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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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New cytotoxic steroids from the Indian Ocean sponge Axinella cf. bidderi.

Four new sterols have been isolated from the marine sponge Axinella cf. bidderi, 17alpha-hydroxy-22,23-epoxy-24-methylcholest-5-en-3beta-ol (1) and 17alpha-hydroxy-22,23-epoxycholest-5-en-3beta-ol (2), together with 3 and 4, which possess respectively the cholestene and the cholestane skeleton with a cyclic enol ether linkage between C-18 and C-22. The structures were elucidated using spectroscopic data. The in vitro activity was evaluated against prostate, ovary, pancreas, colon, and lung cell lines.[1]

References

  1. New cytotoxic steroids from the Indian Ocean sponge Axinella cf. bidderi. Funel, C., Berrué, F., Roussakis, C., Fernandez Rodriguez, R., Amade, P. J. Nat. Prod. (2004) [Pubmed]
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