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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

New cytotoxic steroids from the Indian Ocean sponge Axinella cf. bidderi.

Four new sterols have been isolated from the marine sponge Axinella cf. bidderi, 17alpha-hydroxy-22,23-epoxy-24-methylcholest-5-en-3beta-ol (1) and 17alpha-hydroxy-22,23-epoxycholest-5-en-3beta-ol (2), together with 3 and 4, which possess respectively the cholestene and the cholestane skeleton with a cyclic enol ether linkage between C-18 and C-22. The structures were elucidated using spectroscopic data. The in vitro activity was evaluated against prostate, ovary, pancreas, colon, and lung cell lines.[1]


  1. New cytotoxic steroids from the Indian Ocean sponge Axinella cf. bidderi. Funel, C., Berrué, F., Roussakis, C., Fernandez Rodriguez, R., Amade, P. J. Nat. Prod. (2004) [Pubmed]
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