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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Different dopamine D1 and D2 receptors expression after motor activity in the striatal critical period.

Circling training during rat striatum postnatal critical period (PN30 to 37 days) induces a life-lasting co-reduction of muscarinic acetylcholine receptors (mAChR) and dopamine D2 receptors (D2R) binding. Here, we evaluated the expression of D1R and D2R under similar experimental conditions. Trained rats showed a decrease of 40% in D2R binding sites (p<0.01) and of 45% in the D2R mRNA expression which involve short (p<0.05) and long (p<0.01) isoforms. In contrast, D1R binding sites nor its mRNA expression levels were affected by training, indicating a differential synaptic refinement during this ontogenetically fixed period.[1]

References

  1. Different dopamine D1 and D2 receptors expression after motor activity in the striatal critical period. Soiza-Reilly, M., Fossati, M., Ibarra, G.R., Azcurra, J.M. Brain Res. (2004) [Pubmed]
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