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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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T-bet controls autoaggressive CD8 lymphocyte responses in type 1 diabetes.

The T-box transcription factor T-bet is known to control lineage commitment and interferon-gamma production by T helper 1 ( Th1) CD4 lymphocytes. We report here that T-bet is essential for development of CD8 lymphocyte-dependent autoimmune diabetes (type 1 diabetes [T1D]) in the rat insulin promoter-lymphocytic choriomeningitis virus (LCMV) transgenic model for virally induced T1D. In the absence of T-bet, autoaggressive (anti-LCMV) CD8 lymphocytes were reduced in number and produced less IFN-gamma, but increased IL-2 compared with controls. Further analysis showed that T-bet intrinsically controls the generation, but not apoptosis, maintenance, or secondary expansion of antiviral effector/memory CD8 lymphocytes. This observation points toward a therapeutic opportunity for the treatment of T1D and other autoimmune disorders.[1]

References

  1. T-bet controls autoaggressive CD8 lymphocyte responses in type 1 diabetes. Juedes, A.E., Rodrigo, E., Togher, L., Glimcher, L.H., von Herrath, M.G. J. Exp. Med. (2004) [Pubmed]
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