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Shihabi, Z.K.

Shihabi,

Fenofibrate and fenofibric acid analysis by capillary electrophoresis.

A capillary electrophoresis method has been developed to measure fenofibrate in capsules based on micellar electrokinetic capillary chromatography with detection at 280 nm using a borate buffer containing sodium dodecyl sulfate (SDS). However, the metabolite of this drug (fenofibric acid) in serum and whole blood was analyzed by capillary zone electrophoresis (CZE) in a borate-carbonate buffer using acetonitrile stacking. The analysis is rapid, < 7 min with no interferences. Incubation of fenofibrate in whole blood caused hydrolysis of the ester bond with the release of fenofibric acid.[1]

References

Fenofibrate and fenofibric acid analysis by capillary electrophoresis. Shihabi, Z.K. Electrophoresis (2004) [Pubmed]

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