P., Hassani, H., Lucas, G., Blakeman, K.H., Hao, J.X., Xu, X.J., Wiesenfeld-Hallin, Z., Thorén, P., Ernfors, P. Nature (2001) [Pubmed]
  32. Peptide receptors as molecular targets for cancer diagnosis and therapy. Reubi, J.C. Endocr. Rev. (2003) [Pubmed]
  33. Hemokinin is a hematopoietic-specific tachykinin that regulates B lymphopoiesis. Zhang, Y., Lu, L., Furlonger, C., Wu, G.E., Paige, C.J. Nat. Immunol. (2000) [Pubmed]
  34. Localisation of substance P immunoreactivity in amacrine cells of the retina. Karten, H.J., Brecha, N. Nature (1980) [Pubmed]
  35. Substance P in principal sympathetic neurons: regulation by impulse activity. Kessler, J.A., Adler, J.E., Bohn, M.C., Black, I.B. Science (1981) [Pubmed]
  36. Substance P activity in the bullfrog retina: localization and identification in several vertebrate species. Eskay, R.L., Furness, J.F., Long, R.T. Science (1981) [Pubmed]
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