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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Environmental influence on testicular MAP kinase (ERK1) activity in the frog Rana esculenta.

Recent studies suggest a role for ERK1 in the regulation of spermatogonial proliferation. In this report the frog Rana esculenta, a seasonal breeder, was used as a model to study the possible effect on ERK1 of photoperiod and temperature. Adult male R. esculenta were subjected to several combinations of light and temperature at different times of the year to elucidate the regulation of ERK1 testicular activity in the spermatogonial proliferation by these environmental factors. Western blot analysis shows that under controlled experimental conditions an increase of temperature and photoperiod in November, characterized by a decrease in primary spermatogonial mitosis, induces ERK1 activity and spermatogonial proliferation, as confirmed using the proliferating cellular nuclear antigen (PCNA) as an early molecular marker. In contrast, a decrease in temperature and photoperiod in March, with an increase of primary spermatogonial mitosis, impairs ERK1 activity and spermatogonial proliferation. In conclusion, our data clearly show for the first time in a non-mammalian vertebrate that the temperature and the photoperiod exert a role in the spermatogonial proliferation via ERK1 activity.[1]


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