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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Emodin, a protein tyrosine kinase inhibitor from Polygonum cuspidatum.

Bioassay-directed fractionation of a Chinese medicinal plant, Polygonum cuspidatum (Polygonaceae), has led to the discovery of an anthraquinone, emodin [1], as a strong inhibitor of a protein tyrosine kinase (p56lck) partially purified from bovine thymus. Comparison of the IC50 values of emodin for protein tyrosine kinase inhibitory activity with physcion [2] and emodin-O8-D-glucoside [3], also isolated from the same plant, reveal the importance of the hydroxyl groups at C-6 and C-8 for the observed activity.[1]


  1. Emodin, a protein tyrosine kinase inhibitor from Polygonum cuspidatum. Jayasuriya, H., Koonchanok, N.M., Geahlen, R.L., McLaughlin, J.L., Chang, C.J. J. Nat. Prod. (1992) [Pubmed]
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