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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Immunofluorescence assay for serologic diagnosis of SARS.

We evaluated an indirect immunofluorescence assay based on virus-infected cells for detecting anti-severe acute respiratory syndrome-associated coronavirus (SARS-CoV) immunoglobulin (Ig) G antibody. All confirmed SARS cases demonstrated seroconversion or fourfold rise in IgG antibody titer; no control was positive. Sensitivity and specificity of this assay were both 100%. Immunofluorescence assay can ascertain the status of SARS-CoV infection.[1]


  1. Immunofluorescence assay for serologic diagnosis of SARS. Chan, P.K., Ng, K.C., Chan, R.C., Lam, R.K., Chow, V.C., Hui, M., Wu, A., Lee, N., Yap, F.H., Cheng, F.W., Sung, J.J., Tam, J.S. Emerging Infect. Dis. (2004) [Pubmed]
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