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MeSH Review

Leukemia, Myelomonocytic, Acute

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Disease relevance of Leukemia, Myelomonocytic, Acute


High impact information on Leukemia, Myelomonocytic, Acute

  • Complete responses continued for 8, 9, and more than 11 months in three patients; the remaining patient developed acute myelomonocytic leukemia while in complete remission approximately 8 months after the start of IL-2 therapy [6].
  • Human peripheral blood monocytes isolated from normal donors and patients with acute myelomonocytic leukemia (AMML) were separated on a discontinuous density gradient of bovine serum albumin (BSA) into five fractions [7].
  • The French-American-British subtype acute myelomonocytic leukemia with abnormal eosinophils (FAB AML M4Eo) with pericentric inversion of chromosome 16 is cytomorphologically defined by a myelomonoblastic blast population and abnormal eosinophils [8].
  • We have characterized two t(1;11)(q21;q23) translocations that fuse the MLL gene to a novel gene, AF1q on chromosomal band 1q21, in two infants with acute myelomonocytic leukemia (AMMOL) [9].
  • Relapse cell population differs from acute onset clone as shown by absence of the initially activated N-ras oncogene in a patient with acute myelomonocytic leukemia [10].

Chemical compound and disease context of Leukemia, Myelomonocytic, Acute


Biological context of Leukemia, Myelomonocytic, Acute


Anatomical context of Leukemia, Myelomonocytic, Acute


Gene context of Leukemia, Myelomonocytic, Acute


Analytical, diagnostic and therapeutic context of Leukemia, Myelomonocytic, Acute

  • A young female patient of 18 who was diagnosed to have acute myelomonocytic leukemia (AML M4) developed choroidal infiltrate and fundal changes suggestive of acute leukemia deposits while she was in remission and was recovering from chemotherapy induced myelosuppression [31].


  1. All patients with the T(11;16)(q23;p13.3) that involves MLL and CBP have treatment-related hematologic disorders. Rowley, J.D., Reshmi, S., Sobulo, O., Musvee, T., Anastasi, J., Raimondi, S., Schneider, N.R., Barredo, J.C., Cantu, E.S., Schlegelberger, B., Behm, F., Doggett, N.A., Borrow, J., Zeleznik-Le, N. Blood (1997) [Pubmed]
  2. Detection of minimal residual disease in acute myelomonocytic leukemia with abnormal marrow eosinophils by nested polymerase chain reaction with allele specific amplification. Hébert, J., Cayuela, J.M., Daniel, M.T., Berger, R., Sigaux, F. Blood (1994) [Pubmed]
  3. Evidence for differentiation of human leukemic blood cells in diffusion chamber culture. Hoelzer, D., Kurrle, E., Schmücker, H., Harriss, E.B. Blood (1977) [Pubmed]
  4. Chromosome studies in acute leukemias developing in patients with multiple myeloma. Hossfeld, D.K., Holland, J.F., Cooper, R.G., Ellison, R.R. Cancer Res. (1975) [Pubmed]
  5. Circulating membrane vesicles in leukemic blood. Carr, J.M., Dvorak, A.M., Dvorak, H.F. Cancer Res. (1985) [Pubmed]
  6. Interleukin-2 activity in patients with extensive small-cell lung cancer: a phase II trial of Cancer and Leukemia Group B. Clamon, G., Herndon, J., Perry, M.C., Ozer, H., Kreisman, H., Maher, T., Ellerton, J., Green, M.R. J. Natl. Cancer Inst. (1993) [Pubmed]
  7. Altered heterogeneity of monocytes in acute myelomonocytic leukemia. Shannon, B.T., Finkelstein, S., Hester, J.P., Fudenberg, H.H., Merler, E. J. Natl. Cancer Inst. (1983) [Pubmed]
  8. The abnormal eosinophils are part of the leukemic cell population in acute myelomonocytic leukemia with abnormal eosinophils (AML M4Eo) and carry the pericentric inversion 16: a combination of May-Grünwald-Giemsa staining and fluorescence in situ hybridization. Haferlach, T., Winkemann, M., Löffler, H., Schoch, R., Gassmann, W., Fonatsch, C., Schoch, C., Poetsch, M., Weber-Matthiesen, K., Schlegelberger, B. Blood (1996) [Pubmed]
  9. A novel gene, AF1q, fused to MLL in t(1;11) (q21;q23), is specifically expressed in leukemic and immature hematopoietic cells. Tse, W., Zhu, W., Chen, H.S., Cohen, A. Blood (1995) [Pubmed]
  10. Relapse cell population differs from acute onset clone as shown by absence of the initially activated N-ras oncogene in a patient with acute myelomonocytic leukemia. Senn, H.P., Jiricny, J., Fopp, M., Schmid, L., Moroni, C. Blood (1988) [Pubmed]
  11. Multiple myeloma and acute leukemia associated with alkylating agents. Kyle, R.A., Pierre, R.V., Bayrd, E.D. Arch. Intern. Med. (1975) [Pubmed]
  12. Monocytic leukemias. Shaw, M.T. Hum. Pathol. (1980) [Pubmed]
  13. Local and systemic sequelae of mediastinal daunorubicin extravasation in a patient with acute myelomonocytic leukemia. Dührsen, U., Heinrichs, V., Beecken, W.D., Herbst, K., Mross, K., Hossfeld, D.K. Ann. Oncol. (1997) [Pubmed]
  14. Myelomonocytic leukaemia following cyclophosphamide therapy of rheumatoid disease. Love, R.R., Sowa, J.M. Ann. Rheum. Dis. (1975) [Pubmed]
  15. Waldenström's macroglobulinemia complicated with acute myeloid leukemia. Report of a case and review of the literature. Rodríguez, J.N., Fernández-Jurado, A., Martino, M.L., Prados, D. Haematologica (1998) [Pubmed]
  16. Isochromosome 11q in a case of acute myelomonocytic leukemia FAB type M4. Xue, Y.Q., Go, Y., Lu, D.R., Lin, B.J. Leuk. Res. (1990) [Pubmed]
  17. Increased methylation of the c-fms protooncogene in acute myelomonocytic leukemias. Felgner, J., Kreipe, H., Heidorn, K., Jaquet, K., Zschunke, F., Radzun, H.J., Parwaresch, M.R. Pathobiology (1991) [Pubmed]
  18. Cytogenetic evidence of involvement of an early progenitor myeloid cell in 4;11 translocation-associated acute leukemia. Palau, F., Prieto, F., Badia, L., Beneyto, M., Sempere, A., Borrego, D. Cancer Genet. Cytogenet. (1991) [Pubmed]
  19. Conversion of acute undifferentiated leukemia phenotypes: analysis of clonal development. Raghavachar, A., Bartram, C.R., Gaedicke, G., Binder, T., Heil, G., Carbonell, F., Kubanek, B., Kleihauer, E. Leuk. Res. (1986) [Pubmed]
  20. Clinical aspects of acute myeloid leukemias of the FAB types M3 and M4Eo. The AML Cooperative Group. Haferlach, T., Gassmann, W., Löffler, H., Jürgensen, C., Noak, J., Ludwig, W.D., Thiel, E., Haase, D., Fonatsch, C., Becher, R. Ann. Hematol. (1993) [Pubmed]
  21. A unique pattern of central nervous system leukemia in acute myelomonocytic leukemia associated with inv(16)(p13q22). Holmes, R., Keating, M.J., Cork, A., Broach, Y., Trujillo, J., Dalton, W.T., McCredie, K.B., Freireich, E.J. Blood (1985) [Pubmed]
  22. Differential effects of phorbol esters on normal myeloid precursors and leukemic cells: basis for autologous bone marrow reconstitution in acute nonlymphocytic leukemia using phorbol ester-treated bone marrow from patients in remission. Abrahm, J.L., Gerson, S.L., Hoxie, J.A., Tannenbaum, S.H., Cassileth, P.A., Cooper, R.A. Cancer Res. (1986) [Pubmed]
  23. Establishment and characterization of human myelomonocytic (TYS) and histiocytic (TYH) cell lines. Haranaka, K., Satomi, N., Sakurai, A., Haranaka, R., Masuda, E., Ezoe, H., Obara, T., Miwa, S. Int. J. Cancer (1985) [Pubmed]
  24. Retinoic acid regulates IgG Fc receptor expression in human myelomonocytic leukemia cells and normal peripheral monocytes. Nakamura, T., Hemmi, H. Eur. J. Haematol. (1988) [Pubmed]
  25. Cytokinetic changes in the peripheral blood of leukemic patients during cytostatic therapy. V. Effect of VP 16 213 studied with flow cytofluorometry and cytoautoradiography. Riccardi, A., Montecucco, C.M., Mazzini, G., Cresci, R., Traversi, E. Basic and applied histochemistry. (1980) [Pubmed]
  26. A unique AML1 (CBF2A) rearrangement, t(1;21)(p32;q22), observed in a patient with acute myelomonocytic leukemia. Cherry, A.M., Bangs, C.D., Jones, P., Hall, S., Natkunam, Y. Cancer Genet. Cytogenet. (2001) [Pubmed]
  27. Deletion of CBFB in a patient with acute myelomonocytic leukemia (AML M4Eo) and inversion 16. Egan, N., O'Reilly, J., Chipper, L., Higgins, M., Herrmann, R., Cannell, P. Cancer Genet. Cytogenet. (2004) [Pubmed]
  28. Fusion of MLL and MSF in adult de novo acute myelomonocytic leukemia (M4) with t(11;17)(q23;q25). Yamamoto, K., Shibata, F., Yamaguchi, M., Miura, O. Int. J. Hematol. (2002) [Pubmed]
  29. Therapy-related acute myelomonocytic leukemia following successful treatment for acute promyelocytic leukemia. Todisco, E., Testi, A.M., Avvisati, G., Moleti, M.L., Cedrone, M., Cimino, G., Mancini, F., Amadori, S., Mandelli, F. Leukemia (1995) [Pubmed]
  30. T-cell prolymphocytic leukemia with der(11)t(1;11)(q21;q23) and ATM deficiency. Yamaguchi, M., Yamamoto, K., Miki, T., Mizutani, S., Miura, O. Cancer Genet. Cytogenet. (2003) [Pubmed]
  31. Choroidal infiltrates simulating fundal changes of acute leukemia during hematological recovery following high-dose chemotherapy in acute myelomonocytic leukemia in remission. Ghosh, K., Mitra, S., Hiwase, D. Am. J. Hematol. (2000) [Pubmed]
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