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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

CD30(+) cutaneous lymphoma in association with atopic eczema.

BACKGROUND: Chronic atopic eczema is not regarded as a precursor of malignancy, and, to our knowledge, there has been only one previous case report of CD30(+) cutaneous lymphoma in association with atopic dermatitis. OBSERVATIONS: We report 4 cases of CD30(+) lymphoproliferative disease in young adult patients with active atopic eczema dating from early childhood. Three patients developed primary cutaneous anaplastic large cell lymphoma, of whom 2 developed systemic disease and 1 died. The other patient developed lymphomatoid papulosis type A, which resolved after withdrawal of cyclosporine therapy. No other patient had received immunosuppressive therapy. Three had been treated with phototherapy, and 2 of these patients exhibited positive immunostaining for p53 within a proportion of the tumor cell population. CONCLUSIONS: Although we have not been able to establish a causative link, we believe that the association of these 2 conditions has not occurred by chance. Biopsies of lesional skin from subjects with atopic eczema exhibit a proportion of CD30 cells, and clonal transformation of this subpopulation might account for the CD30(+) lymphomas in our patients.[1]


  1. CD30(+) cutaneous lymphoma in association with atopic eczema. Fletcher, C.L., Orchard, G.E., Hubbard, V., Whittaker, S.J., Edelson, R.L., Russell-Jones, R. Archives of dermatology. (2004) [Pubmed]
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