- Stimulation of insulin-like growth factor (IGF) binding protein-3 synthesis by IGF-I and transforming growth factor-alpha is mediated by both phosphatidylinositol-3 kinase and mitogen-activated protein kinase pathways in mammary epithelial cells. Sivaprasad, U., Fleming, J., Verma, P.S., Hogan, K.A., Desury, G., Cohick, W.S. Endocrinology (2004)