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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Lymphoma, Mucosa-Associated Lymphoid Tissue

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Disease relevance of Lymphoma, Mucosa-Associated Lymphoid Tissue


High impact information on Lymphoma, Mucosa-Associated Lymphoid Tissue

  • Inactivating mutations and overexpression of BCL10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32) [6].
  • Here we show that cIAP2 is a ubiquitin ligase (E3) of BCL10 and targets it for degradation, inhibiting antigen receptor-mediated cytokine production. cIAP2-MALT1 lacks E3 activity, and concomitantly, the BCL10 protein is stabilized in MALT lymphomas harboring this fusion [7].
  • A "G insertion" at nucleic acids 481 of the H. pylori fldA gene is not associated with gastric MALT lymphoma [8].
  • CONCLUSIONS: In a subset of gastric MALT lymphomas, homozygous p16 deletions are acquired and may contribute to the transformation from a low-grade to a high-grade malignancy [9].
  • Mucosa-associated lymphoid tissue (MALT) lymphomas are associated with overexpression and constitutive activity of bcl10, a caspase recruitment domain (CARD)-containing protein that activates NF-kappaB [10].

Chemical compound and disease context of Lymphoma, Mucosa-Associated Lymphoid Tissue


Biological context of Lymphoma, Mucosa-Associated Lymphoid Tissue


Anatomical context of Lymphoma, Mucosa-Associated Lymphoid Tissue


Gene context of Lymphoma, Mucosa-Associated Lymphoid Tissue

  • These results correlate well with the nuclear BCL10 expression pattern in both t(1;14) and t(11;18) MALT lymphomas [25].
  • Subclassification of high labeling score (>/=40) for Cdc2/Cdk1 and cyclin B1 and low labeling index (<0.6) for apoptotic cells in H. pylori-associated MALT may help in identifying a population of patients with an increased risk of developing MALT lymphoma [26].
  • This study assessed the value of morphological grading and the expression of the co-stimulatory markers CD40, CD80 and CD86 and their ligands to predict clinical outcome in 23 consecutive low-grade MALT lymphoma patients treated with H. pylori eradication [27].
  • In addition, in 8 of 16 MALT cases, the VH gene rearrangement of MALT lymphoma had the same bands as the CXCR3-positive B lymphocytes in PB [28].
  • Frequency of chromosomal aneuploidies and deletions of the RB and TP53 genes in MALT lymphomas harboring the t(14;18)(q32;q21) [29].

Analytical, diagnostic and therapeutic context of Lymphoma, Mucosa-Associated Lymphoid Tissue

  • Based on the CDR3 sequence amplified from each MALT lymphoma, individual tumor-specific primers were synthesized and used directly in the polymerase chain reaction (PCR) to analyze the sequences of their Ig heavy-chain variable region [30].
  • Defined tumour cell populations from all MALT lymphoma cases were isolated by microdissection from frozen tissue sections and analysed by polymerase chain reaction-single-strand conformational polymorphism (PCR-SSCP) and direct sequencing for somatic mutations in the exon I/intron I region of the gene [31].
  • We have therefore performed a retrospective analysis of t(11;18)(q21;q21) in patients undergoing chemotherapy with the nucleoside analogue cladribine (2CdA) for gastric MALT lymphoma [32].
  • Sequence analysis of VH genes showed that an autoimmune mechanism may be involved in the lymphomagenesis of ocular adnexal MALT lymphoma [33].
  • This study further supports the close interaction between the MALT1 and BCL10 proteins in the pathogenesis of MALT lymphomas and may indicate that BCL10 immunohistochemistry is a simple technique to identify those MALT lymphoma cases with an underlying genetic aberration [34].


  1. Resistance of t(11;18) positive gastric mucosa-associated lymphoid tissue lymphoma to Helicobacter pylori eradication therapy. Liu, H., Ruskon-Fourmestraux, A., Lavergne-Slove, A., Ye, H., Molina, T., Bouhnik, Y., Hamoudi, R.A., Diss, T.C., Dogan, A., Megraud, F., Rambaud, J.C., Du, M.Q., Isaacson, P.G. Lancet (2001) [Pubmed]
  2. Helicobacter heilmannii-associated primary gastric low-grade MALT lymphoma: complete remission after curing the infection. Morgner, A., Lehn, N., Andersen, L.P., Thiede, C., Bennedsen, M., Trebesius, K., Neubauer, B., Neubauer, A., Stolte, M., Bayerdörffer, E. Gastroenterology (2000) [Pubmed]
  3. T(14;18)(q32;q21) involving IGH and MALT1 is a frequent chromosomal aberration in MALT lymphoma. Streubel, B., Lamprecht, A., Dierlamm, J., Cerroni, L., Stolte, M., Ott, G., Raderer, M., Chott, A. Blood (2003) [Pubmed]
  4. Nonfollicular small B-cell lymphomas: a heterogeneous group of patients with distinct clinical features and outcome. Berger, F., Felman, P., Sonet, A., Salles, G., Bastion, Y., Bryon, P.A., Coiffier, B. Blood (1994) [Pubmed]
  5. Long-term follow-up of gastric MALT lymphoma after Helicobacter pylori eradication. Wündisch, T., Thiede, C., Morgner, A., Dempfle, A., Günther, A., Liu, H., Ye, H., Du, M.Q., Kim, T.D., Bayerdörffer, E., Stolte, M., Neubauer, A. J. Clin. Oncol. (2005) [Pubmed]
  6. Inactivating mutations and overexpression of BCL10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32). Zhang, Q., Siebert, R., Yan, M., Hinzmann, B., Cui, X., Xue, L., Rakestraw, K.M., Naeve, C.W., Beckmann, G., Weisenburger, D.D., Sanger, W.G., Nowotny, H., Vesely, M., Callet-Bauchu, E., Salles, G., Dixit, V.M., Rosenthal, A., Schlegelberger, B., Morris, S.W. Nat. Genet. (1999) [Pubmed]
  7. cIAP2 is a ubiquitin protein ligase for BCL10 and is dysregulated in mucosa-associated lymphoid tissue lymphomas. Hu, S., Du, M.Q., Park, S.M., Alcivar, A., Qu, L., Gupta, S., Tang, J., Baens, M., Ye, H., Lee, T.H., Marynen, P., Riley, J.L., Yang, X. J. Clin. Invest. (2006) [Pubmed]
  8. A "G insertion" at nucleic acids 481 of the H. pylori fldA gene is not associated with gastric MALT lymphoma. Liu, H., Peng, H., Hamoudi, R., Mullins, P.D., Ranaldi, R., Bearzi, I., Isaacson, P.G., Du, M.Q. Gastroenterology (2000) [Pubmed]
  9. Deletion analysis of the p16 tumor suppressor gene in gastrointestinal mucosa-associated lymphoid tissue lymphomas. Neumeister, P., Hoefler, G., Beham-Schmid, C., Schmidt, H., Apfelbeck, U., Schaider, H., Linkesch, W., Sill, H. Gastroenterology (1997) [Pubmed]
  10. Caspase recruitment domain (CARD)-dependent cytoplasmic filaments mediate bcl10-induced NF-kappaB activation. Guiet, C., Vito, P. J. Cell Biol. (2000) [Pubmed]
  11. Mucosa-associated lymphoid tissue lymphoma is a disseminated disease in one third of 158 patients analyzed. Thieblemont, C., Berger, F., Dumontet, C., Moullet, I., Bouafia, F., Felman, P., Salles, G., Coiffier, B. Blood (2000) [Pubmed]
  12. Is the polymerase chain reaction or cure of Helicobacter pylori infection of help in the differential diagnosis of early gastric mucosa-associated lymphatic tissue lymphoma? Rudolph, B., Bayerdörffer, E., Ritter, M., Müller, S., Thiede, C., Neubauer, B., Lehn, N., Seifert, E., Otto, P., Hatz, R., Stolte, M., Neubauer, A. J. Clin. Oncol. (1997) [Pubmed]
  13. Phase II study of oxaliplatin for treatment of patients with mucosa-associated lymphoid tissue lymphoma. Raderer, M., Wöhrer, S., Bartsch, R., Prager, G., Drach, J., Hejna, M., Gaiger, A., Turetschek, K., Jaeger, U., Streubel, B., Zielinski, C.C. J. Clin. Oncol. (2005) [Pubmed]
  14. Successful antibiotic treatment of Helicobacter pylori negative gastric mucosa associated lymphoid tissue lymphomas. Raderer, M., Streubel, B., Wöhrer, S., Häfner, M., Chott, A. Gut (2006) [Pubmed]
  15. Duodenal mucosa-associated lymphoid tissue lymphoma: treatment with oral cyclophosphamide. Lepicard, A., Lamarque, D., Lévy, M., Copie-Bergman, C., Chaumette, M.T., Haioun, C., Anglade, M.C., Delchier, J.C. Am. J. Gastroenterol. (2000) [Pubmed]
  16. Bimp1, a MAGUK family member linking protein kinase C activation to Bcl10-mediated NF-kappaB induction. McAllister-Lucas, L.M., Inohara, N., Lucas, P.C., Ruland, J., Benito, A., Li, Q., Chen, S., Chen, F.F., Yamaoka, S., Verma, I.M., Mak, T.W., Núñez, G. J. Biol. Chem. (2001) [Pubmed]
  17. FAS (CD95) mutations are rare in gastric MALT lymphoma but occur more frequently in primary gastric diffuse large B-cell lymphoma. Wohlfart, S., Sebinger, D., Gruber, P., Buch, J., Polgar, D., Krupitza, G., Rosner, M., Hengstschläger, M., Raderer, M., Chott, A., Müllauer, L. Am. J. Pathol. (2004) [Pubmed]
  18. Replication error phenotype and p53 gene mutation in lymphomas of mucosa-associated lymphoid tissue. Peng, H., Chen, G., Du, M., Singh, N., Isaacson, P.G., Pan, L. Am. J. Pathol. (1996) [Pubmed]
  19. A pathway for tumor necrosis factor-alpha-induced Bcl10 nuclear translocation. Bcl10 is up-regulated by NF-kappaB and phosphorylated by Akt1 and then complexes with Bcl3 to enter the nucleus. Yeh, P.Y., Kuo, S.H., Yeh, K.H., Chuang, S.E., Hsu, C.H., Chang, W.C., Lin, H.I., Gao, M., Cheng, A.L. J. Biol. Chem. (2006) [Pubmed]
  20. Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma. Uren, A.G., O'Rourke, K., Aravind, L.A., Pisabarro, M.T., Seshagiri, S., Koonin, E.V., Dixit, V.M. Mol. Cell (2000) [Pubmed]
  21. Salivary gland mucosa-associated lymphoid tissue lymphoma immunoglobulin V(H) genes show frequent use of V1-69 with distinctive CDR3 features. Miklos, J.A., Swerdlow, S.H., Bahler, D.W. Blood (2000) [Pubmed]
  22. Expression of lymphocyte homing receptors and vascular addressins in low-grade gastric B-cell lymphomas of mucosa-associated lymphoid tissue. Dogan, A., Du, M., Koulis, A., Briskin, M.J., Isaacson, P.G. Am. J. Pathol. (1997) [Pubmed]
  23. Blood groups Lewis(b) and ABH expression in gastric mucosa: lack of inter-relation with Helicobacter pylori colonisation and occurrence of gastric MALT lymphoma. Oberhuber, G., Kranz, A., Dejaco, C., Dragosics, B., Mosberger, I., Mayr, W., Radaszkiewicz, T. Gut (1997) [Pubmed]
  24. Antibodies to human gastric epithelial cells and heat shock protein 60 in Helicobacter pylori positive mucosa associated lymphoid tissue lymphoma. Kawahara, Y., Yokota, K., Mizuno, M., Yunoki, N., Uesu, T., Okada, H., Kobayashi, K., Hirai, Y., Oguma, K., Tsuji, T. Gut (1999) [Pubmed]
  25. MALT1 contains nuclear export signals and regulates cytoplasmic localization of BCL10. Nakagawa, M., Hosokawa, Y., Yonezumi, M., Izumiyama, K., Suzuki, R., Tsuzuki, S., Asaka, M., Seto, M. Blood (2005) [Pubmed]
  26. Expression of cdc2 and cyclin B1 in Helicobacter pylori-associated gastric MALT and MALT lymphoma : relationship to cell death, proliferation, and transformation. Banerjee, S.K., Weston, A.P., Zoubine, M.N., Campbell, D.R., Cherian, R. Am. J. Pathol. (2000) [Pubmed]
  27. Histological and immunological parameters to predict treatment outcome of Helicobacter pylori eradication in low-grade gastric MALT lymphoma. de Jong, D., Vyth-Dreese, F., Dellemijn, T., Verra, N., Ruskoné-Fourmestraux, A., Lavergne-Slove, A., Hart, G., Boot, H. J. Pathol. (2001) [Pubmed]
  28. CXCR3-positive B cells found at elevated frequency in the peripheral blood of patients with MALT lymphoma are attracted by MIG and belong to the lymphoma clone. Suefuji, H., Ohshima, K., Karube, K., Kawano, R., Nabeshima, K., Suzumiya, J., Hayabuchi, N., Kikuchi, M. Int. J. Cancer (2005) [Pubmed]
  29. Frequency of chromosomal aneuploidies and deletions of the RB and TP53 genes in MALT lymphomas harboring the t(14;18)(q32;q21). Penas, E.M., Hinz, K., Biller, L., Zivkovic, T., Röser, K., Löning, T., Parwaresch, R., Bokemeyer, C., Dierlamm, J. Cancer Genet. Cytogenet. (2006) [Pubmed]
  30. Somatic hypermutation in low-grade mucosa-associated lymphoid tissue-type B-cell lymphoma. Qin, Y., Greiner, A., Trunk, M.J., Schmausser, B., Ott, M.M., Müller-Hermelink, H.K. Blood (1995) [Pubmed]
  31. c-myc gene abnormalities in mucosa-associated lymphoid tissue (MALT) lymphomas. Peng, H., Diss, T., Isaacson, P.G., Pan, L. J. Pathol. (1997) [Pubmed]
  32. Translocation t(11;18)(q21;q21) is not predictive of response to chemotherapy with 2CdA in patients with gastric MALT lymphoma. Streubel, B., Ye, H., Du, M.Q., Isaacson, P.G., Chott, A., Raderer, M. Oncology (2004) [Pubmed]
  33. Clinical, histopathological, and immunogenetic analysis of ocular adnexal lymphoproliferative disorders: characterization of malt lymphoma and reactive lymphoid hyperplasia. Mannami, T., Yoshino, T., Oshima, K., Takase, S., Kondo, E., Ohara, N., Nakagawa, H., Ohtsuki, H., Harada, M., Akagi, T. Mod. Pathol. (2001) [Pubmed]
  34. MALT1 and BCL10 aberrations in MALT lymphomas and their effect on the expression of BCL10 in the tumour cells. Sagaert, X., Laurent, M., Baens, M., Wlodarska, I., De Wolf-Peeters, C. Mod. Pathol. (2006) [Pubmed]
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