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Gene Review

MARCH1  -  membrane-associated ring finger (C3HC4) 1,...

Homo sapiens

Synonyms: E3 ubiquitin-protein ligase MARCH1, FLJ20668, MARCH-I, Membrane-associated RING finger protein 1, Membrane-associated RING-CH protein I, ...
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Disease relevance of MARCH1


Psychiatry related information on MARCH1

  • Of the 14,238 children born in 1963 and living in Warsaw, 96 percent were given the Raven's Progressive Matrices Test and an arithmetic and a vocabulary test in March to June of 1974 [6].
  • DESIGN, SETTING, AND SUBJECTS: Randomized, double-blind, placebo-controlled crossover trial conducted March to October 2000 at a US ambulatory-care referral center among 105 men with a mean (SD) age of 66 (9) years who had erectile dysfunction and known or highly suspected CAD [7].
  • MEASUREMENTS AND RESULTS: A surplus of March births and a fall-off in September births was found in narcolepsy relative to the general population [8].
  • OBJECTIVES: A March peak and a September trough in the birth pattern of narcolepsy patients with clear-cut cataplexy was recently reported [8].
  • This seasonal birth excess is also found in schizoaffective disorder (December-March), major depression (March-May), and autism (March) but not in other psychiatric conditions with the possible exceptions of eating disorders and antisocial personality disorder [9].

High impact information on MARCH1

  • A recent meeting at the Juan March Foundation in Madrid, Spain brought together plant biologists to discuss the characteristics of plant stem cells that are unique and those that are shared by stem cells from the animal kingdom [10].
  • The recent Juan March Foundation meeting on "Regulation and functional insights in cellular polarity" focused on cellular polarity in yeasts, Dictyostelium, epithelial cells, fibroblasts, and immune cells [11].
  • We evaluated all children who were born at 25 or fewer completed weeks of gestation in the United Kingdom and Ireland from March through December 1995 at the time when they reached a median age of 30 months [12].
  • PARTICIPANTS--A total of 5115 Orange County children between 12 and 72 months of age using EPSDT services from March through December 1992 [13].
  • The latest findings on the structure of chromatin, its organization in the nucleus, and its involvement in regulating gene expression were presented at a recent meeting at the Juan March Foundation in Madrid, Spain [14].

Chemical compound and disease context of MARCH1

  • In Year 5, on average, boreal cycles included initial testosterone elevations in mid-January (vs. mid-July in australs), parturition in early March (vs. early September in australs), and peak body weight in mid-July (vs. late January in australs) [15].
  • Because about half of pregnancies in the U.S. are unplanned, according to the March of Dimes, birth defect prevention includes a recommended daily dose of 400 micro g synthetic folic acid for women of childbearing age [16].
  • Eight Pseudomonas aeruginosa clinical strains that produce the clavulanic-acid-inhibited beta-lactamase GES-2 were isolated from patients of a South African hospital from March to July 2000 [17].
  • A NIH sponsored conference on the Adequacy of Dialysis in Monterey, California in March of 1974 was focused somewhat on the "middle molecule" theory of uremic toxicity, but contained a presentation by Sargent and Gotch on the possibilities of urea kinetic modeling [18].
  • In March of 1972, the Southwest Oncology Group initiated a Phase II study, No. 7200, utilizing methyl-CCNU in the treatment of patients with solid tumors and lymphomas [19].

Biological context of MARCH1

  • These sequences were found to correspond exactly with the amino acid sequence deduced from the IL-1-alpha cDNA reported by March et al [20].
  • Thus the double amplitude (total extent of variation) of the circadian rhythm in circulating total, T and T helper lymphocytes varied between 0 in March (P greater than 0.30; no rhythm) and up to 46-68% of the 24-h-mean (M) in November, with acrophases (times of maximum, 0) localized in the first half of the night (P less than 0.001) [21].
  • Internal medicine in the National Resident Matching Program 1987: the ides of March [22].
  • METHODS: From March to August 2003 we conducted a national survey of HIV prevalence and sexual behavior among 11 904 15-24 year olds [23].
  • The adjusted retention (retention fraction adjusted for total calcium intake, smoking status, and log years since menopause) was significantly higher in women evaluated in the months of August through October (mean +/- SD, 19.8 +/- 4.1%, n = 13) than in March through May (mean +/- SD, 17.0 +/- 4.7%, n = 18, p = 0.05) [24].

Anatomical context of MARCH1

  • A circannual rhythm was statistically validated by cosinor for total (0 in November), pan-T (0 in March), T suppressor-cytotoxic (0 in December), and NK lymphocytes (0 in October) [21].
  • METHODS: From March to June 2002, all chronically ischemic lower extremities that met standard indications for revascularization were prospectively enrolled and independently graded with the LEGS score by an "endovascular surgeon" and an "open surgeon" for comparative analysis [25].
  • RESULTS: From March to October 2003, 76 women were enrolled and 795 breast milk samples were collected from 60 women who were randomized and followed after delivery [26].
  • Although the aerosol samples were collected in March under wintry conditions, the organic carbon from fungal spores amounted to 2.9-5.4% of organic carbon in the "coarse mode" size fraction [27].
  • During the shortest day regime from December to March, when the birds peaked breeding, the number and size of DCVs and mitochondria increased, and Golgi body-endoplasmic reticulum-lysosome complex (GERL) was very well defined [28].

Associations of MARCH1 with chemical compounds

  • In Part I of this article (published in the March issue of TIBS1), substrate-binding and catalysis in lactate dehydrogenase were examined by genetic modification of the protein structure and analysis of the functional consequences [29].
  • The birds in which RA could be delineated in July had in March a higher activity of the HVC to area X projection as reflected by the total amount of Mn(2+) accumulated in area X, which suggests unexpected relationships between the two types of HVC projection neurons [30].
  • Seasonal rhythmicity in the incorporation of tritiated thymidine was exhibited by both lymphocyte subpopulations, with peak responses two to five times higher in March to April 1978 and February to March 1979 than during the previous two Decembers [31].
  • Oral glucose tolerance tests were performed in 12 young men in the Antarctic. Tests were done in the morning and afternoon at three monthly intervals (March, June, September, December) [32].
  • Predialysis blood urea nitrogen concentrations peaked in March, which coincided approximately with the peak protein catabolic rates, as well as protein and energy intakes (determined by dietary recall) [33].

Physical interactions of MARCH1


Other interactions of MARCH1

  • 1. In a group of ski-runners (A) significantly higher activities of CS, MDH, HOADH in the preparatory period (October) and also at the end of the competition period (March) were found in athletes with higher sports performance [35].
  • SETTING: General population of Hong Kong at the height of the SARS outbreak (29 March to 6 April 2003) [36].
  • In parallel, ERK1/2 (molecular weight 44 and 42 kDa, respectively) are highly phosphorylated during the period of active spermatogenesis and in post-refractory period (August) compared with the winter stasis (from November to March) [37].
  • METHODS: A retrospective chart review of 107 patients diagnosed with BPPV at our institution between March of 1993 and June of 1995 [38].
  • 4. Twenty I.U. of ACTH (given in March), elevated cortisol levels from 4-8 micrograms/dl (pretreatment) to 16-21 micrograms/dl (140 min post-administration) [39].

Analytical, diagnostic and therapeutic context of MARCH1

  • DESIGN, SETTING, AND PARTICIPANTS: Retrospective cohort study conducted from March to August 1999 among adults aged 20 to 34 years who, as infants, participated during 1965-1978 in controlled feeding studies conducted at the University of Iowa, Iowa City (248 were fed soy formula and 563 were fed cow milk formula during infancy) [40].
  • In March, when the patients were asymptomatic, the mean +/-SD of the Fc epsilon R+ lymphocytes did not significantly differ from the nonallergic control group: nonallergic Fc epsilon R+ 1.2 +/- 0.9% (29 +/- 20/,mm3), allergic Fc epsilon R+ 2.0 +/- 3.1% (48 +/- 52/mm3) [41].
  • OBJECTIVE: To examine the influence of environmental-structural factors in promoting consistent condom use (CCU) among female sex workers (FSW) and their regular paying partners in the Dominican Republic. METHODS: A cross-sectional survey was conducted with 288 FSW recruited from 41 sex establishments in Santo Domingo from March to June 1998 [42].
  • RTVIs were documented in 23% of hospitalizations and in 45% of patients admitted between December and March [43].
  • Case-control studies revealed that illness was significantly associated with eating foods from the university's main cafeteria deli bar on 9 and 10 March [44].


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