The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

cytosine     4-amino-3H-pyrimidin-2-one

Synonyms: Cytosin, Zytosin, Cytosinimine, SureCN4059, SureCN8618, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of cytosine


High impact information on cytosine

  • RESULTS: Three mutations in microsatellite instability high (MSI-H) tumors were found in the exon 4 polymorphic poly-cytosin (C)(8) or (C)(9) tract and consisted of a cytosin deletion at position 291 [2].
  • We have shown a possible alternate mechanism for mutagenesis at CpG in which HpaII DNA-(cytosine-5) methyltransferase (M.HpaII) can enzymatically deaminate cytosine (C) to uracil (U) in DNA [Shen, J.-C., Rideout, W.M., III and Jones, P.A., Cell, 71, 1073-1080, (1992)] [3].
  • These data suggest that the A572V mutation of the LH/CGR may have effects on the guanine nucleotide binding protein which activates phospholipase C (Gq) coupling and phospholipase-C activation in addition to its effects on Gs coupling and activation of adenylyl cyclase [4].
  • The adipose conversion in serum-free medium was associated with an increase in cell number, since 0.3 micrograms/ml cytosin arabinoside not only inhibited cell replication, but also prevented the expression of glycero-3-phosphate dehydrogenase activity [5].
  • The novel MICB null allele is characterized by a Cytosin (C) deletion in a stretch of four Cs beginning from nucleotide 135 of exon 2 that leads to a premature stop codon (TGA) at codon 66 [6].

Biological context of cytosine


Associations of cytosine with other chemical compounds


  1. A novel expression system for production of a labile protein in Escherichia coli by infection with cytosin-substituting T4 phage. Noguchi, T., Takahashi, H. Agric. Biol. Chem. (1991) [Pubmed]
  2. Frequent mutations of hepatocyte nuclear factor 1 in colorectal cancer with microsatellite instability. Laurent-Puig, P., Plomteux, O., Bluteau, O., Zinzindohoué, F., Jeannot, E., Dahan, K., Kartheuser, A., Chapusot, C., Cugnenc, P.H., Zucman-Rossi, J. Gastroenterology (2003) [Pubmed]
  3. HhaI and HpaII DNA methyltransferases bind DNA mismatches, methylate uracil and block DNA repair. Yang, A.S., Shen, J.C., Zingg, J.M., Mi, S., Jones, P.A. Nucleic Acids Res. (1995) [Pubmed]
  4. A new constitutively activating point mutation in the luteinizing hormone/choriogonadotropin receptor gene in cases of male-limited precocious puberty. Yano, K., Saji, M., Hidaka, A., Moriya, N., Okuno, A., Kohn, L.D., Cutler, G.B. J. Clin. Endocrinol. Metab. (1995) [Pubmed]
  5. Complete adipose differentiation of 3T3 L1 cells in a chemically defined medium: comparison to serum-containing culture conditions. Hauner, H. Endocrinology (1990) [Pubmed]
  6. Eight novel MICB alleles, including a null allele, identified in gastric MALT lymphoma patients. Schroeder, M., Elsner, H.A., Kim, T.D., Blasczyk, R. Tissue Antigens (2004) [Pubmed]
  7. Tolerance induction across Mls and minor histocompatibility complex by inhibiting activation of T helper type 1 in early period. Sugiura, K., Lee, S., Nagahama, T., Adachi, Y., Ishikawa, J., Ikehara, S. Immunol. Lett. (2001) [Pubmed]
  8. Isolation and analysis of an aciclovir-resistant murine cytomegalovirus mutant. Minematsu, T., Mori, S., Eizuru, Y., Minamishima, Y. Antiviral Res. (2001) [Pubmed]
  9. Maspin--a novel protease inhibitor with tumor-suppressing activity in breast cancer. Maass, N., Hojo, T., Zhang, M., Sager, R., Jonat, W., Nagasaki, K. Acta oncologica (Stockholm, Sweden) (2000) [Pubmed]
  10. Short description of an alternative simplified method for screening recombinant clones within the "AdEasy-System" by Duplex-PCR. Antolovic, D., Koch, M., Bohlmann, I., Kienle, P., Büchler, M., Weitz, J. BMC Biotechnol. (2005) [Pubmed]
  11. Oligosymptomatic cornea verticillata in a heterozygote for Fabry disease: a novel mutation in the alpha-galactosidase gene. Kono, J.O., Podskarbi, T., Shin, Y., Lanzl, I. Cornea (2003) [Pubmed]
  12. Intra- and intermolecular interactions in small bioactive molecules: cooperative features from experimental and theoretical charge-density analysis. Munshi, P., Guru Row, T.N. Acta Crystallogr., B (2006) [Pubmed]
WikiGenes - Universities