Gene Review:
CBFB - core-binding factor, beta subunit
Homo sapiens
Synonyms:
CBF-beta, Core-binding factor subunit beta, PEA2-beta, PEBP2-beta, PEBP2B, ...
Kitabayashi,
Aikawa,
Nguyen,
Yokoyama,
Ohki,
Warren,
Bravo,
Williams,
Rabbitts,
Da Silva,
Meyer-Monard,
Menot,
Parrado,
Lebel,
Balitrand,
Fenaux,
Micléa,
Rousselot,
Degos,
Dombret,
Chomienne,
Rubnitz,
Pui,
Sakakura,
Hagiwara,
Miyagawa,
Nakashima,
Yoshikawa,
Kin,
Nakase,
Ito,
Yamagishi,
Yazumi,
Chiba,
Ito,
- Failure of embryonic hematopoiesis and lethal hemorrhages in mouse embryos heterozygous for a knocked-in leukemia gene CBFB-MYH11. Castilla, L.H., Wijmenga, C., Wang, Q., Stacy, T., Speck, N.A., Eckhaus, M., Marín-Padilla, M., Collins, F.S., Wynshaw-Boris, A., Liu, P.P. Cell (1996)
- Solution structure of core binding factor beta and map of the CBF alpha binding site. Huang, X., Peng, J.W., Speck, N.A., Bushweller, J.H. Nat. Struct. Biol. (1999)
- Identification of genes that synergize with Cbfb-MYH11 in the pathogenesis of acute myeloid leukemia. Castilla, L.H., Perrat, P., Martinez, N.J., Landrette, S.F., Keys, R., Oikemus, S., Flanegan, J., Heilman, S., Garrett, L., Dutra, A., Anderson, S., Pihan, G.A., Wolff, L., Liu, P.P. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Frequent downregulation of the runt domain transcription factors RUNX1, RUNX3 and their cofactor CBFB in gastric cancer. Sakakura, C., Hagiwara, A., Miyagawa, K., Nakashima, S., Yoshikawa, T., Kin, S., Nakase, Y., Ito, K., Yamagishi, H., Yazumi, S., Chiba, T., Ito, Y. Int. J. Cancer (2005)
- Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia. Liu, P., Tarlé, S.A., Hajra, A., Claxton, D.F., Marlton, P., Freedman, M., Siciliano, M.J., Collins, F.S. Science (1993)
- JunB is required for endothelial cell morphogenesis by regulating core-binding factor {beta}. Licht, A.H., Pein, O.T., Florin, L., Hartenstein, B., Reuter, H., Arnold, B., Lichter, P., Angel, P., Schorpp-Kistner, M. J. Cell Biol. (2006)
- Activation of AML1-mediated transcription by MOZ and inhibition by the MOZ-CBP fusion protein. Kitabayashi, I., Aikawa, Y., Nguyen, L.A., Yokoyama, A., Ohki, M. EMBO J. (2001)
- Structural basis for the heterodimeric interaction between the acute leukaemia-associated transcription factors AML1 and CBFbeta. Warren, A.J., Bravo, J., Williams, R.L., Rabbitts, T.H. EMBO J. (2000)
- Inversion of chromosome 16 and uncommon rearrangements of the CBFB and MYH11 genes in therapy-related acute myeloid leukemia: rare events related to DNA-topoisomerase II inhibitors? Dissing, M., Le Beau, M.M., Pedersen-Bjergaard, J. J. Clin. Oncol. (1998)
- Molecular diagnostics in the treatment of leukemia. Rubnitz, J.E., Pui, C.H. Curr. Opin. Hematol. (1999)
- Altered affinity of CBF beta-SMMHC for Runx1 explains its role in leukemogenesis. Lukasik, S.M., Zhang, L., Corpora, T., Tomanicek, S., Li, Y., Kundu, M., Hartman, K., Liu, P.P., Laue, T.M., Biltonen, R.L., Speck, N.A., Bushweller, J.H. Nat. Struct. Biol. (2002)
- Zebrafish homolog of the leukemia gene CBFB: its expression during embryogenesis and its relationship to scl and gata-1 in hematopoiesis. Blake, T., Adya, N., Kim, C.H., Oates, A.C., Zon, L., Chitnis, A., Weinstein, B.M., Liu, P.P. Blood (2000)
- Identification of the chimeric protein product of the CBFB-MYH11 fusion gene in inv(16) leukemia cells. Liu, P.P., Wijmenga, C., Hajra, A., Blake, T.B., Kelley, C.A., Adelstein, R.S., Bagg, A., Rector, J., Cotelingam, J., Willman, C.L., Collins, F.S. Genes Chromosomes Cancer (1996)
- Structure of the leukemia-associated human CBFB gene. Hajra, A., Collins, F.S. Genomics (1995)
- CBFB-SMMHC is correlated with increased calreticulin expression and suppresses the granulocytic differentiation factor CEBPA in AML with inv(16). Helbling, D., Mueller, B.U., Timchenko, N.A., Schardt, J., Eyer, M., Betts, D.R., Jotterand, M., Meyer-Monard, S., Fey, M.F., Pabst, T. Blood (2005)
- Human CD34+ cells expressing the inv(16) fusion protein exhibit a myelomonocytic phenotype with greatly enhanced proliferative ability. Wunderlich, M., Krejci, O., Wei, J., Mulloy, J.C. Blood (2006)
- The leukemic protein core binding factor beta (CBFbeta)-smooth-muscle myosin heavy chain sequesters CBFalpha2 into cytoskeletal filaments and aggregates. Adya, N., Stacy, T., Speck, N.A., Liu, P.P. Mol. Cell. Biol. (1998)
- The RUNX1 Runt domain at 1.25A resolution: a structural switch and specifically bound chloride ions modulate DNA binding. Bäckström, S., Wolf-Watz, M., Grundström, C., Härd, T., Grundström, T., Sauer, U.H. J. Mol. Biol. (2002)
- A Mutation in the S-switch Region of the Runt Domain Alters the Dynamics of an Allosteric Network Responsible for CBFbeta Regulation. Li, Z., Lukasik, S.M., Liu, Y., Grembecka, J., Bielnicka, I., Bushweller, J.H., Speck, N.A. J. Mol. Biol. (2006)
- Chromosome band 16q22-linked familial AML: exclusion of candidate genes, and possible disease risk modification by NQO1 polymorphisms. Escher, R., Jones, A., Hagos, F., Carmichael, C., Horwitz, M., Olopade, O.I., Scott, H.S. Genes Chromosomes Cancer (2004)
- Structural and functional characterization of Runx1, CBF beta, and CBF beta-SMMHC. Zhang, L., Lukasik, S.M., Speck, N.A., Bushweller, J.H. Blood Cells Mol. Dis. (2003)
- Functional G-CSF pathways in t(8;21) leukemic cells allow for differentiation induction and degradation of AML1-ETO. Da Silva, N., Meyer-Monard, S., Menot, M.L., Parrado, A., Lebel, A., Balitrand, N., Fenaux, P., Micléa, J.M., Rousselot, P., Degos, L., Dombret, H., Chomienne, C. Hematol. J. (2000)
- The protooncogene product, PEBP2beta/CBFbeta, is mainly located in the cytoplasm and has an affinity with cytoskeletal structures. Tanaka, Y., Watanabe, T., Chiba, N., Niki, M., Kuroiwa, Y., Nishihira, T., Satomi, S., Ito, Y., Satake, M. Oncogene (1997)
- In vitro analyses of known and novel RUNX1/AML1 mutations in dominant familial platelet disorder with predisposition to acute myelogenous leukemia: implications for mechanisms of pathogenesis. Michaud, J., Wu, F., Osato, M., Cottles, G.M., Yanagida, M., Asou, N., Shigesada, K., Ito, Y., Benson, K.F., Raskind, W.H., Rossier, C., Antonarakis, S.E., Israels, S., McNicol, A., Weiss, H., Horwitz, M., Scott, H.S. Blood (2002)
- Primary chromosomal rearrangements of leukemia are frequently accompanied by extensive submicroscopic deletions and may lead to altered prognosis. Kolomietz, E., Al-Maghrabi, J., Brennan, S., Karaskova, J., Minkin, S., Lipton, J., Squire, J.A. Blood (2001)
- Variant three-way translocation of inversion 16 in AML-M4Eo confirmed by fluorescence in situ hybridization analysis. Martinez-Climent, J.A., Comes, A.M., Vizcarra, E., Reshmi, S., Benet, I., Marugan, I., Tormo, M., Terol, M.J., Solano, C., Arbona, C., Prosper, F., Barragan, E., Bolufer, P., Rowley, J.D., García-Conde, J. Cancer Genet. Cytogenet. (1999)
- Large fontanelles are a shared feature of haploinsufficiency of RUNX2 and its co-activator CBFB. Goto, T., Aramaki, M., Yoshihashi, H., Nishimura, G., Hasegawa, Y., Takahashi, T., Ishii, T., Fukushima, Y., Kosaki, K. Congenital anomalies. (2004)
- Detection of minimal residual disease in acute myelomonocytic leukemia with abnormal marrow eosinophils by nested polymerase chain reaction with allele specific amplification. Hébert, J., Cayuela, J.M., Daniel, M.T., Berger, R., Sigaux, F. Blood (1994)