RIP5 is a RIP-homologous inducer of cell death.
Members of the RIP serine/threonine kinase family are involved in activation of NF-kappaB, JNK, and p38, and induction of apoptosis. Here we report the identification of a novel RIP-homologous protein designated as RIP5. The C-terminus of RIP5 contains a kinase domain, which is mostly homologous with the kinase domain of RIP. RIP5 also contains a large unconserved N-terminal domain. Overexpression of RIP5 induces cell death with characteristic apoptotic morphology. Overexpression of RIP5 also induces DNA fragmentation and this is blocked by the caspase inhibitor crmA. However, RIP5-induced apoptotic morphology is not blocked by crmA. These findings suggest that RIP5 may induce both caspase-dependent apoptosis and caspase-independent cell death.[1]References
- RIP5 is a RIP-homologous inducer of cell death. Zha, J., Zhou, Q., Xu, L.G., Chen, D., Li, L., Zhai, Z., Shu, H.B. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
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