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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Deletion of CBFB in a patient with acute myelomonocytic leukemia (AML M4Eo) and inversion 16.

Acute myelomonocytic leukemia with bone marrow eosinophilia (AML M4Eo) is a subtype of AML with distinct morphological features. Inversion (16)(p13.1q22), t(16;16)(p13.1;q22), and del(16)(q22) are nonrandom abnormalities associated with AML M4Eo and a favorable prognosis, compared with the standard risk group for AML. Deletions of the proximal region of the MYH11 gene located at 16p13.1 have been detected in about 20% of patients with inv(16), with an undetermined effect on patient survival. We present the case of a patient with AML M4Eo and inversion 16 with a distal deletion of the CBFB gene at 16q22 detected with fluorescence in situ hybridization. To our knowledge, only one previous report of a similar deletion has appeared in the literature.[1]

References

  1. Deletion of CBFB in a patient with acute myelomonocytic leukemia (AML M4Eo) and inversion 16. Egan, N., O'Reilly, J., Chipper, L., Higgins, M., Herrmann, R., Cannell, P. Cancer Genet. Cytogenet. (2004) [Pubmed]
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