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MeSH Review

Latency Period (Psychology)

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Disease relevance of Latency Period (Psychology)


Psychiatry related information on Latency Period (Psychology)


High impact information on Latency Period (Psychology)

  • The latency period of tumor development correlated inversely with the level of IL-2 secreted [7].
  • N-Methyl-N-nitrosourea (MNU) given iv to rats 50-55 days old induced mammary tumors in 70% of F344/N and 91% W/ICRF inbred females with mean latency periods of 149 and 93 days, respectively [8].
  • In mice, gemfibrozil did not significantly increase the frequency or the mean latency period of tumors [9].
  • Pharmacologic doses of 200 microgram AFP ip three times per week had no effect on either latency period or tumor incidence in mice given injections of MCA and DMBA when compared to albumin-treated and transferrin-treated controls [10].
  • Similar treatment with MS also increased the latency period, though the delay was not as striking as that observed after DEM administration [11].

Chemical compound and disease context of Latency Period (Psychology)


Biological context of Latency Period (Psychology)

  • The relative incidence, latency period, and degree of malignancy of Emu-L-myc tumors compared with Emu-N- or c-myc tumors is consistent with a lower oncogenic potential of the L-myc gene [17].
  • In this report, we showed that AML1 point mutations were found in 6 (46%) of 13 MDS patients among atomic bomb (A-bomb) survivors in Hiroshima. Unlike acute or chronic leukemia patients among A-bomb survivors, MDS patients exposed relatively low-dose radiation and developed the disease after a long latency period [18].
  • Cells (Rat1pEJ6.6) derived from Rat1 cultures after transfection with a plasmid encoding an activated ras protein, showed shorter tumor latency periods (less than 1 versus 7 weeks) [19].
  • Epidermal growth factor does not alter the length of the latency period prior to S phase but appears to stimulate the uptake of [3H]thymidine subsequently [20].
  • One component of MuLV, however, induced leukemia with a shorter latency period and harbored a lengthier long terminal repeat [21].

Anatomical context of Latency Period (Psychology)

  • Concomitantly, resistant C57BL/6 mice, from which both gene products of the Cdkn2a gene have been eliminated, developed pristane-induced plasma cell tumors over a shorter latency period than the traditionally susceptible BALB/cAn strain [22].
  • When melanocytes cultured from MIP-2 transgenic mice null for INK4a/ARF were transplanted into nude mice, melanoma formation occurred in 83% (10/12) of the cases with a latency period of 3 months [23].
  • In contrast to vasopressin, glucagon did not stimulate Mn2+ influx into hepatocytes, but produced both a 3-fold enhancement of the rate of vasopressin-stimulated Mn2+ entry and the abolishment of the latency period [24].
  • These data show that c-myc gene amplification is not an obligatory event associated with A-MuLV transformation, but may be restricted to cell lines derived from NIH3T3. c-myc gene amplification also did not correlate with a reduced latency period for tumour induction in nude mice [25].
  • The differences seen between these and other published results may be related to differences in radiation doses to the thyroid, latency period between time of radiation exposure and development of clinically apparent thyroid cancer, and ethnic background of the study populations [26].

Gene context of Latency Period (Psychology)

  • Female mice coexpressing TGF-alpha and neu developed multifocal mammary tumors which arose after a significantly shorter latency period than either parental strain alone [27].
  • Although the female transgenic mice possessing mutant EGFR developed mammary tumors, the tumors occurred only after a delayed latency period, and were fewer in number [28].
  • In contrast, increased PDGF-A expression in vivo increases tumor incidence and growth rate and decreases the latency period to tumor formation whereas abrogation of PDGF-A expression decreases tumor incidence and increases latency [29].
  • Mammary-directed expression of the wild-type Stat5, constitutively activated Stat5 and carboxyl-terminally truncated dominant negative Stat5 forms resulted in mammary tumors with incidence rates of up to 22% and latency periods of 8-12 months [30].
  • Heterozygous disruption of Runx1 in BXH2 mice resulted in a shortening of the latency period of leukaemia [31].

Analytical, diagnostic and therapeutic context of Latency Period (Psychology)


  1. Immunosuppression in mice after inoculation with 334C, a murine lymphatic leukemia-inducing virus. Schenk, P.J., Buffett, R.F. J. Natl. Cancer Inst. (1977) [Pubmed]
  2. Retroviral insertional mutagenesis: tagging cancer pathways. Mikkers, H., Berns, A. Adv. Cancer Res. (2003) [Pubmed]
  3. Expression of a Pim-1 transgene accelerates lymphoproliferation and inhibits apoptosis in lpr/lpr mice. Möröy, T., Grzeschiczek, A., Petzold, S., Hartmann, K.U. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  4. Roles of bacteriophage T7 gene 4 proteins in providing primase and helicase functions in vivo. Mendelman, L.V., Notarnicola, S.M., Richardson, C.C. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  5. Chromatin structure is required to block transcription of the methylated herpes simplex virus thymidine kinase gene. Buschhausen, G., Wittig, B., Graessmann, M., Graessmann, A. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  6. Plasma cortisol secretion and REM period latency in adult endogenous depression. Asnis, G.M., Halbreich, U., Sachar, E.J., Nathan, R.S., Ostrow, L.C., Novacenko, H., Davis, M., Endicott, J., Puig-Antich, J. The American journal of psychiatry. (1983) [Pubmed]
  7. Autocrine growth and tumorigenicity of interleukin 2-dependent helper T cells transfected with IL-2 gene. Karasuyama, H., Tohyama, N., Tada, T. J. Exp. Med. (1989) [Pubmed]
  8. N-methyl-N-nitrosourea-induced rat mammary tumors. Hormone responsiveness but lack of spontaneous metastasis. Williams, J.C., Gusterson, B., Humphreys, J., Monaghan, P., Coombes, R.C., Rudland, P., Neville, A.M. J. Natl. Cancer Inst. (1981) [Pubmed]
  9. Carcinogen bioassay and mutagenicity studies with the hypolipidemic agent gemfibrozil. Fitzgerald, J.E., Sanyer, J.L., Schardein, J.L., Lake, R.S., McGuire, E.J., de la Iglesia, F.A. J. Natl. Cancer Inst. (1981) [Pubmed]
  10. Accelerated plasmacytoma formation in mice treated with alpha-fetoprotein. Gershwin, M.E., Castles, J.J., Makishima, R. J. Natl. Cancer Inst. (1980) [Pubmed]
  11. Effects of diethyl maleate on aryl hydrocarbon hydroxylase and on 3-methyl-cholanthrene-induced skin tumorigenesis in rats and mice. Chuang, A.H., Mukhtar, H., Bresnick, E. J. Natl. Cancer Inst. (1978) [Pubmed]
  12. Protection by 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) against mammary tumors and leukemia during prolonged feeding of 7,12-dimethylbenz(a)anthracene to female rats. Silinskas, K.C., Okey, A.B. J. Natl. Cancer Inst. (1975) [Pubmed]
  13. Role of nitric oxide in esophageal peristalsis in the opossum. Yamato, S., Spechler, S.J., Goyal, R.K. Gastroenterology (1992) [Pubmed]
  14. A mechanism for slow release of biomagnified cyanobacterial neurotoxins and neurodegenerative disease in Guam. Murch, S.J., Cox, P.A., Banack, S.A. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  15. Correlation of natural killer activity with tumorigenesis of a preneoplastic mouse mammary lesion. Wei, W.Z., Fulton, A., Winkelhake, J., Heppner, G. Cancer Res. (1989) [Pubmed]
  16. Efficacious chemoprevention of primary prostate cancer by flutamide in an autochthonous transgenic model. Raghow, S., Kuliyev, E., Steakley, M., Greenberg, N., Steiner, M.S. Cancer Res. (2000) [Pubmed]
  17. IgH enhancer deregulated expression of L-myc: abnormal T lymphocyte development and T cell lymphomagenesis. Möröy, T., Fisher, P., Guidos, C., Ma, A., Zimmerman, K., Tesfaye, A., DePinho, R., Weissman, I., Alt, F.W. EMBO J. (1990) [Pubmed]
  18. Implications of somatic mutations in the AML1 gene in radiation-associated and therapy-related myelodysplastic syndrome/acute myeloid leukemia. Harada, H., Harada, Y., Tanaka, H., Kimura, A., Inaba, T. Blood (2003) [Pubmed]
  19. Invasiveness and metastatic capability of rat fibroblast-like cells before and after transfection with immortalizing and transforming genes. Van Roy, F.M., Messiaen, L., Liebaut, G., Gao, J., Dragonetti, C.H., Fiers, W.C., Mareel, M.M. Cancer Res. (1986) [Pubmed]
  20. Regulation of growth of cultured hepatic epithelial cells by transferrin. Tsao, M.S., Sanders, G.H., Grisham, J.W. Exp. Cell Res. (1987) [Pubmed]
  21. Graffi murine leukemia virus: molecular cloning and characterization of the myeloid leukemia-inducing agent. Ru, M., Shustik, C., Rassart, E. J. Virol. (1993) [Pubmed]
  22. Efficiency alleles of the Pctr1 modifier locus for plasmacytoma susceptibility. Zhang, S.L., DuBois, W., Ramsay, E.S., Bliskovski, V., Morse, H.C., Taddesse-Heath, L., Vass, W.C., DePinho, R.A., Mock, B.A. Mol. Cell. Biol. (2001) [Pubmed]
  23. Induction of melanoma in murine macrophage inflammatory protein 2 transgenic mice heterozygous for inhibitor of kinase/alternate reading frame. Yang, J., Luan, J., Yu, Y., Li, C., DePinho, R.A., Chin, L., Richmond, A. Cancer Res. (2001) [Pubmed]
  24. Receptor-operated calcium influx in rat hepatocytes. Identification and characterization using manganese. Kass, G.E., Llopis, J., Chow, S.C., Duddy, S.K., Orrenius, S. J. Biol. Chem. (1990) [Pubmed]
  25. Analysis of A-MuLV transformed fibroblast lines for amplification of the c-myc, p53 and c-fos nuclear proto-oncogenes. Colledge, W.H., Gebhardt, A., Edge, M.D., Bell, J.C. Oncogene (1989) [Pubmed]
  26. Ret/PTC activation in benign and malignant thyroid tumors arising in a population exposed to low-dose external-beam irradiation in childhood. Sadetzki, S., Calderon-Margalit, R., Modan, B., Srivastava, S., Tuttle, R.M. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  27. Synergistic interaction of the Neu proto-oncogene product and transforming growth factor alpha in the mammary epithelium of transgenic mice. Muller, W.J., Arteaga, C.L., Muthuswamy, S.K., Siegel, P.M., Webster, M.A., Cardiff, R.D., Meise, K.S., Li, F., Halter, S.A., Coffey, R.J. Mol. Cell. Biol. (1996) [Pubmed]
  28. Epidermal growth factor receptor-dependent activation of Gab1 is involved in ErbB-2-mediated mammary tumor progression. Gillgrass, A., Cardiff, R.D., Sharan, N., Kannan, S., Muller, W.J. Oncogene (2003) [Pubmed]
  29. Paradoxical effects of platelet-derived growth factor-A overexpression in malignant mesothelioma. Antiproliferative effects in vitro and tumorigenic stimulation in vivo. Metheny-Barlow, L.J., Flynn, B., van Gijssel, H.E., Marrogi, A., Gerwin, B.I. Am. J. Respir. Cell Mol. Biol. (2001) [Pubmed]
  30. Deregulation of Stat5 expression and activation causes mammary tumors in transgenic mice. Iavnilovitch, E., Cardiff, R.D., Groner, B., Barash, I. Int. J. Cancer (2004) [Pubmed]
  31. Haploinsufficiency of Runx1/AML1 promotes myeloid features and leukaemogenesis in BXH2 mice. Yamashita, N., Osato, M., Huang, L., Yanagida, M., Kogan, S.C., Iwasaki, M., Nakamura, T., Shigesada, K., Asou, N., Ito, Y. Br. J. Haematol. (2005) [Pubmed]
  32. Idiopathic paraproteinemia. II. Transplantation of the paraprotein-producing clone from old to young C57BL/KaLwRij mice. Radl, J., De Glopper, E.D., Schuit, H.R., Zurcher, C. J. Immunol. (1979) [Pubmed]
  33. The type B leukemogenic virus truncated superantigen is dispensable for T-cell lymphomagenesis. Mustafa, F., Bhadra, S., Johnston, D., Lozano, M., Dudley, J.P. J. Virol. (2003) [Pubmed]
  34. Auditory laterality in depression: relation to circadian patterns and EEG sleep. Berger-Gross, P., Bruder, G.E., Quitkin, F., Goetz, R. Biol. Psychiatry (1985) [Pubmed]
  35. Gamma knife radiosurgery for cerebral arteriovenous malformations in children/adolescents and adults. Part I: Differences in epidemiologic, morphologic, and clinical characteristics, permanent complications, and bleeding in the latency period. Nicolato, A., Lupidi, F., Sandri, M.F., Foroni, R., Zampieri, P., Mazza, C., Maluta, S., Beltramello, A., Gerosa, M. Int. J. Radiat. Oncol. Biol. Phys. (2006) [Pubmed]
  36. Calcium-dependent effects of melatonin inhibition of glutamatergic response in rat striatum. Escames, G., Macías, M., León, J., García, J., Khaldy, H., Martín, M., Vives, F., Acuña-Castroviejo, D. J. Neuroendocrinol. (2001) [Pubmed]
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