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Imaizumi, T. et al.

Imaizumi, Yagihashi, Hatakeyama, Yamashita, Ishikawa, Taima, Yoshida, Inoue, Fujita, Yagihashi, Satoh,

Expression of retinoic acid-inducible gene-I in vascular smooth muscle cells stimulated with interferon-gamma.

Vascular smooth muscle cells (SMC) play an important role in atherogenesis and vasospasm. Interferon-gamma (IFN-gamma) is a potent cytokine that regulates immune and inflammatory responses by inducing multiple genes in many types of cells including SMC. Retinoic acid-inducible gene-I (RIG-I) is a putative RNA helicase, but its physiological function is not known. RIG-I is induced in leukemic cells by retinoic acid or in endothelial cells by lipopolysaccharide. We have studied the expression of RIG-I in cultured SMC from human umbilical artery. IFN-gamma stimulated SMC to express RIG-I mRNA and protein in concentration- and time-dependent manners. Immunohistochemical analysis revealed the expression of RIG-I in SMC in vivo. We conclude that RIG-I may play some pathophysiological role in immune and inflammatory reactions in SMC.[1]

References

Expression of retinoic acid-inducible gene-I in vascular smooth muscle cells stimulated with interferon-gamma. Imaizumi, T., Yagihashi, N., Hatakeyama, M., Yamashita, K., Ishikawa, A., Taima, K., Yoshida, H., Inoue, I., Fujita, T., Yagihashi, S., Satoh, K. Life Sci. (2004) [Pubmed]

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