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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Hydroxyurea-associated squamous dysplasia.

We report 2 cases of squamous dysplasia associated with long-term hydroxyurea therapy. The association between hydroxyurea and multiple aggressive squamous cell carcinomas, Bowen's disease, and multiple actinic keratoses in sun-exposed areas after a variable latency period has been increasingly reported. On reviewing the literature, 17 cases were identified and are reviewed, with emphasis on possible pathogenetic mechanisms of carcinogenicity. Squamous dysplasia, a precursor state to a more aggressive condition of multiple squamous cell carcinomas in photoexposed areas, should be added to the well-known cutaneous toxicities of hydroxyurea therapy.[1]


  1. Hydroxyurea-associated squamous dysplasia. Sanchez-Palacios, C., Guitart, J. J. Am. Acad. Dermatol. (2004) [Pubmed]
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