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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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MAP1B is required for Netrin 1 signaling in neuronal migration and axonal guidance.

BACKGROUND: The signaling cascades governing neuronal migration and axonal guidance link extracellular signals to cytoskeletal components. MAP1B is a neuron-specific microtubule-associated protein implicated in the crosstalk between microtubules and actin filaments. RESULTS: Here we show that Netrin 1 regulates, both in vivo and in vitro, mode I MAP1B phosphorylation, which controls MAP1B activity, in a signaling pathway that depends essentially on the kinases GSK3 and CDK5. We also show that map1B-deficient neurons from the lower rhombic lip and other brain regions have reduced chemoattractive responses to Netrin 1 in vitro. Furthermore, map1B mutant mice have severe abnormalities, similar to those described in netrin 1-deficient mice, in axonal tracts and in the pontine nuclei. CONCLUSIONS: These data indicate that MAP1B phosphorylation is controlled by Netrin 1 and that the lack of MAP1B impairs Netrin 1-mediated chemoattraction in vitro and in vivo. Thus, MAP1B may be a downstream effector in the Netrin 1-signaling pathway.[1]

References

  1. MAP1B is required for Netrin 1 signaling in neuronal migration and axonal guidance. Del Río, J.A., González-Billault, C., Ureña, J.M., Jiménez, E.M., Barallobre, M.J., Pascual, M., Pujadas, L., Simó, S., La Torre, A., Wandosell, F., Avila, J., Soriano, E. Curr. Biol. (2004) [Pubmed]
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