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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Eight novel MICB alleles, including a null allele, identified in gastric MALT lymphoma patients.

MICA and MICB, as members of the major histocompatibility complex (MHC) class I-chain-related genes (MIC), encode stress-inducible glycoproteins that act as activating ligands for NKG2D and gammadelta T-cell receptor-bearing cells. We here describe the identification of eight novel MICB variants, including a null allele, which were identified in peripheral blood leukocytes of gastric MALT lymphoma patients. Only two of the novel alleles are characterized by point mutations, whereas the other variants display a recombination of known exonic MICB sequences that may be best explained by intragenic conversions. The novel MICB null allele is characterized by a Cytosin ( C) deletion in a stretch of four Cs beginning from nucleotide 135 of exon 2 that leads to a premature stop codon ( TGA) at codon 66.[1]

References

  1. Eight novel MICB alleles, including a null allele, identified in gastric MALT lymphoma patients. Schroeder, M., Elsner, H.A., Kim, T.D., Blasczyk, R. Tissue Antigens (2004) [Pubmed]
 
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