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Zhu, Y. et al.

Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cells.

Apoptosis in activated T cells in vivo requires the proapoptotic Bcl-2 family member Bim. We show here that, despite its ability to bind LC8, a component of the microtubule dynein motor complex, most of the Bim in both healthy and apoptotic T cells is associated with mitochondria, not microtubules. In healthy resting T cells Bim is bound to the antiapoptotic proteins Bcl-2 and Bcl-x(L). In activated T cells, levels of Bcl-2 fall, and Bim is associated more with Bcl-x(L) and less with Bcl-2. Our results indicate that, in T cells, Bim function is regulated by interaction with Bcl-2 family members on mitochondria rather than by sequestration to the microtubules.[1]

References

Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cells. Zhu, Y., Swanson, B.J., Wang, M., Hildeman, D.A., Schaefer, B.C., Liu, X., Suzuki, H., Mihara, K., Kappler, J., Marrack, P. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]

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