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MeSH Review

Indian Ocean

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Disease relevance of Indian Ocean


Psychiatry related information on Indian Ocean


High impact information on Indian Ocean

  • During the last ice age, the Indian Ocean southwest monsoon exhibited abrupt changes that were closely correlated with millennial-scale climate events in the North Atlantic region, suggesting a mechanistic link [8].
  • Unexpectedly, under a similar regimen, pyridostigmine administration during the Persian Gulf War resulted in a greater than threefold increase in the frequency of reported central nervous system symptoms [9].
  • Two toxins, latrunculins A and B, which contain a new class of 16- and 14-membered marine macrolides attached to the rare 2-thiazolidinone moiety, were purified recently from the Red Sea sponge Latrunculia magnifica [10].
  • OBJECTIVE--To determine cause-specific mortality rates among US troops stationed in the Persian Gulf region and compare them with those of US troops serving elsewhere during Operations Desert Shield and Desert Storm [11].
  • Atropine poisoning in children during the Persian Gulf crisis. A national survey in Israel [12].

Chemical compound and disease context of Indian Ocean


Biological context of Indian Ocean


Anatomical context of Indian Ocean


Associations of Indian Ocean with chemical compounds

  • The simulations adopt the aerosol radiative forcing from the Indian Ocean experiment observations and also account for global increases in greenhouse gases and sulfate aerosols [25].
  • The title compound, 16-epi-latrunculin B (3), has been isolated from the sponge Negombata magnifica collected from the Red Sea near Hurghada, Egypt. This new natural product was determined to be an epimer of latrunculin B (1), which was found in the same sponge collection [26].
  • The authors determined plasma cortisol levels, platelet levels of mitochondrial benzodiazepine receptors, and anxiety and depression scores in 11 civilians exposed to the Persian Gulf war [27].
  • Increased 5-hydroxytryptamine and norepinephrine release from rat brain slices by the Red Sea flatfish toxin pardaxin [28].
  • We tested the hypothesis that pyridostigmine bromide (PB) intake and/or low-level sarin exposure, suggested by some as causes of the symptoms experienced by Persian Gulf War veterans, induce neurobehavioral dysfunction that outlasts their effects on cholinesterase [29].

Gene context of Indian Ocean

  • The deficient alleles of FUT1 and FUT6 have a very low incidence and they have been found mainly around the Indian Ocean [30].
  • Two distinct cDNAs corresponding to GSTA1 and GSTA2 genes encoding glutathione S-transferases (GSTs) from the hepatopancreas of red sea bream, Pagrus major were cloned and sequenced [31].
  • There have been reports linking lowered PON1 activity to physical symptoms after deployment to the Persian Gulf War (PGW) of 1990 to 1991 [32].
  • Marine-derived macrolides latrunculins A and B, of the Red Sea sponge Negombata magnifica, are the first marine natural products that have been found to reversibly bind to actin monomers and to disrupt its organization [33].
  • Exploiting the extensive oncologic experience with G-CSF, which demonstrated its safety and absence of serious side effects the authors developed a clinical protocol for use of this drug in potential mustard gas victims in the Persian Gulf conflict [34].

Analytical, diagnostic and therapeutic context of Indian Ocean


  1. Juvenile limb-girdle muscular dystrophy. Clinical, histopathological and genetic data from a small community living in the Reunion Island. Fardeau, M., Hillaire, D., Mignard, C., Feingold, N., Feingold, J., Mignard, D., de Ubeda, B., Collin, H., Tome, F.M., Richard, I., Beckmann, J. Brain (1996) [Pubmed]
  2. Knowledge, attitudes, and practices on hypertension in a country in epidemiological transition. Aubert, L., Bovet, P., Gervasoni, J.P., Rwebogora, A., Waeber, B., Paccaud, F. Hypertension (1998) [Pubmed]
  3. Mode of inhibition of HIV reverse transcriptase by 2-hexaprenylhydroquinone, a novel general inhibitor of RNA-and DNA-directed DNA polymerases. Loya, S., Rudi, A., Kashman, Y., Hizi, A. Biochem. J. (1997) [Pubmed]
  4. The impact of infectious diseases on the health of U.S. troops deployed to the Persian Gulf during operations Desert Shield and Desert Storm. Hyams, K.C., Hanson, K., Wignall, F.S., Escamilla, J., Oldfield, E.C. Clin. Infect. Dis. (1995) [Pubmed]
  5. Is systemic lupus erythematosus, amyotrophic lateral sclerosis, or fibromyalgia associated with Persian Gulf War service? An examination of Department of Defense hospitalization data. Smith, T.C., Gray, G.C., Knoke, J.D. Am. J. Epidemiol. (2000) [Pubmed]
  6. Genetic predisposition to adverse consequences of anti-cholinesterases in 'atypical' BCHE carriers. Loewenstein-Lichtenstein, Y., Schwarz, M., Glick, D., Nørgaard-Pedersen, B., Zakut, H., Soreq, H. Nat. Med. (1995) [Pubmed]
  7. Salivary cortisol and PTSD symptoms in Persian Gulf War combatants. Kellner, M., Baker, D.G., Yehuda, R. Ann. N. Y. Acad. Sci. (1997) [Pubmed]
  8. Abrupt changes in the Asian southwest monsoon during the Holocene and their links to the North Atlantic Ocean. Gupta, A.K., Anderson, D.M., Overpeck, J.T. Nature (2003) [Pubmed]
  9. Pyridostigmine brain penetration under stress enhances neuronal excitability and induces early immediate transcriptional response. Friedman, A., Kaufer, D., Shemer, J., Hendler, I., Soreq, H., Tur-Kaspa, I. Nat. Med. (1996) [Pubmed]
  10. Latrunculins: novel marine toxins that disrupt microfilament organization in cultured cells. Spector, I., Shochet, N.R., Kashman, Y., Groweiss, A. Science (1983) [Pubmed]
  11. Comparative mortality among US military personnel in the Persian Gulf region and worldwide during Operations Desert Shield and Desert Storm. Writer, J.V., DeFraites, R.F., Brundage, J.F. JAMA (1996) [Pubmed]
  12. Atropine poisoning in children during the Persian Gulf crisis. A national survey in Israel. Amitai, Y., Almog, S., Singer, R., Hammer, R., Bentur, Y., Danon, Y.L. JAMA (1992) [Pubmed]
  13. Peyssonols A and B, two novel inhibitors of the reverse transcriptases of human immunodeficiency virus types 1 and 2. Loya, S., Bakhanashvili, M., Kashman, Y., Hizi, A. Arch. Biochem. Biophys. (1995) [Pubmed]
  14. Effectiveness of a vaccine against red sea bream iridoviral disease in a field trial test. Nakajima, K., Maeno, Y., Honda, A., Yokoyama, K., Tooriyama, T., Manabe, S. Dis. Aquat. Org. (1999) [Pubmed]
  15. Kinetic analysis of cadmium toxicity to red sea bream, Pagrus major. Kuroshima, R., Kimura, S., Date, K., Yamamoto, Y. Ecotoxicol. Environ. Saf. (1993) [Pubmed]
  16. Cystic fibrosis in the population of Reunion Island. Hillaire, D., Chomel, J.C., Lesure, F., Renouil, M., Musenger, C., Pierson, F., Berthelon, M., Lenoir, G., Gérard, G., Bois, E. Ann. Genet. (1991) [Pubmed]
  17. Crystal structure of red sea bream transglutaminase. Noguchi, K., Ishikawa, K., Yokoyama Ki, n.u.l.l., Ohtsuka, T., Nio, N., Suzuki , E. J. Biol. Chem. (2001) [Pubmed]
  18. Dolastatin 11 connects two long-pitch strands in F-actin to stabilize microfilaments. Oda, T., Crane, Z.D., Dicus, C.W., Sufi, B.A., Bates, R.B. J. Mol. Biol. (2003) [Pubmed]
  19. Evaluation of sequence variation and selection in the bindin locus of the red sea urchin, Strongylocentrotus franciscanus. Debenham, P., Brzezinski, M.A., Foltz, K.R. J. Mol. Evol. (2000) [Pubmed]
  20. Phylogeography of the pantropical sea urchin Tripneustes: contrasting patterns of population structure between oceans. Lessios, H.A., Kane, J., Robertson, D.R. Evolution (2003) [Pubmed]
  21. The acid-stable proteinase inhibitor of human mucous secretions (HUSI-I, antileukoprotease). Complete amino acid sequence as revealed by protein and cDNA sequencing and structural homology to whey proteins and Red Sea turtle proteinase inhibitor. Seemüller, U., Arnhold, M., Fritz, H., Wiedenmann, K., Machleidt, W., Heinzel, R., Appelhans, H., Gassen, H.G., Lottspeich, F. FEBS Lett. (1986) [Pubmed]
  22. Latrunculin A is a potent inhibitor of phagocytosis by macrophages. de Oliveira, C.A., Mantovani, B. Life Sci. (1988) [Pubmed]
  23. Effects of latrunculin A on immunological phagocytosis and macrophage spreading-associated changes in the F-actin/G-actin content of the cells. Oliveira, C.A., Kashman, Y., Mantovani, B. Chem. Biol. Interact. (1996) [Pubmed]
  24. A new class of glutathione S-transferase from the hepatopancreas of the red sea bream Pagrus major. Konishi, T., Kato, K., Araki, T., Shiraki, K., Takagi, M., Tamaru, Y. Biochem. J. (2005) [Pubmed]
  25. Atmospheric brown clouds: impacts on South Asian climate and hydrological cycle. Ramanathan, V., Chung, C., Kim, D., Bettge, T., Buja, L., Kiehl, J.T., Washington, W.M., Fu, Q., Sikka, D.R., Wild, M. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  26. Toward computing relative configurations: 16-epi-latrunculin B, a new stereoisomer of the actin polymerization inhibitor latrunculin B. Hoye, T.R., Ayyad, S.E., Eklov, B.M., Hashish, N.E., Shier, W.T., El-Sayed, K.A., Hamann, M.T. J. Am. Chem. Soc. (2002) [Pubmed]
  27. Alteration of platelet benzodiazepine receptors by stress of war. Weizman, R., Laor, N., Karp, L., Dagan, E., Reiss, A., Dar, D.E., Wolmer, L., Gavish, M. The American journal of psychiatry. (1994) [Pubmed]
  28. Increased 5-hydroxytryptamine and norepinephrine release from rat brain slices by the Red Sea flatfish toxin pardaxin. Wang, H.Y., Friedman, E. J. Neurochem. (1986) [Pubmed]
  29. Delayed neurologic and behavioral effects of subtoxic doses of cholinesterase inhibitors. Scremin, O.U., Shih, T.M., Huynh, L., Roch, M., Booth, R., Jenden, D.J. J. Pharmacol. Exp. Ther. (2003) [Pubmed]
  30. Molecular genetics of alpha-L-fucosyltransferase genes (H, Se, Le, FUT4, FUT5 and FUT6). Mollicone, R., Candelier, J.J., Reguigne, I., Couillin, P., Fletcher, A., Oriol, R. Transfusion clinique et biologique : journal de la Société française de transfusion sanguine. (1994) [Pubmed]
  31. Molecular cloning and characterization of alpha-class glutathione S-transferase genes from the hepatopancreas of red sea bream, Pagrus major. Konishi, T., Kato, K., Araki, T., Shiraki, K., Takagi, M., Tamaru, Y. Comp. Biochem. Physiol. C Toxicol. Pharmacol. (2005) [Pubmed]
  32. Paraoxonase in Persian Gulf War veterans. Hotopf, M., Mackness, M.I., Nikolaou, V., Collier, D.A., Curtis, C., David, A., Durrington, P., Hull, L., Ismail, K., Peakman, M., Unwin, C., Wessely, S., Mackness, B. J. Occup. Environ. Med. (2003) [Pubmed]
  33. Bioactive natural and semisynthetic latrunculins. El Sayed, K.A., Youssef, D.T., Marchetti, D. J. Nat. Prod. (2006) [Pubmed]
  34. Granulocyte colony stimulating factor (G-CSF) for mustard-induced bone marrow suppression. Meisenberg, B.R., Melaragno, A.J., Monroy, R.L. Military medicine. (1993) [Pubmed]
  35. Arthroscopic surgery of the knee: its role in the support of U.S. troops during Operation Desert Shield on USNS mercy. Buckley, S.L., Alexander, A., Jones, M., Culp, R.W., Smallman, T. Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association. (1992) [Pubmed]
  36. Comparative morphology and cytology of the olfactory organs in Moray eels with remarks on their foraging behavior. Fishelson, L. Anat. Rec. (1995) [Pubmed]
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