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MeSH Review


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Disease relevance of Eosinophilia


High impact information on Eosinophilia


Chemical compound and disease context of Eosinophilia


Biological context of Eosinophilia


Anatomical context of Eosinophilia


Gene context of Eosinophilia

  • The reduced IL-5 production in IL-4-/- mice correlated with reduced helminth-induced eosinophilia, which has been shown to be dependent on IL-5 in vivo [26].
  • Unexpectedly, N. brasiliensis-infected IL-4/13-deficient mice developed elevated IL-5 and eosinophilia, indicating that compensatory mechanisms exist for the expression of IL-5, although serum IgE remained undetectable [27].
  • These findings indicate that IL-9 is not obligatory for the development of eosinophilia and AHR, and imply that other Th2 cytokines can act in a compensatory fashion [28].
  • Human eosinophil peroxidase (EPO) was purified from eosinophil granules derived from the peripheral blood of patients with eosinophilia [29].
  • In contrast, Stat6 signaling only partially mediated antigen-induced eosinophilia with no role in vascular adhesion molecule 1 expression [30].

Analytical, diagnostic and therapeutic context of Eosinophilia


  1. Asthma: mechanisms of disease persistence and progression. Cohn, L., Elias, J.A., Chupp, G.L. Annu. Rev. Immunol. (2004) [Pubmed]
  2. Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma. Robinson, D.S., Hamid, Q., Ying, S., Tsicopoulos, A., Barkans, J., Bentley, A.M., Corrigan, C., Durham, S.R., Kay, A.B. N. Engl. J. Med. (1992) [Pubmed]
  3. Cephalexin-related nephropathy. Verma, S., Kieff, E. JAMA (1975) [Pubmed]
  4. Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice. Gavett, S.H., O'Hearn, D.J., Li, X., Huang, S.K., Finkelman, F.D., Wills-Karp, M. J. Exp. Med. (1995) [Pubmed]
  5. Transfer of granulocyte-macrophage colony-stimulating factor gene to rat lung induces eosinophilia, monocytosis, and fibrotic reactions. Xing, Z., Ohkawara, Y., Jordana, M., Graham, F., Gauldie, J. J. Clin. Invest. (1996) [Pubmed]
  6. Eosinophilia with aberrant T cells and elevated serum levels of interleukin-2 and interleukin-15. Means-Markwell, M., Burgess, T., deKeratry, D., O'Neil, K., Mascola, J., Fleisher, T., Lucey, D. N. Engl. J. Med. (2000) [Pubmed]
  7. Association of the eosinophilia-myalgia syndrome with the ingestion of tryptophan. Hertzman, P.A., Blevins, W.L., Mayer, J., Greenfield, B., Ting, M., Gleich, G.J. N. Engl. J. Med. (1990) [Pubmed]
  8. Scleroderma, fasciitis, and eosinophilia associated with the ingestion of tryptophan. Silver, R.M., Heyes, M.P., Maize, J.C., Quearry, B., Vionnet-Fuasset, M., Sternberg, E.M. N. Engl. J. Med. (1990) [Pubmed]
  9. Eosinophilia associated with Coumadin. Hall, D., Link, K. N. Engl. J. Med. (1981) [Pubmed]
  10. Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma. Kuperman, D.A., Huang, X., Koth, L.L., Chang, G.H., Dolganov, G.M., Zhu, Z., Elias, J.A., Sheppard, D., Erle, D.J. Nat. Med. (2002) [Pubmed]
  11. Pulmonary infiltrates, eosinophilia, and cardiomyopathy following corticosteroid withdrawal in patients with asthma receiving zafirlukast. Wechsler, M.E., Garpestad, E., Flier, S.R., Kocher, O., Weiland, D.A., Polito, A.J., Klinek, M.M., Bigby, T.D., Wong, G.A., Helmers, R.A., Drazen, J.M. JAMA (1998) [Pubmed]
  12. Pulmonary infiltrates and eosinophilia from minocycline. Otero, M., Goodpasture, H.C. JAMA (1983) [Pubmed]
  13. Short ragweed allergen induces eosinophilic lung disease in HLA-DQ transgenic mice. Chapoval, S.P., Nabozny, G.H., Marietta, E.V., Raymond, E.L., Krco, C.J., Andrews, A.G., David, C.S. J. Clin. Invest. (1999) [Pubmed]
  14. Raloxifene (LY139481 HCI) prevents bone loss and reduces serum cholesterol without causing uterine hypertrophy in ovariectomized rats. Black, L.J., Sato, M., Rowley, E.R., Magee, D.E., Bekele, A., Williams, D.C., Cullinan, G.J., Bendele, R., Kauffman, R.F., Bensch, W.R. J. Clin. Invest. (1994) [Pubmed]
  15. 5-oxo-ETE induces pulmonary eosinophilia in an integrin-dependent manner in Brown Norway rats. Stamatiou, P., Hamid, Q., Taha, R., Yu, W., Issekutz, T.B., Rokach, J., Khanapure, S.P., Powell, W.S. J. Clin. Invest. (1998) [Pubmed]
  16. Blockade of CD49d (alpha4 integrin) on intrapulmonary but not circulating leukocytes inhibits airway inflammation and hyperresponsiveness in a mouse model of asthma. Henderson, W.R., Chi, E.Y., Albert, R.K., Chu, S.J., Lamm, W.J., Rochon, Y., Jonas, M., Christie, P.E., Harlan, J.M. J. Clin. Invest. (1997) [Pubmed]
  17. Transduction of a dominant-negative H-Ras into human eosinophils attenuates extracellular signal-regulated kinase activation and interleukin-5-mediated cell viability. Hall, D.J., Cui, J., Bates, M.E., Stout, B.A., Koenderman, L., Coffer, P.J., Bertics, P.J. Blood (2001) [Pubmed]
  18. Peripheral blood eosinophilia in owl monkeys is associated with increased eosinophilopoiesis yet depressed recruitment kinetics to the Chemokine RANTES. Albert, D.L., Brodie, S.J., Sasseville, V.G., Ringler, D.J. Blood (1996) [Pubmed]
  19. Detection of minimal residual disease in acute myelomonocytic leukemia with abnormal marrow eosinophils by nested polymerase chain reaction with allele specific amplification. Hébert, J., Cayuela, J.M., Daniel, M.T., Berger, R., Sigaux, F. Blood (1994) [Pubmed]
  20. A comparison of treatment of canine cyclic hematopoiesis with recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF), G-CSF interleukin-3, and canine G-CSF. Hammond, W.P., Boone, T.C., Donahue, R.E., Souza, L.M., Dale, D.C. Blood (1990) [Pubmed]
  21. Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia. Garcia-Zepeda, E.A., Rothenberg, M.E., Ownbey, R.T., Celestin, J., Leder, P., Luster, A.D. Nat. Med. (1996) [Pubmed]
  22. Tryptophan-associated eosinophilic connective-tissue disease. A new clinical entity? Clauw, D.J., Nashel, D.J., Umhau, A., Katz, P. JAMA (1990) [Pubmed]
  23. Transgenic mice expressing a B cell growth and differentiation factor gene (interleukin 5) develop eosinophilia and autoantibody production. Tominaga, A., Takaki, S., Koyama, N., Katoh, S., Matsumoto, R., Migita, M., Hitoshi, Y., Hosoya, Y., Yamauchi, S., Kanai, Y. J. Exp. Med. (1991) [Pubmed]
  24. Immunity to Trichinella spiralis infection in vitamin A-deficient mice. Carman, J.A., Pond, L., Nashold, F., Wassom, D.L., Hayes, C.E. J. Exp. Med. (1992) [Pubmed]
  25. Regulation of parasite-induced eosinophilia: selectively increased interleukin 5 production in helminth-infected patients. Limaye, A.P., Abrams, J.S., Silver, J.E., Ottesen, E.A., Nutman, T.B. J. Exp. Med. (1990) [Pubmed]
  26. Disruption of the murine IL-4 gene blocks Th2 cytokine responses. Kopf, M., Le Gros, G., Bachmann, M., Lamers, M.C., Bluethmann, H., Köhler, G. Nature (1993) [Pubmed]
  27. Simultaneous disruption of interleukin (IL)-4 and IL-13 defines individual roles in T helper cell type 2-mediated responses. McKenzie, G.J., Fallon, P.G., Emson, C.L., Grencis, R.K., McKenzie, A.N. J. Exp. Med. (1999) [Pubmed]
  28. The absence of interleukin 9 does not affect the development of allergen-induced pulmonary inflammation nor airway hyperreactivity. McMillan, S.J., Bishop, B., Townsend, M.J., McKenzie, A.N., Lloyd, C.M. J. Exp. Med. (2002) [Pubmed]
  29. Molecular cloning of the human eosinophil peroxidase. Evidence for the existence of a peroxidase multigene family. Ten, R.M., Pease, L.R., McKean, D.J., Bell, M.P., Gleich, G.J. J. Exp. Med. (1989) [Pubmed]
  30. Signal transducer and activator of transcription factor 6 (Stat6)-deficient mice are protected from antigen-induced airway hyperresponsiveness and mucus production. Kuperman, D., Schofield, B., Wills-Karp, M., Grusby, M.J. J. Exp. Med. (1998) [Pubmed]
  31. CSF eosinophilia following myelography. Salberg, D.J. JAMA (1980) [Pubmed]
  32. Eosinophils express interleukin 5 and granulocyte macrophage-colony-stimulating factor mRNA at sites of allergic inflammation in asthmatics. Broide, D.H., Paine, M.M., Firestein, G.S. J. Clin. Invest. (1992) [Pubmed]
  33. Relationship between interleukin-5 and eotaxin in regulating blood and tissue eosinophilia in mice. Mould, A.W., Matthaei, K.I., Young, I.G., Foster, P.S. J. Clin. Invest. (1997) [Pubmed]
  34. Association of ethylene-oxide-induced IgE antibodies with symptoms in dialysis patients. Rumpf, K.W., Seubert, S., Seubert, A., Lowitz, H.D., Valentin, R., Rippe, H., Ippen, H., Scheler, F. Lancet (1985) [Pubmed]
  35. Detection of interleukin-5 messenger RNA in Reed-Sternberg cells of Hodgkin's disease with eosinophilia. Samoszuk, M., Nansen, L. Blood (1990) [Pubmed]
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