Disease relevance of Bis-alkylamino anthraquinone

• Breast tumor progenitor cells of 46 specimens were more sensitive than were bone marrow progenitors to the anthraquinone derivatives in 26 to 39% of instances, ratios which are similar to the clinically observed response rates of patients with breast carcinoma to these agents [1].
• In this study, beta-catenin mutations were identified in all 19 anthraquinone-induced hepatoblastomas and all 8 oxazepam-induced hepatoblastomas examined [2].
• Melanosis coli. A consequence of anthraquinone-induced apoptosis of colonic epithelial cells [3].
• In an attempt to study the relative toxicity of anthraquinonic laxatives on intestinal mucosa, we compared in mice the effects of fruit pulp containing sennosides A and B with those of a free anthraquinone, 1-8 dihydroxyanthraquinone [4].
• Electron microscopic examination of anthraquinone-treated herpes simplex virus demonstrated that the envelopes were partially disrupted [5].

Psychiatry related information on Bis-alkylamino anthraquinone

• BACKGROUND/AIM: To define the possible contribution of altered small intestinal motor activity to side-effects of bulking fibres, we sought to compare the relative effects of intraduodenal and intracolonic administration of the bulking fibre psyllium and the anthraquinone laxative senna on canine small intestinal motor activity [6].
• Opponent process theory (R. L. Solomon & J. D. Corbit, 1973, 1974) and adaptation-level theory (H. Helson, 1948) are alternative explanations of this stability that explain how environmental effects on job satisfaction dissipate across time [7].

High impact information on Bis-alkylamino anthraquinone

• Excessively high cell proliferation in sigmoid colon after an oral purge with anthraquinone glycosides [8].
• Clinical studies using mitoxantrone, an anthraquinone, were begun in the United States in 1979 [9].
• Linearized pUC19 plasmid was ligated to an oligomer containing a covalently linked anthraquinone group and six regularly spaced GG steps, which serve as traps for the migrating radical cation [10].
• An anthraquinone-linked duplex DNA oligomer containing 60 base pairs was synthesized by PCR [11].
• These redox modules were incorporated through solid-phase peptide synthesis into a 13-residue helical oligoproline assembly bearing in linear array a phenothiazine electron donor, a tris(bipyridine)ruthenium(II) chromophore, and an anthraquinone electron acceptor [12].

Chemical compound and disease context of Bis-alkylamino anthraquinone

• The kinetics of the charge recombination D+QA-----DQA was used to probe the protonation of the primary acceptor in reaction centers from Rhodopseudomonas sphaeroides, in which the native ubiquinone was replaced by anthraquinone [13].
• The effect of aloe emodin (AE), a herbal anthraquinone derivative, on the rat C6 glioma cell line was investigated [14].
• Emodin, a natural anthraquinone derivative isolated from Rheum palmatum L., has been reported to exhibit anti-cancer effect on several human cancers such as liver cancers and lung cancers [15].
• The mutagenicity of anthracene, anthraquinone, and four structurally similar compounds of each was evaluated in the Ames/Salmonella microsome assay [16].
• Structure of the photosynthetic reaction centre from Rhodobacter sphaeroides reconstituted with anthraquinone as primary quinone Q(A) [17].

Biological context of Bis-alkylamino anthraquinone

• Effects of 9,10-anthracenedione, 1,4-bis[(2-[(2-hydroxyethyl)amino]-ethyl)amino]-diacetate on cell survival and cell cycle progression in cultured mammalian cells [18].
• Recent studies of our group have shown that the oxidation of the substituted anthraquinone skeleton is involved in the biotransformation of mitoxantrone [19].
• With the help of theoretical calculations, we disclose some key features underlying the inhibitory efficiency of anthraquinone derivatives, outlining three different binding modes into the active site [20].
• In the series examined, the lowest distal/proximal DNA damage ratios are obtained with Ru and AQ, while, for both Rh and Et, high distal/proximal damage ratios are found [21].
• Anthraquinone-modified DNA assemblies of identical base composition but different base sequence are also probed [22].

Anatomical context of Bis-alkylamino anthraquinone

• Patterns of interaction between anthraquinone drugs and the calcium-release channel from cardiac sarcoplasmic reticulum [23].
• Abnormal function of the cardiac calcium-release channel will alter calcium handling within the myocyte and may be the basis for anthraquinone-related cardiotoxicity [23].
• Ultrastructure of mouse intestinal mucosa and changes observed after long term anthraquinone administration [4].
• We therefore attempted to test emodin and several other kinds of anthraquinone derivatives on EC/CUHK1, a cell line derived from esophageal carcinoma, and on a nude mouse model, with regard to their effects and mechanisms [24].
• Anthraquinone purgatives were found to increase the number of macrophages in the connective tissue of the colonic mucosa [25].

Associations of Bis-alkylamino anthraquinone with other chemical compounds

• Millimolar caffeine both inhibits anthraquinone-stimulated Ca2+ release, and reduces anthraquinone-stimulated [3H]ryanodine receptor occupancy, without changing the effective binding constant of the anthraquinone for its binding site [26].
• The 13-residue assembly formed a linear array containing a phenothiazine electron donor, a tris(bipyridine)ruthenium(II) chromophore, and an anthraquinone electron acceptor with the proline II secondary structure as shown by circular dichroism measurements [27].
• Its first stable biosynthetic precursor is the anthraquinone norsolorinic acid (compound 3. ), which accumulates in the Aspergillus mutant strain NOR-1 [28].
• The synthesized 2-methyl-substituted anthraquinone derivatives have first half-wave reduction potentials of -0.52 to -0.56 V at pH 7.0, which are the lowest oxidation-reduction potentials of quinone bioreductive alkylating agents synthesized by this laboratory to date [29].
• The unexpectedly large effect of the polar substitutions is not due to reorientation of the methoxy groups as similar redox potential changes are seen for these mutants with either ubiquinone or anthraquinone as Q(A) [30].

Gene context of Bis-alkylamino anthraquinone

• Activation of human telomerase reverse transcriptase expression by some new symmetrical bis-substituted derivatives of the anthraquinone [31].
• In this study, we found that emodin, an anthraquinone which has been isolated from the rhizome of Rheum palmatum, significantly inhibited TNF alpha-induced MMP-1 gene expression in a concentration-dependent manner [32].
• When excess 9,10-anthraquinone is added in vitro, it displaces PQ-9 and occupies the A1 binding site more readily than in the menB mutant [33].
• The present study details the effects on human telomerase of these new classes of 1,4- and 1,5-difunctionalized tricyclic anthraquinone compounds [34].
• Similarly, immunostaining to evaluate p53 protein may be useful to predict the response in patients treated with an anthraquinone drug [35].

Analytical, diagnostic and therapeutic context of Bis-alkylamino anthraquinone

• The receptor selectivity toward different anthraquinone derivatives 2 has been studied using 1H NMR spectroscopy, X-ray crystallography, UV spectroscopy, and isothermal microcalorimetry (ITC) [36].
• CONCLUSIONS: HPLC product analysis demonstrated that Iz is a key oxidation product of G through 8-oxoG in DNA photosensitized with riboflavin or anthraquinone [37].
• Influence of functional group substitutions on the carcinogenicity of anthraquinone in rats and mice: analysis of long-term bioassays by the National Cancer Institute and the National Toxicology Program [38].
• In addition, the role of the SR in ischemic preconditioning and in some instances of toxic myocardial injury (particularly, anthraquinone-induced injury) is discussed [39].
• Three of 13 patients treated with chemotherapy containing anthracycline/anthraquinone attained complete remission, in contrast to none of the eight who were treated with regimens without anthracycline [40].

References