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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Aortic aneurysm repair is associated with a lower inflammatory response compared with surgery for inflammatory bowel disease.

BACKGROUND: Since the plasma cytokine profile reflects the body's inflammatory response to injury, this study was designed to prospectively observe the plasma cytokine levels in response to the degree of different sorts of abdominal surgical trauma. METHODS: Plasma levels of TNF-alpha, type I TNF receptor ( p55), type II TNF receptor ( p75), IL-6, IL-8, IL-10, phospholipase A(2) (PLA(2)), and haptoglobin were measured peri-operatively in patients undergoing bowel resection for inflammatory bowel disease or diverticulitis (IBD) (n = 9), elective repair of abdominal aortic aneurysm (AAA) (n = 9), or laparoscopic cholecystectomy (lap chole) (n = 9). RESULTS: The IBD patients showed a significant (p < 0.05) post-operative elevation in plasma IL-6, p55, p75, and PLA(2) levels, but no significant change in TNF-alpha, IL-8, IL-10 or haptoglobin levels. The AAA patients had a significant post-operative rise in IL-10 levels and a significant decrease in plasma haptoglobin levels, but no significant change of TNF-alpha, IL-6, IL-8, p55, p75, or PLA(2) concentrations. The lap chole patients demonstrated no significant change in any of these parameters. CONCLUSION: These data show that IL-6, IL-10, p55, and p75 are markers to measure the degree of inflammatory stress associated with abdominal operative procedures and demonstrate the relative lack of a cytokine response to laparoscopic cholecystectomy.[1]


  1. Aortic aneurysm repair is associated with a lower inflammatory response compared with surgery for inflammatory bowel disease. Oldenburg, H.S., Siroen, M.P., Boelens, P.G., Sluijter, B.J., Pruitt, J.H., Naseri, A.H., Rauwerda, J.A., Meijer, S., Cuesta, M.A., van Leeuwen, P.A., Moldawer, L.L. European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes. (2004) [Pubmed]
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