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Gene Review

IGFBP1  -  insulin-like growth factor binding protein 1

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Disease relevance of IGFBP1


High impact information on IGFBP1


Biological context of IGFBP1


Anatomical context of IGFBP1

  • Perfused IGFBP1, 2, 3, and IGF-I also crossed the capillary boundary but in contrast to IGFBP4, preferentially localized in cardiac muscle with a connective tissue/muscle ratio of approximately 1:3 [15].
  • As in the isolated heart, the IGFBP-1 preferentially localized to cardiac muscle with a connective tissue:cardiac muscle ratio of 1:3 [16].
  • Profiles of IGFBP activity were similar in follicular fluid of small, medium, and E-I large follicles [10].
  • Profiles of IGFBP activity in homogenates of granulosa or theca cells were similar to follicular fluid profiles except for the absence of IGFBP-3 binding activity [10].
  • Tissue specificity and changes in abundance of IGFBPs in the uterus during early conceptus elongation indicate the potential importance of IGFBP regulation of uterine IGFs during this time period [17].

Associations of IGFBP1 with chemical compounds

  • Intensities of the 34-kDa (IGFBP-2), 29-27-kDa, and 22-kDa IGFBP bands in follicular fluid were nondetectable or were lower (p < 0.01) in the fluid of large (> or = 8 mm) E-active (E-A; E2 > 50 ng/ml and > P4) follicles than in large E-inactive (E-I), medium (5-7 mm), or small (< 5 mm) follicles [10].
  • These results suggest that the downstream effects of mechanical strain on IGF-I and IGFBP transcript levels are mediated, to greater or lesser extent, either through an angiotensin II tranducing pathway or via a feedback loop involving the autocrine secretion of IGF-I itself [18].
  • The objectives of this study were to provide insight into the magnitude of variation in follicular fluid concentrations of steroids and activities of IGFBP that exists among individual small antral follicles within and between cows, and to determine the relationships between follicular fluid IGFBP and steroid concentrations in these follicles [19].
  • Concentrations of E2 were correlated negatively with each IGFBP (r = -0.4 to -0.8; P < 0.05) except IGFBP-3 [19].
  • In addition, the differential regulation of IGFBP-2, -3 and -6 by retinoic acid (which inhibits proliferation) and IGF-I (which stimulates proliferation) suggests that these forms of IGFBP have different roles in regulating mammary epithelial cell physiology [20].

Regulatory relationships of IGFBP1

  • In contrast, the expression for IGFBP-1 was upregulated in the mammary gland of virgin heifers and increased around the onset of lactation. mRNA for GHR was found during all stages examined without outstanding fluctuations [21].

Other interactions of IGFBP1

  • As IGFs are secreted in large amounts by the female reproductive tract, it has been hypothesized that maternal IGFs may affect embryonic growth and differentiation in a fine-tuned manner, involving modulation of IGF effects by embryonic IGFBP and IGF-I-R expression [22].
  • IGFBP-4 was the predominant IGFBP expressed by both cell types and did not change with exposure to hypoxia [1].
  • Pregnancy-associated plasma protein-A and insulin-like growth factor binding protein mRNAs in granulosa cells of dominant and subordinate follicles of preovulatory cattle [23].
  • Individual total ligand (IGF-I + IGF-II) concentration and IGFBP pattern prepartum were largely regained 5 days post-partum in all cows [24].
  • In this study we have investigated effects of delayed colostrum intake in neonatal calves on metabolic traits and on IGF-I, IGF binding proteins (IGFBP), growth hormone (GH), and insulin concentrations in plasma [25].

Analytical, diagnostic and therapeutic context of IGFBP1


  1. Modulation of insulin-like growth factor (IGF) and IGF binding protein biosynthesis by hypoxia in cultured vascular endothelial cells. Tucci, M., Nygard, K., Tanswell, B.V., Farber, H.W., Hill, D.J., Han, V.K. J. Endocrinol. (1998) [Pubmed]
  2. Effect of an insulin-like growth factor binding protein fusion protein on thymidine incorporation in neuroblastoma and rhabdomyosarcoma cell lines. Dake, B.L., Boes, M., Bach, L.A., Bar, R.S. Endocrinology (2004) [Pubmed]
  3. Increased expression of insulin-like growth factor binding protein-1 during induced regression of bovine corpora lutea. Sayre, B.L., Taft, R., Inskeep, E.K., Killefer, J. Biol. Reprod. (2000) [Pubmed]
  4. Evaluation of serum insulin-like growth factor binding proteins (IGFBP) in Angus cattle divergently selected for serum IGF-I concentration. Pagan, M., Davis, M.E., Stick, D.A., Simmen, R.C., Raney, N.E., Tempelman, R.J., Ernst, C.W. Domest. Anim. Endocrinol. (2003) [Pubmed]
  5. A novel putative low-affinity insulin-like growth factor-binding protein, LIBC (lost in inflammatory breast cancer), and RhoC GTPase correlate with the inflammatory breast cancer phenotype. van Golen, K.L., Davies, S., Wu, Z.F., Wang, Y., Bucana, C.D., Root, H., Chandrasekharappa, S., Strawderman, M., Ethier, S.P., Merajver, S.D. Clin. Cancer Res. (1999) [Pubmed]
  6. Alanine screening mutagenesis establishes tyrosine 60 of bovine insulin-like growth factor binding protein-2 as a determinant of insulin-like growth factor binding. Hobba, G.D., Löthgren, A., Holmberg, E., Forbes, B.E., Francis, G.L., Wallace, J.C. J. Biol. Chem. (1998) [Pubmed]
  7. Insulin-like growth factor (IGF)-I and IGF-II binding to an IGF binding protein. An investigation using chemical modification of tyrosine residues as a structural probe for the sites of interaction. Moss, J.A., Francis, G.L., Ross, M., Wallace, J.C., Ballard, F.J. J. Biol. Chem. (1991) [Pubmed]
  8. Nucleotide sequence and expression of a cDNA clone encoding a fetal rat binding protein for insulin-like growth factors. Brown, A.L., Chiariotti, L., Orlowski, C.C., Mehlman, T., Burgess, W.H., Ackerman, E.J., Bruni, C.B., Rechler, M.M. J. Biol. Chem. (1989) [Pubmed]
  9. Vascular endothelial growth factor and transforming growth factor-beta1 regulate the expression of insulin-like growth factor-binding protein-3, -4, and -5 in large vessel endothelial cells. Dahlfors, G., Arnqvist, H.J. Endocrinology (2000) [Pubmed]
  10. Relationships among concentrations of steroids, insulin-like growth factor-I, and insulin-like growth factor binding proteins in ovarian follicular fluid of beef cattle. Echternkamp, S.E., Howard, H.J., Roberts, A.J., Grizzle, J., Wise, T. Biol. Reprod. (1994) [Pubmed]
  11. Insulin-like growth factor-I and binding proteins 1, 2, and 3 in bovine nuclear transfer pregnancies. Ravelich, S.R., Breier, B.H., Reddy, S., Keelan, J.A., Wells, D.N., Peterson, A.J., Lee, R.S. Biol. Reprod. (2004) [Pubmed]
  12. Production and hormonal regulation of insulin-like growth factor binding proteins in bovine chondrocytes. Olney, R.C., Smith, R.L., Kee, Y., Wilson, D.M. Endocrinology (1993) [Pubmed]
  13. Insulin-like growth factor (IGF) system in the bovine mammary gland and milk. Baumrucker, C.R., Erondu, N.E. Journal of mammary gland biology and neoplasia. (2000) [Pubmed]
  14. Insulin-like growth factor binding protein production in bovine retinal endothelial cells. Giannini, S., Cresci, B., Manuelli, C., Fujita-Yamaguchi, Y., Romagnani, P., Mohan, S., Rotella, C.M. Metab. Clin. Exp. (1997) [Pubmed]
  15. Insulin-like growth factor binding protein (IGFBP)4 accounts for the connective tissue distribution of endothelial cell IGFBPs perfused through the isolated heart. Boes, M., Booth, B.A., Sandra, A., Dake, B.L., Bergold, A., Bar, R.S. Endocrinology (1992) [Pubmed]
  16. Transcapillary permeability and subendothelial distribution of endothelial and amniotic fluid insulin-like growth factor binding proteins in the rat heart. Bar, R.S., Clemmons, D.R., Boes, M., Busby, W.H., Booth, B.A., Dake, B.L., Sandra, A. Endocrinology (1990) [Pubmed]
  17. Characterization of insulin-like growth factor-binding proteins in the uterus and conceptus during early conceptus elongation in cattle. Keller, M.L., Roberts, A.J., Seidel, G.E. Biol. Reprod. (1998) [Pubmed]
  18. Mechanical regulation of IGF-I and IGF-binding protein gene transcription in bladder smooth muscle cells. Chaqour, B., Han, J.S., Tamura, I., Macarak, E. J. Cell. Biochem. (2002) [Pubmed]
  19. Large variation in steroid concentrations and insulin-like growth factor binding proteins exists among individual small antral follicles collected from within cows at random stages of the estrous cycle. Roberts, A.J., Al-Hassan, M.J., Fricke, P.M., Echternkamp, S.E. J. Anim. Sci. (2006) [Pubmed]
  20. Regulation of IGF binding protein synthesis by a bovine mammary epithelial cell line. Cohick, W.S., Turner, J.D. J. Endocrinol. (1998) [Pubmed]
  21. The expression of the IGF family and GH receptor in the bovine mammary gland. Plath-Gabler, A., Gabler, C., Sinowatz, F., Berisha, B., Schams, D. J. Endocrinol. (2001) [Pubmed]
  22. Insulin-like growth factor I (IGF-I) and long R(3)IGF-I differently affect development and messenger ribonucleic acid abundance for IGF-binding proteins and type I IGF receptors in in vitro produced bovine embryos. Prelle, K., Stojkovic, M., Boxhammer, K., Motlik, J., Ewald, D., Arnold, G.J., Wolf, E. Endocrinology (2001) [Pubmed]
  23. Pregnancy-associated plasma protein-A and insulin-like growth factor binding protein mRNAs in granulosa cells of dominant and subordinate follicles of preovulatory cattle. Santiago, C.A., Voge, J.L., Aad, P.Y., Allen, D.T., Stein, D.R., Malayer, J.R., Spicer, L.J. Domest. Anim. Endocrinol. (2005) [Pubmed]
  24. Periparturient endocrine and metabolic changes in healthy cows and in cows affected by mastitis. Nikolić, J.A., Kulcsár, M., Kátai, L., Nedić, O., Jánosi, S., Huszenicza, G. Journal of veterinary medicine. A, Physiology, pathology, clinical medicine. (2003) [Pubmed]
  25. Delayed colostrum feeding affects IGF-I and insulin plasma concentrations in neonatal calves. Hammon, H.M., Zanker, I.A., Blum, J.W. J. Dairy Sci. (2000) [Pubmed]
  26. Effect of insulin-like growth factors (IGF), FSH, and leptin on IGF-binding-protein mRNA expression in bovine granulosa and theca cells: quantitative detection by real-time PCR. Voge, J.L., Aad, P.Y., Santiago, C.A., Goad, D.W., Malayer, J.R., Allen, D., Spicer, L.J. Peptides (2004) [Pubmed]
  27. Rapid clearance of insulin-like growth factor (IGF)-binding protein species from blood and an associated fall in circulating IGF-I following partial hepatectomy in the rat. Phillips, I.D., Arany, E., Strain, A.J., Han, V.K., Hill, D.J. J. Endocrinol. (1993) [Pubmed]
  28. Insulin-like growth factor system in bovine first-wave dominant and subordinate follicles. de la Sota, R.L., Simmen, F.A., Diaz, T., Thatcher, W.W. Biol. Reprod. (1996) [Pubmed]
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