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MeSH Review

Lymphomatoid Papulosis

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Disease relevance of Lymphomatoid Papulosis


High impact information on Lymphomatoid Papulosis


Chemical compound and disease context of Lymphomatoid Papulosis


Anatomical context of Lymphomatoid Papulosis

  • In cutaneous lymphomatoid papulosis lesions a similar immunologic profile of the atypical cells was found; that is, they were positive for CD30, CD2, CD3, and CD25 but negative for B cell and macrophage antigens [15].
  • Furthermore, the large atypical cells of lymphomatoid papulosis also expressed other antigens (for example, T3, T4, HLA-DR, IL-2 receptors) that have previously been demonstrated on Reed-Sternberg cells [16].

Gene context of Lymphomatoid Papulosis

  • Our study attempts to evaluate the expression pattern of CD44 and CD44v6 in primary cutaneous CD30 positive T-cell lymphoproliferative disorders including primary cutaneous anaplastic large cell lymphoma (cALCL) and lymphomatoid papulosis (LyP) and compared the expression between these two subgroups [17].
  • Five of them occurred in human immunodeficiency virus-infected individuals, suggesting a possible interaction between p53 and viral proteins. p53 immunoreactivity was found over Reed-Sternberg-like cells in two cases of lymphomatoid papulosis [18].
  • Large atypical cells of lymphomatoid papulosis are CD56-negative: a study of 18 cases [19].
  • CONCLUSIONS: The current results indicate that the treatment with IFN-alpha of patients with lymphomatoid papulosis alters the clinical course of the disease with fewer side effects than previous regimens; however, short term treatment does not induce stable remission [20].
  • Although nodal ALCL, primary cutaneous ALCL, and lymphomatoid papulosis type A (lyp A) have similar histologic and immunohistochemical features, the expression of p80 in these cutaneous lesions has not been extensively studied [21].

Analytical, diagnostic and therapeutic context of Lymphomatoid Papulosis


  1. Acyclovir in lymphomatoid papulosis and mycosis fungoides. Burg, G., Klepzig, K., Kaudewitz, P., Wolf, H., Braun-Falco, O. JAMA (1986) [Pubmed]
  2. CD30-CD30 ligand interaction in primary cutaneous CD30(+) T-cell lymphomas: A clue to the pathophysiology of clinical regression. Mori, M., Manuelli, C., Pimpinelli, N., Mavilia, C., Maggi, E., Santucci, M., Bianchi, B., Cappugi, P., Giannotti, B., Kadin, M.E. Blood (1999) [Pubmed]
  3. Expression of cytotoxic proteins by neoplastic T cells in mycosis fungoides increases with progression from plaque stage to tumor stage disease. Vermeer, M.H., Geelen, F.A., Kummer, J.A., Meijer, C.J., Willemze, R. Am. J. Pathol. (1999) [Pubmed]
  4. The monoclonal antibody ALK1 identifies a distinct morphological subtype of anaplastic large cell lymphoma associated with 2p23/ALK rearrangements. Pittaluga, S., Wlodarska, I., Pulford, K., Campo, E., Morris, S.W., Van den Berghe, H., De Wolf-Peeters, C. Am. J. Pathol. (1997) [Pubmed]
  5. Reversal of hypereosinophilic syndrome and lymphomatoid papulosis with mepolizumab and imatinib. Koury, M.J., Newman, J.H., Murray, J.J. Am. J. Med. (2003) [Pubmed]
  6. Amplification of genomic DNA demonstrates the presence of the t(2;5) (p23;q35) in anaplastic large cell lymphoma, but not in other non-Hodgkin's lymphomas, Hodgkin's disease, or lymphomatoid papulosis. Sarris, A.H., Luthra, R., Papadimitracopoulou, V., Waasdorp, M., Dimopoulos, M.A., McBride, J.A., Cabanillas, F., Duvic, M., Deisseroth, A., Morris, S.W., Pugh, W.C. Blood (1996) [Pubmed]
  7. Detection of t(2;5)(p23;q35) translocation by reverse transcriptase polymerase chain reaction and in situ hybridization in CD30-positive primary cutaneous lymphoma and lymphomatoid papulosis. Beylot-Barry, M., Lamant, L., Vergier, B., de Muret, A., Fraitag, S., Delord, B., Dubus, P., Vaillant, L., Delaunay, M., MacGrogan, G., Beylot, C., de Mascarel, A., Delsol, G., Merlio, J.P. Am. J. Pathol. (1996) [Pubmed]
  8. The cell infiltrate in lymphomatoid papulosis comprises a mixture of polyclonal large atypical cells (CD30-positive) and smaller monoclonal T cells (CD30-negative). Gellrich, S., Wernicke, M., Wilks, A., Lukowsky, A., Muche, J.M., Jasch, K.C., Audring, H., Mason, D., Sterry, W. J. Invest. Dermatol. (2004) [Pubmed]
  9. CD8+ lymphomatoid papulosis and its differential diagnosis. Magro, C.M., Crowson, A.N., Morrison, C., Merati, K., Porcu, P., Wright, E.D. Am. J. Clin. Pathol. (2006) [Pubmed]
  10. CD30(+) cutaneous lymphoma in association with atopic eczema. Fletcher, C.L., Orchard, G.E., Hubbard, V., Whittaker, S.J., Edelson, R.L., Russell-Jones, R. Archives of dermatology. (2004) [Pubmed]
  11. Topical carmustine therapy for lymphomatoid papulosis. Zackheim, H.S., Epstein, E.H., Crain, W.R. Archives of dermatology. (1985) [Pubmed]
  12. PUVA-induced lymphomatoid papulosis in a patient with mycosis fungoides. Wolf, P., Cerroni, L., Smolle, J., Kerl, H. J. Am. Acad. Dermatol. (1991) [Pubmed]
  13. Bexarotene is a new treatment option for lymphomatoid papulosis. Krathen, R.A., Ward, S., Duvic, M. Dermatology (Basel) (2003) [Pubmed]
  14. Lymphomatoid papulosis: successful weekly pulse superpotent topical corticosteroid therapy in three pediatric patients. Paul, M.A., Krowchuk, D.P., Hitchcock, M.G., Jorizzo, J.L. Pediatric dermatology. (1996) [Pubmed]
  15. Hodgkin's disease followed by lymphomatoid papulosis. Immunophenotypic evidence for a close relationship between lymphomatoid papulosis and Hodgkin's disease. Kaudewitz, P., Stein, H., Plewig, G., Schwarting, R., Gerdes, J., Burg, G., Kind, P., Eckert, F., Braun-Falco, O. J. Am. Acad. Dermatol. (1990) [Pubmed]
  16. Monoclonal antibody patterns in lymphomatoid papulosis. Kaudewitz, P., Burg, G., Stein, H., Klepzig, K., Mason, D.Y., Braun-Falco, O. Dermatologic clinics. (1985) [Pubmed]
  17. Expression of CD44 and CD44v6 in primary cutaneous CD30 positive T-cell lymphoproliferative disorders. Liang, X., Smoller, B.R., Golitz, L.E. J. Cutan. Pathol. (2002) [Pubmed]
  18. p53 oncoprotein expression in cutaneous lymphoproliferations. Beylot-Barry, M., Vergier, B., DeMascarel, A., Beylot, C., Merlio, J.P. Archives of dermatology. (1995) [Pubmed]
  19. Large atypical cells of lymphomatoid papulosis are CD56-negative: a study of 18 cases. Harvell, J., Vaseghi, M., Natkunam, Y., Kohler, S., Kim, Y. J. Cutan. Pathol. (2002) [Pubmed]
  20. Therapeutic use of interferon-alpha for lymphomatoid papulosis. Schmuth, M., Topar, G., Illersperger, B., Kowald, E., Fritsch, P.O., Sepp, N.T. Cancer (2000) [Pubmed]
  21. The t(2;5)-associated p80 NPM/ALK fusion protein in nodal and cutaneous CD30+ lymphoproliferative disorders. Su, L.D., Schnitzer, B., Ross, C.W., Vasef, M., Mori, S., Shiota, M., Mason, D.Y., Pulford, K., Headington, J.T., Singleton, T.P. J. Cutan. Pathol. (1997) [Pubmed]
  22. CD30-positive atypical lymphoid cells in common non-neoplastic cutaneous infiltrates rich in neutrophils and eosinophils. Cepeda, L.T., Pieretti, M., Chapman, S.F., Horenstein, M.G. Am. J. Surg. Pathol. (2003) [Pubmed]
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