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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Knee Joint

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Disease relevance of Knee Joint


Psychiatry related information on Knee Joint


High impact information on Knee Joint

  • Two opposite responses were observed; while arthritis in TNF-alpha transgenic mice was not affected by inactivation of the IL-6 gene, DBA/1J, IL-6(-/-) mice were completely protected from CIA, accompanied by a reduced antibody response to type II collagen and the absence of inflammatory cells and tissue damage in knee joints [8].
  • No difference was noted in the course of CIA in the injected knee joints between Ad5E1mIL-4 and the control vector, but radiographic analysis revealed impressive reduction of joint erosion and more compact bone structure in the Ad5E1mIL-4 group [9].
  • These cationic proteins, all having an isoelectric point greater than 8.5 exhibited excellent retention in articular structures when injected in mouse knee joints [10].
  • Technetium-99m-pyrophosphate scintigraphy of knee joints in hyperparathyroidism [11].
  • After the injection of human IL-32gamma into the knee joints of naïve mice, joint swelling, with pronounced influx of inflammatory cells and cartilage damage, was observed [12].

Chemical compound and disease context of Knee Joint


Biological context of Knee Joint

  • METHODS: Northern blot analysis of total RNA extracted from the knee joints of transgenic Del1 mice, which harbor a short deletion in a type II collagen transgene, and of their nontransgenic littermates was used to monitor changes in COMP messenger RNA (mRNA) levels during cartilage degeneration [18].
  • METHODS: (125)I-labeled bFGF contained in gelatin hydrogel microspheres was administered to the knee joints of normal rabbits to confirm the sustained-release kinetics of bFGF in the knee joint [19].
  • 4. One week after surgical interruption of the nerve supply to the knee joint, co-administration of FK888 and SR48968 (both at 10(-8) mol) now produced slight vasodilatation (6.7 +/- 4.6%; n = 9) which did not differ significantly from vehicle treatment [20].
  • MATERIALS AND METHODS: We screened a cDNA library generated from unselected cells from the knee joint of a 62-year-old white female with long-standing RA [21].
  • OBJECTIVE: To assess the variability of synovial histology, immunohistology, and cytokine mRNA expression at different sites within the knee joints of subjects with rheumatoid arthritis receiving slow acting antirheumatic drugs [22].

Anatomical context of Knee Joint


Associations of Knee Joint with chemical compounds

  • We assessed the contribution of ATP and adenosine (i) to a major sign of acute inflammation, plasma extravasation (PE), in the rat knee joint and (ii) to the severity of joint injury in adjuvant-induced experimental arthritis, a chronic inflammatory disease [28].
  • Immunoreactive staining for substance P (SP), calcitonin gene-related peptide (CGRP) and glutamate (Glu) in the monkey dorsal horn was examined following inflammation of one knee joint induced by injection of 5% kaolin and 5% carrageenan [29].
  • Knee joint sections were examined for inflammation, cartilage degradation, and loss of glycosaminoglycans (by Safranin O staining) [30].
  • OBJECTIVE: To determine whether peripheral administration of the endogenous mu-opioid peptide endomorphin 1 could reduce knee joint pain, using animal models of acute and chronic arthritis [31].
  • RESULTS: MSU crystals produced a knee joint inflammation that was time dependent and was characterized by cell influx and cytokine release that was sensitive to treatment with classic anti-arthritic drugs (indomethacin, colchicine, dexamethasone) [32].

Gene context of Knee Joint

  • We conclude that Shh function is required for limb development distal to the elbow/knee joints, similar to the Shh(-/-) mouse [33].
  • METHODS: SF was drawn from the knee joints of patients with RA (n = 31) or OA (n = 31) [34].
  • In addition, knee joints of naive mice were injected intraarticularly with IL-4 and IL-10 alone or were coinjected with IL-1 [35].
  • In a previous study we found that if a chronic T-cell-mediated antigen-induced arthritis (AIA) was elicited in knee joints of FcR gamma-chain-deficient mice that lack functional Fc gamma RI and Fc gamma RIII, joint inflammation was comparable but severe cartilage destruction was absent [36].
  • Adenoviral transfer of murine oncostatin M elicits periosteal bone apposition in knee joints of mice, despite synovial inflammation and up-regulated expression of interleukin-6 and receptor activator of nuclear factor-kappa B ligand [37].

Analytical, diagnostic and therapeutic context of Knee Joint


  1. Effects of dehydroepiandrosterone on articular cartilage during the development of osteoarthritis. Jo, H., Ahn, H.J., Kim, E.M., Kim, H.J., Seong, S.C., Lee, I., Lee, M.C. Arthritis Rheum. (2004) [Pubmed]
  2. Synovial permeability in rheumatoid arthritis. Simkin, P.A. Arthritis Rheum. (1979) [Pubmed]
  3. Hemarthrosis associated with sodium warfarin therapy. Wild, J.H., Zvaifler, N.J. Arthritis Rheum. (1976) [Pubmed]
  4. The features of arthritis induced by CpG motifs in bacterial DNA. Deng, G.M., Tarkowski, A. Arthritis Rheum. (2000) [Pubmed]
  5. In vivo direct gene transfer into articular cartilage by intraarticular injection mediated by HVJ (Sendai virus) and liposomes. Tomita, T., Hashimoto, H., Tomita, N., Morishita, R., Lee, S.B., Hayashida, K., Nakamura, N., Yonenobu, K., Kaneda, Y., Ochi, T. Arthritis Rheum. (1997) [Pubmed]
  6. Effect of a neoprene sleeve on knee joint kinesthesis: influence of different testing procedures. Birmingham, T.B., Inglis, J.T., Kramer, J.F., Vandervoort, A.A. Medicine and science in sports and exercise. (2000) [Pubmed]
  7. Effects of short-term cycling on knee joint proprioception in ACL-deficient patients. Roberts, D., Ageberg, E., Andersson, G., Fridén, T. Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA. (2004) [Pubmed]
  8. Interleukin 6 is required for the development of collagen-induced arthritis. Alonzi, T., Fattori, E., Lazzaro, D., Costa, P., Probert, L., Kollias, G., De Benedetti, F., Poli, V., Ciliberto, G. J. Exp. Med. (1998) [Pubmed]
  9. IL-4 gene therapy for collagen arthritis suppresses synovial IL-17 and osteoprotegerin ligand and prevents bone erosion. Lubberts, E., Joosten, L.A., Chabaud, M., van Den Bersselaar, L., Oppers, B., Coenen-De Roo, C.J., Richards, C.D., Miossec, P., van Den Berg, W.B. J. Clin. Invest. (2000) [Pubmed]
  10. Cationization of catalase, peroxidase, and superoxide dismutase. Effect of improved intraarticular retention on experimental arthritis in mice. Schalkwijk, J., van den Berg, W.B., van de Putte, L.B., Joosten, L.A., van den Bersselaar, L. J. Clin. Invest. (1985) [Pubmed]
  11. Technetium-99m-pyrophosphate scintigraphy of knee joints in hyperparathyroidism. Lessem, J., Nosslin, B., Tibblin, S. Lancet (1977) [Pubmed]
  12. IL-32, a proinflammatory cytokine in rheumatoid arthritis. Joosten, L.A., Netea, M.G., Kim, S.H., Yoon, D.Y., Oppers-Walgreen, B., Radstake, T.R., Barrera, P., van de Loo, F.A., Dinarello, C.A., van den Berg, W.B. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  13. Efficacy and safety of nabumetone in 5,421 patients with osteoarthritis of the hip and/or knee joints. A subgroup evaluation of an outpatient study involving 18,047 patients. Fedder, M., Stroehmann, I. Drugs (1990) [Pubmed]
  14. Use of technetium-99m methylene diphosphonate and gallium-67 citrate scans after intraarticular injection of Staphylococcus aureus into knee joints of rabbits with chronic antigen-induced arthritis. Mahowald, M.L., Raskind, J.R., Peterson, L., Gerding, D., Raddatz, D.A., Shafer, R. J. Infect. Dis. (1986) [Pubmed]
  15. Factor IX thrombogenicity: in vivo effects on coagulation activation and a case report of disseminated intravascular coagulation. Small, M., Lowe, G.D., Douglas, J.T., Forbes, C.D., Prentice, C.R. Thromb. Haemost. (1982) [Pubmed]
  16. Chondrotoxicity and toxicokinetics of sparfloxacin in juvenile rats. Stahlmann, R., Zippel, U., Förster, C., Schwabe, R., Shakibaei, M., Merker, H.J., Borner, K. Antimicrob. Agents Chemother. (1998) [Pubmed]
  17. Nicotinic cholinergic receptors: potential targets for inflammatory pain relief. Lawand, N.B., Lu, Y., Westlund, K.N. Pain (1999) [Pubmed]
  18. Up-regulation of cartilage oligomeric matrix protein at the onset of articular cartilage degeneration in a transgenic mouse model of osteoarthritis. Salminen, H., Perälä, M., Lorenzo, P., Saxne, T., Heinegård, D., Säämänen, A.M., Vuorio, E. Arthritis Rheum. (2000) [Pubmed]
  19. The therapeutic effects of basic fibroblast growth factor contained in gelatin hydrogel microspheres on experimental osteoarthritis in the rabbit knee. Inoue, A., Takahashi, K.A., Arai, Y., Tonomura, H., Sakao, K., Saito, M., Fujioka, M., Fujiwara, H., Tabata, Y., Kubo, T. Arthritis Rheum. (2006) [Pubmed]
  20. Tachykinin regulation of basal synovial blood flow. Ferrell, W.R., Lockhart, J.C., Karimian, S.M. Br. J. Pharmacol. (1997) [Pubmed]
  21. Clonally-related immunoglobulin VH domains and nonrandom use of DH gene segments in rheumatoid arthritis synovium. Clausen, B.E., Bridges, S.L., Lavelle, J.C., Fowler, P.G., Gay, S., Koopman, W.J., Schroeder, H.W. Mol. Med. (1998) [Pubmed]
  22. Intraarticular variability of synovial membrane histology, immunohistology, and cytokine mRNA expression in patients with rheumatoid arthritis. Kirkham, B., Portek, I., Lee, C.S., Stavros, B., Lenarczyk, A., Lassere, M., Edmonds, J. J. Rheumatol. (1999) [Pubmed]
  23. Synovial origins of Rice bodies in joint fluid. Cheung, H.S., Ryan, L.M., Kozin, F., McCarty, D.J. Arthritis Rheum. (1980) [Pubmed]
  24. Expression of Sox9 and type IIA procollagen during attempted repair of articular cartilage damage in a transgenic mouse model of osteoarthritis. Salminen, H., Vuorio, E., Säämänen, A.M. Arthritis Rheum. (2001) [Pubmed]
  25. In vivo role of phagocytic synovial lining cells in onset of experimental arthritis. Van Lent, P.L., Van den Hoek, A.E., Van den Bersselaar, L.A., Spanjaards, M.F., Van Rooijen, N., Dijkstra, C.D., Van de Putte, L.B., Van den Berg, W.B. Am. J. Pathol. (1993) [Pubmed]
  26. Development of osteoarthritic lesions in mice by "metabolic" and "mechanical" alterations in the knee joints. van der Kraan, P.M., Vitters, E.L., van de Putte, L.B., van den Berg, W.B. Am. J. Pathol. (1989) [Pubmed]
  27. Adenovirus-mediated gene transfer of insulin-like growth factor 1 stimulates proteoglycan synthesis in rabbit joints. Mi, Z., Ghivizzani, S.C., Lechman, E.R., Jaffurs, D., Glorioso, J.C., Evans, C.H., Robbins, P.D. Arthritis Rheum. (2000) [Pubmed]
  28. Purinergic regulation of bradykinin-induced plasma extravasation and adjuvant-induced arthritis in the rat. Green, P.G., Basbaum, A.I., Helms, C., Levine, J.D. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  29. Neural changes in acute arthritis in monkeys. III. Changes in substance P, calcitonin gene-related peptide and glutamate in the dorsal horn of the spinal cord. Sluka, K.A., Dougherty, P.M., Sorkin, L.S., Willis, W.D., Westlund, K.N. Brain Res. Brain Res. Rev. (1992) [Pubmed]
  30. Accelerated, aging-dependent development of osteoarthritis in alpha1 integrin-deficient mice. Zemmyo, M., Meharra, E.J., Kühn, K., Creighton-Achermann, L., Lotz, M. Arthritis Rheum. (2003) [Pubmed]
  31. Chronic arthritis down-regulates peripheral mu-opioid receptor expression with concomitant loss of endomorphin 1 antinociception. Li, Z., Proud, D., Zhang, C., Wiehler, S., McDougall, J.J. Arthritis Rheum. (2005) [Pubmed]
  32. Activation of melanocortin type 3 receptor as a molecular mechanism for adrenocorticotropic hormone efficacy in gouty arthritis. Getting, S.J., Christian, H.C., Flower, R.J., Perretti, M. Arthritis Rheum. (2002) [Pubmed]
  33. The chick oligozeugodactyly (ozd) mutant lacks sonic hedgehog function in the limb. Ros, M.A., Dahn, R.D., Fernandez-Teran, M., Rashka, K., Caruccio, N.C., Hasso, S.M., Bitgood, J.J., Lancman, J.J., Fallon, J.F. Development (2003) [Pubmed]
  34. Synovial fluid levels of tumor necrosis factor alpha and oncostatin M correlate with levels of markers of the degradation of crosslinked collagen and cartilage aggrecan in rheumatoid arthritis but not in osteoarthritis. Manicourt, D.H., Poilvache, P., Van Egeren, A., Devogelaer, J.P., Lenz, M.E., Thonar, E.J. Arthritis Rheum. (2000) [Pubmed]
  35. Reduction of interleukin-17-induced inhibition of chondrocyte proteoglycan synthesis in intact murine articular cartilage by interleukin-4. Lubberts, E., Joosten, L.A., van de Loo, F.A., van den Gersselaar, L.A., van den Berg, W.B. Arthritis Rheum. (2000) [Pubmed]
  36. Role of activatory Fc gamma RI and Fc gamma RIII and inhibitory Fc gamma RII in inflammation and cartilage destruction during experimental antigen-induced arthritis. van Lent, P.L., Nabbe, K., Blom, A.B., Holthuysen, A.E., Sloetjes, A., van de Putte, L.B., Verbeek, S., van den Berg, W.B. Am. J. Pathol. (2001) [Pubmed]
  37. Adenoviral transfer of murine oncostatin M elicits periosteal bone apposition in knee joints of mice, despite synovial inflammation and up-regulated expression of interleukin-6 and receptor activator of nuclear factor-kappa B ligand. de Hooge, A.S., van de Loo, F.A., Bennink, M.B., de Jong, D.S., Arntz, O.J., Lubberts, E., Richards, C.D., vandDen Berg, W.B. Am. J. Pathol. (2002) [Pubmed]
  38. Transforming growth factor beta 1, a major stimulator of hyaluronan synthesis in human synovial lining cells. Haubeck, H.D., Kock, R., Fischer, D.C., Van de Leur, E., Hoffmeister, K., Greiling, H. Arthritis Rheum. (1995) [Pubmed]
  39. Synovial fluid analysis of two groups of proteoglycan epitopes distinguishes early and late cartilage lesions. Saxne, T., Heinegård, D. Arthritis Rheum. (1992) [Pubmed]
  40. Responses of blood vessels in the rabbit knee to electrical stimulation of the joint capsule. Ferrell, W.R., Khoshbaten, A. J. Physiol. (Lond.) (1990) [Pubmed]
  41. Analysis of the cell infiltrate and expression of matrix metalloproteinases and granzyme B in paired synovial biopsy specimens from the cartilage-pannus junction in patients with RA. Smeets, T.J., Kraan, M.C., Galjaard, S., Youssef, P.P., Smith, M.D., Tak, P.P. Ann. Rheum. Dis. (2001) [Pubmed]
  42. Calcitonin gene-related peptide increases blood flow and potentiates plasma protein extravasation in the rat knee joint. Cambridge, H., Brain, S.D. Br. J. Pharmacol. (1992) [Pubmed]
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